School of Veterinary Medicine, Department of Veterinary Medicine
安井由美子 ヤスイ ユミコ
E-Mail：
Website：Last Update :2026/09/03Researcher Profile and Settings
Name
YASUI Yumiko
Affiliation (Master)
School of Veterinary Medicine, Department of Veterinary Medicine
Research Activities
Published Papers
Intravenous administration of xenin-25 accelerates cyclic ruminal contractions in healthy conscious sheep., Takenori Onaga; Ami Sakai; Yumiko Yasui, Neuropeptides, 96, 102293 - 102293, 2022 12 Neurotensin and xenin stimulates pancreatic exocrine secretion through the peripheral cholinergic nerves in conscious sheep., Takenori Onaga; Yumiko Yasui; Hideaki Hayashi, General and comparative endocrinology, 326, 114073 - 114073, 2022 09 15 Effects of xenin-25 on insulin and glucagon secretions in healthy conscious sheep, Takenori Onaga; Hideaki Hayashi; Yumiko Yasui, Domestic Animal Endocrinology, Elsevier BV, 77, 106635 - 106635, 2021 10 Messenger RNA expression and localization of xenin in the gastrointestinal tract in sheep, T. Onaga; A. Sakai; M. Kajita; H. Fukuda; Y. Yasui; H. Hayashi, Domestic Animal Endocrinology, Elsevier BV, 74, 106523 - 106523, 2021 01 Reduction of Salivary Cortisol after “Mokuiku” Activities and Exposure to the Fragnance of Sakhalin Spruce (Picea glehnii) Essential Oil., 土居拓務; 土居拓務; 土居拓務; 本田知之; 本田知之; 本田知之; 安井由美子; 安井由美子; 前田尚之; 前田尚之; 酒巻美子; 萩原寛暢; 萩原寛暢; 横田博; 横田博; 横田博, AROMA RESEARCH, 21, (4) , 2020 11 Role of neurotensin in the regulation of gastric motility in healthy conscious sheep, Yakenori Onaga; Tomohiko Shimoda; Taro Ohishi; Yumiko Yasui; Hideaki Hayashi, Small Ruminant Research, Elsevier BV, 172, 31 - 41, 2019 03 Rapid prolactin induction in adult male rats after treatment with diethylstilbestrol., Maeda N; Okumura K; Yamaguchi K; Haeno S; Yasui Y; Kimura N; Ieko T; Miyasho T; Yokota H, J Neuroendocrinol., 2019, (10) , 2019 The effect of exogenous ghrelin on dextran sodium sulfate-induced colitis in lean and obese mice, Yumiko Yasui, Research of One Health, 酪農学園大学, 2016, 1 - 11, 2016 08 Chemopreventive Effects of Astaxanthin on Inflammatory Bowel Disease and Inflammation-Related Colon Carcinogenesis, Masashi Hosokawa; Yumiko Yasui, Carotenoids and Vitamin A in Translational Medicine, 289 - 306, 2013 01 01 Chemopreventive effects of silymarin against 1,2-dimethylhydrazine plus dextran sodium sulfate-induced inflammation-associated carcinogenicity and genotoxicity in the colon of gpt delta rats, Naomi Toyoda-Hokaiwado; Yumiko Yasui; Mina Muramatsu; Kenichi Masumura; Makiko Takamune; Masami Yamada; Toshihiro Ohta; Takuji Tanaka; Takehiko Nohmi, Carcinogenesis, 32, (10) 1512 - 1517, 2011 10 Dietary astaxanthin inhibits colitis and colitis-associated colon carcinogenesis in mice via modulation of the inflammatory cytokines, Yumiko Yasui; Masashi Hosokawa; Nana Mikami; Kazuo Miyashita; Takuji Tanaka, CHEMICO-BIOLOGICAL INTERACTIONS, 193, (1) 79 - 87, 2011 08 Chemoprevention of Azoxymethane/Dextran Sodium Sulfate-Induced Mouse Colon Carcinogenesis by Freeze-Dried Yam Sanyaku and Its Constituent Diosgenin, Noriyuki Miyoshi; Tomoki Nagasawa; Ryota Mabuchi; Yumiko Yasui; Keiji Wakabayashi; Takuji Tanaka; Hiroshi Ohshima, CANCER PREVENTION RESEARCH, 4, (6) 924 - 934, 2011 06 Modulatory effects of capsaicin on n-diethylnitrosamine (DEN)-induced mutagenesis in salmonella typhimurium YG7108 and DEN-induced hepatocarcinogenesis in gpt delta transgenic rats, Naomi Toyoda-Hokaiwado; Yumiko Yasui; Makiko Takamune; Masami Yamada; Mina Muramatsu; Kenichi Masumura; Toshihiro Ohta; Takuji Tanaka; Takehiko Nohmi, Genes and Environment, 33, (4) 160 - 166, 2011 Reply to letter to the editor "Comment on: Dietary flavonoids suppress azoxymethane-induced colonic preneoplastic lesions in male C57BL/Ksj-db/db mice", Shingo Miyamoto; Yumiko Yasui; Hajime Ohigashi; Takuji Tanaka; Akira Murakami, CHEMICO-BIOLOGICAL INTERACTIONS, 185, (1) 79 - 80, 2010 04 Dietary flavonoids suppress azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice, Miyamoto Shingo; Yasui Yumiko; Ohigashi Hajime; Tanaka Takuji; Murakami Akira, Chemico-Biological Interactions, Elsevier, 183, (2) 276 - 283, 2010 01 Preclinical assays for identifying cancer chemopreventive phytochemicals, Takuji Tanaka; Takeru Oyama; Yumiko Yasui; Shigeyuki Sugie, Scholarly Research Exchange, Syrexe, 2009 Zerumbone, a tropical ginger sesquiterpene, inhibits colon and lung carcinogenesis in mice, Mihye Kim; Shingo Miyamoto; Yumiko Yasui; Takeru Oyama; Akira Murakami; Takuji Tanaka, INTERNATIONAL JOURNAL OF CANCER, 124, (2) 264 - 271, 2009 01 A tobacco-specific carcinogen, NNK, enhances AOM/DSS-induced colon carcinogenesis in male A/J mice, Mihye Kim; Shingo Miyamoto; Shigeyuki Sugie; Yumiko Yasui; Rikako Ishigamori-Suzuki; Akira Murakami; Hitoshi Nakagama; Takuji Tanaka, IN VIVO, 22, (5) 557 - 563, 2008 09 Suppressive effects of nobiletin on hyperleptinemia and colitis-related colon carcinogenesis in male ICR mice, Shingo Miyamoto; Yumiko Yasui; Takuji Tanaka; Hajime Ohigashi; Akira Murakami, CARCINOGENESIS, 29, (5) 1057 - 1063, 2008 05 A novel rasH2 mouse carcinogenesis model that is highly susceptible to 4-NQO-induced tongue and esophageal carcinogenesis is useful for preclinical chemoprevention studies, Shingo Miyamoto; Yumiko Yasui; Mihye Kim; Shigeyuki Sugie; Akira Murakami; Rikako Ishigamori-Suzuki; Takuji Tanaka, CARCINOGENESIS, 29, (2) 418 - 426, 2008 02 Tumor-initiating potency of a novel heterocyclic amine, aminophenylnorharman in mouse colonic carcinogenesis model, Hiroyuki Kohno; Yukari Totsuka; Yumiko Yasui; Rikako Suzuki; Shigeyuki Sugie; Keiji Wakabayashi; Takuji Tanaka, INTERNATIONAL JOURNAL OF CANCER, 121, (8) 1659 - 1664, 2007 10 A specific inducible nitric oxide synthase inhibitor, ONO-1714 attenuates inflammation-related large bowel carcinogenesis in male Apc(Min/+) mice, Hiroyuki Kohno; Mami Takahashi; Yumiko Yasui; Rikako Suzuki; Shingo Miyamoto; Yoshihisa Kamanaka; Masao Naka; Takayuki Maruyama; Keiji Wakabayashi; Takuji Tanaka, INTERNATIONAL JOURNAL OF CANCER, 121, (3) 506 - 513, 2007 08 Lack of enhancing effect of lauric acid on the development of aberrant crypt foci in male ICR mice treated with azoxymethane and dextran sodium sulfate, Shingo Miyamoto; Rikako Suzuki; Yumiko Yasui; Hiroyuki Kohno; Shigeyuki Sugie; Akira Murakami; Hajime Ohigashi; Takuji Tanaka, Journal of Toxicologic Pathology, 20, (2) 93 - 100, 2007 07 02 Ursodeoxycholic acid versus sulfasalazine in colitis-related colon carcinogenesis in mice, Hiroyuki Kohno; Rikako Suzuki; Yumiko Yasui; Shingo Miyamoto; Keiji Wakabayashi; Takuji Tanaka, CLINICAL CANCER RESEARCH, 13, (8) 2519 - 2525, 2007 04 A prostaglandin E-2 receptor subtype EP1-selective antagonist, ONO-8711, suppresses 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis, Hiroki Makita; Michihiro Mutoh; Takayuki Maruyama; Kazuhiro Yonemoto; Atsushi Kobayashi; Hideki Fujitsuka; Makoto Toida; Toshiyuki Shibata; Shingo Miyamoto; Yumiko Yasui; Rikako Suzuki; Keiji Wakabayashi; Takuji Tanaka, CARCINOGENESIS, 28, (3) 677 - 684, 2007 03 Dietary β-cryptoxanthin inhibits N-butyl-N-(4-hydroxybutyl) nitrosamine-induced urinary bladder carcinogenesis in male ICR mice, Katsuhito Miyazawa; Shingo Miyamoto; Rikako Suzuki; Yumiko Yasui; Ryosuke Ikeda; Hiroyuki Kohno; Masamichi Yano; Takuji Tanaka; Kazuya Hata; Koji Suzuki, Oncology Reports, Spandidos Publications, 17, (2) 297 - 304, 2007 9trans,11trans conjugated linoleic acid inhibits the development of azoxymethane-induced colonic aberrant crypt foci in rats, Yumiko Yasui; Rikako Suzuki; Hiroyuki Kohno; Shingo Miyamoto; Fumiaki Beppu; Masashi Hosokawa; Kazuo Miyashita; Takuji Tanaka, NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 59, (1) 82 - 91, 2007 Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats, H Kohno; R Suzuki; Y Yasui; M Hosokawa; K Miyashita; T Tanaka, CANCER SCIENCE, 95, (6) 481 - 486, 2004 06 Dietary effects of bitter gourd oil on blood and liver lipids of rats, R Noguchi; Y Yasui; R Suzuki; M Hosokawa; K Fukunaga; K Miyashita, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 396, (2) 207 - 212, 2001 12
Books etc
デュークス獣医生理学, Dukes, Henry Hugh; 鈴木, 浩悦; 澁谷, 泉; 翁長, 武紀; 田谷, 一善, 42-46章, 学窓社, 2020 03 , 9784873627724
Conference Activities & Talks
精油による痒み抑制効果の検討, 安井由美子, 第10回アカエゾマツサミット
Works
共役ﾘﾉｰﾙ酸異性体によるﾗｯﾄ大腸発がん抑制効果とその機構解析
Misc
フコキサンチンの大腸発がん予防 (特集 食品と疾病 : フコキサンチン), 安井 由美子; 田中 卓二, Functional food : 機能性食品の基礎から臨床へ, 6, (4) 239 - 243, 2013 Cancer Chemopreventive Ability of Conjugated Linolenic Acids, Takuji Tanaka; Masashi Hosokawa; Yumiko Yasui; Rikako Ishigamori; Kazuo Miyashita, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 12, (11) 7495 - 7509, 2011 11 , 10.3390/ijms12117495 Chemoprevention of colorectal carcinogenesis by natural anti-inflammatory agents, Yumiko Yasui; Takuji Tanaka, American Journal of Community Psychology, 48, (1-2) 150 - 157, 2011 09 P-105 Chemopreventive effects of silymarin and capsaicin on mutagenesis and carcinogenesis using gpt delta transgenic rat(Poster Presentation), Muramatsu Mina; Toyoda-Hokaiwado Naomi; Yasui Yumiko; Masumura Kenichi; Takamune Makiko; Yamada Masami; Tanaka Takuji; Ohta Toshihiro; Nohmi Takehiko, 日本環境変異原学会大会プログラム・要旨集, (39) 145 - 145, 2010 Dietary Tricin Suppresses Inflammation-Related Colon Carcinogenesis in Male Crj: CD-1 Mice, Takeru Oyama; Yumiko Yasui; Shigeyuki Sugie; Mamoru Koketsu; Kunitomo Watanabe; Takuji Tanaka, CANCER PREVENTION RESEARCH, 2, (12) 1031 - 1038, 2009 12 , 10.1158/1940-6207.CAPR-09-0061 アスタキサンチンのデキストラン硫酸ナトリウム誘発マウス大腸炎に対する予防効果, 細川 雅史; 安井 由美子; 三瓶 雄司; 三上 奈々; 宮下 和夫; 田中 卓二, 日本栄養・食糧学会大会講演要旨集, 63回, 2009 05 Aqueous and ethanolic extract fractions from the Brazilian propolis suppress azoxymethane-induced aberrant crypt foci in rats, Yumiko Yasui; Shingo Miyamoto; Mihye Kim; Hiroyuki Kohno; Shigeyuki Sugie; Takuji Tanaka, ONCOLOGY REPORTS, 20, (3) 493 - 499, 2008 09 , 10.3892/or_00000033 A Novel Prodrug of 4 '-Geranyloxy-Ferulic Acid Suppresses Colitis-Related Colon Carcinogenesis in Mice, Shingo Miyamoto; Francesco Epifano; Massimo Curini; Salvatore Genovese; Mihye Kim; Rikako Ishigamori-Suzuki; Yumiko Yasui; Shigeyuki Sugie; Takuji Tanaka, NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 60, (5) 675 - 684, 2008 09 , 10.1080/01635580802008286 AGFD 62-The suppression effects of conjugated linolenic acids on chemically induced colon carcinogenesis., Yumiko Yasui; Masashi Hosokawa; Kazuo Miyashita; Takuji Tanaka, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 236, 2008 08 A lipophilic statin, pitavastatin, suppresses inflammation-associated mouse colon carcinogenesis, Yumiko Yasui; Rikako Suzuki; Shingo Miyamoto; Tetsuya Tsukamoto; Shigeyuki Sugie; Hiroyuki Kohno; Takuji Tanaka, INTERNATIONAL JOURNAL OF CANCER, 121, (10) 2331 - 2339, 2007 11 , 10.1002/ije.22976 Global gene expression analysis of the mouse colonic mucosa treated with azoxymethane and dextran sodium sulfate, Rikako Suzuki; Shingo Miyamoto; Yumiko Yasui; Shigeyuki Sugie; Takuji Tanaka, BMC CANCER, 7, 2007 05 , 10.1186/1471-2407-7-84 Chemopreventive effects of conjugated linolenic acids (CLN) occurring in plant seed oils, Bhaskar Narayan; Masashi Hosokawa; Yumiko Yasui; Rikako Suzuki; Hiroyuki Kohno; Takuji Tanaka; Kazuo Miyashita, Current Nutrition and Food Science, 3, (4) 309 - 318, 2007 , 10.2174/1573401310703040309 Bitter gourd seed fatty acid rich in 9c,11t,13t-conjugated linolenic acid induces apoptosis and up-regulates the GADD45, p53 and PPARgamma in human colon cancer Caco-2 cells, YASUI Y, Prostaglandins Leukot Essent Fatty Acids, 73, 2005 Dietary seed oil rich in conjugated linolenic acid from bitter melon inhibits azoxymethane-induced rat colon carcinogenesis through elevation of colonic PPAR gamma expression and alteration of lipid composition, H Kohno; Y Yasui; R Suzuki; M Hosokawa; K Miyashita; T Tanaka, INTERNATIONAL JOURNAL OF CANCER, 110, (6) 896 - 901, 2004 07 , 10.1002/ijc.20179
Research Grants & Projects
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Suppressing itching and extinguishing dermatitis with Pinaceae essential oil, 202404, 202703, 安井 由美子 日本学術振興会, 科学研究費助成事業, アカエゾマツの香りが妊娠・出産・成長に与える効果, 20220401, 20250331, 宮庄 拓; 前田 尚之; 安井 由美子 Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Preventive effects of marine carotenoids on chronic inflammation-related diseases through regulation of cell and tissue communication, 20110401, 20140331, HOSOKAWA Masashi; YASUI Yumiko, Fucoxanthin (Fx) suppressed chronic inflammation in white adipose tissue by the inhibition of macrophage and T cell infiltration. Further, Fx down-regulated mRNA expression of chemokines and adipokines, which recruit immune cells and induce insulin resistance. In diabetic/obese mice fed Fx, GLUT4 activation was observed in skeletal muscle through the improvement of hyperglycemia. On the other hand, Fx and astaxanthin (Asx) extracted from H. pluvialis prevent DSS-induced colitis and colon carcinogenesis in mice. In colon of the mice fed Asx, mRNA expression levels of inflammatory cytokines tended to decrease compared to control mice. In addition, Asx down-regulated mRNA expression of inflammatory cytokines in macrophage-like cells and colon cells stimulated by the culture medium of activated macrophages. These results suggest that marine carotenoids prevent chronic inflammation and its-related diseases by the regulation of cell and tissue communication via chemokines and cytokines. Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Analysis of the relation between prostate carcinognenesis targeted stem cells and inflammation, 2009, 2011, SUGIE Shigeyuki; TANAKA Takuji; YASUI Yumiko; OYAMA Takeru, In this study, the relation between prostate carcinogenesis and stem cell or inflammation is analyse in animal experimental carcinogenesis model targeted stem cells associated with prostatitis. Any prostate neoplasma were not found in any castrated rats, although prostate neoplasms was observed only in non-castration groups. From these results, the origin of cancer was assumed to be lost by castration. TP had a suppressive effect in PhIP prostate carcinogenesis. he hypothesis which Prostate cancer originated from stem cell. The lobes with inflammation were different the lobes with PIN. The modifying effect of inflammation for prostate carcinogenesis is not clear, yet. Further consideration will be necessary. Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Involvement of obesity in oral carcinogenesis using animal models, 2008, 2010, TANAKA Takuji; SUGIE Shigeyuki; YASUI Yumiko, We investigated whether obesity influences oral (tongue) carcinogenesis using obese model animals, such as db/db and ob/ob mice. The results indicated that the obese mice were highly susceptible to 4-NQO-induced tongue and esophageal carcinogenesis when compared to their wild types (WT) of mice. In addition, the susceptibility was high in db/db mice in comparison with ob/ob mice. The immunohistochemical expression of pro-inflammatory cytokines (IL-1α, IL-1β, interleukin-4, interleukin-6, interleukin-8, and TNF-α) in the tongue squamous cell carcinomas which developed in the db/db mice were significantly greater than that developed in the WT mice (p<0.05-p<0.01). However, there were no significant differences in the expressions of NF-κB, Stat3, and Nrf2 between the obese and WT mice. Our results may suggest that overexpression of these pro-inflammatory cytokines plays an important role in highly susceptible to 4-NQO-induced tongue and esophageal carcinogenesis in obese mice. Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Preventive effects of marine carotenoids on life-style-related diseases based on anti-inflammatory effects as molecular targets, 2008, 2010, HOSOKAWA Masashi; YASUI Yumiko, Astaxanthin exhibited inhibitory effects on dextran sodium sulfate-induced colitis and inflammatory-related colon carcinogenesis in mice. In colon of the mice fed astaxanthin, mRNA expression levels of inflammatory cytokines such as TNF-α and IL-1β were suppressed through inhibition of NF-κB activation. After feeding for 20 weeks, colonic mucosal ulcers, dysplastic crypts and colonic adenocarcinoma were inhibited by 200 ppm astaxanthin-containing diet. In addition, astaxanthin, pectenolone, alloxanthin and diatoxanthin isolated from marine organisms attenuated excessive mRNA expression of inflammatory cytokines and COX-2 and iNOS in macrophages activated by LPS. On the other hand, dietary 0.2% fucoxanthin markedly suppressed mRNA expression of inflammatory cytokines such as TNF-α and IL-6 to induce insulin resistance and inhibited macrophage infiltration in white adipose tissue through suppression of MCP-1 mRNA expression after 4 weeks feeding. Further, fucoxanthinol, which is one of fucoxanthin metabolites, also regulated cross talk of adipocytes and macrophages via palmitic acid and TNF-α. These results suggest that anti-inflammatory effects are molecular mechanism for anti-obesity and anti-diabetic effects of fucoxanthin. 日本学術振興会, 科学研究費助成事業, 炎症性大腸発がんモデルマウスを用いた共役リノレン酸の発がん阻止効果に関する研究, 2006, 2007, 安井 由美子, 平成19年度は平成18年度に続き、20週目の剖検時における病理組織学的解析と、採取した大腸粘膜を用いて、発がんに関与する遺伝子の発現をリアルタイムPCRにて解析を行った。剖検時、いずれの実験群にも体重および肝重量に有意な差は見られなかった。一方、大腸の長さに関してはAOM+1.5% DSS+0.1% PGO群において、その他の群よりも、大腸が有意に短かった。大腸粘膜潰瘍と異型陰窩の発生に関して、AOM+1.5% DSS群と比較して、PGO処理によりいずれの濃度においても有意な(P<0.001)抑制が観察された。大腸腺腫の発生に関してはAOM+1.5% DSS群(0.9±1.10)で50%の発生が見られ、1% PGO処理(0.3±0.71)により抑制傾向が見られたものの有意な差は得られなかった。一方、腺がんの発生に関しては、AOM+1.5% DSS群(2.9±1.29)で90%の発生が見られ、いずれの濃度においても有意抑制効果が見られた(0.01% PGO:0.9±0.78,P<0.01,0.1% PGO:1.2±1.14,P<0.05,1%PGO:0.9±1.27,P<0.01)。さらに、大腸粘膜における発がん関連遺伝子(PPARγ、COX-2)の発現をリアルタイムPCRで解析した。その結果、20週時においてPGO処理によるPPARγの発現増加、COX-2の発現抑制の傾向が得られた。以上の結果から、CLNを高濃度含有するPGOは、炎症を背景とする大腸がんの発生を抑制することが明らかとなった。また、腺腫の発生に有意な差は見られず、腺がんの発生において顕著な抑制が見られたことから、特に腺腫から腺がんに進行するプログレッションの段階にPGOが作用することが示唆された。 天然物による発がん阻止とその機構解析, 2006
教員総覧
E-Mail：
Website：
Last Update :2026/09/03
Researcher Profile and Settings
Name
| YASUI Yumiko |
Affiliation (Master)
| School of Veterinary Medicine, Department of Veterinary Medicine |
Research Activities
Published Papers
| Intravenous administration of xenin-25 accelerates cyclic ruminal contractions in healthy conscious sheep., Takenori Onaga; Ami Sakai; Yumiko Yasui, Neuropeptides, 96, 102293 - 102293, 2022 12 |
| Neurotensin and xenin stimulates pancreatic exocrine secretion through the peripheral cholinergic nerves in conscious sheep., Takenori Onaga; Yumiko Yasui; Hideaki Hayashi, General and comparative endocrinology, 326, 114073 - 114073, 2022 09 15 |
| Effects of xenin-25 on insulin and glucagon secretions in healthy conscious sheep, Takenori Onaga; Hideaki Hayashi; Yumiko Yasui, Domestic Animal Endocrinology, Elsevier BV, 77, 106635 - 106635, 2021 10 |
| Messenger RNA expression and localization of xenin in the gastrointestinal tract in sheep, T. Onaga; A. Sakai; M. Kajita; H. Fukuda; Y. Yasui; H. Hayashi, Domestic Animal Endocrinology, Elsevier BV, 74, 106523 - 106523, 2021 01 |
| Reduction of Salivary Cortisol after “Mokuiku” Activities and Exposure to the Fragnance of Sakhalin Spruce (Picea glehnii) Essential Oil., 土居拓務; 土居拓務; 土居拓務; 本田知之; 本田知之; 本田知之; 安井由美子; 安井由美子; 前田尚之; 前田尚之; 酒巻美子; 萩原寛暢; 萩原寛暢; 横田博; 横田博; 横田博, AROMA RESEARCH, 21, (4) , 2020 11 |
| Role of neurotensin in the regulation of gastric motility in healthy conscious sheep, Yakenori Onaga; Tomohiko Shimoda; Taro Ohishi; Yumiko Yasui; Hideaki Hayashi, Small Ruminant Research, Elsevier BV, 172, 31 - 41, 2019 03 |
| Rapid prolactin induction in adult male rats after treatment with diethylstilbestrol., Maeda N; Okumura K; Yamaguchi K; Haeno S; Yasui Y; Kimura N; Ieko T; Miyasho T; Yokota H, J Neuroendocrinol., 2019, (10) , 2019 |
| The effect of exogenous ghrelin on dextran sodium sulfate-induced colitis in lean and obese mice, Yumiko Yasui, Research of One Health, 酪農学園大学, 2016, 1 - 11, 2016 08 |
| Chemopreventive Effects of Astaxanthin on Inflammatory Bowel Disease and Inflammation-Related Colon Carcinogenesis, Masashi Hosokawa; Yumiko Yasui, Carotenoids and Vitamin A in Translational Medicine, 289 - 306, 2013 01 01 |
| Chemopreventive effects of silymarin against 1,2-dimethylhydrazine plus dextran sodium sulfate-induced inflammation-associated carcinogenicity and genotoxicity in the colon of gpt delta rats, Naomi Toyoda-Hokaiwado; Yumiko Yasui; Mina Muramatsu; Kenichi Masumura; Makiko Takamune; Masami Yamada; Toshihiro Ohta; Takuji Tanaka; Takehiko Nohmi, Carcinogenesis, 32, (10) 1512 - 1517, 2011 10 |
| Dietary astaxanthin inhibits colitis and colitis-associated colon carcinogenesis in mice via modulation of the inflammatory cytokines, Yumiko Yasui; Masashi Hosokawa; Nana Mikami; Kazuo Miyashita; Takuji Tanaka, CHEMICO-BIOLOGICAL INTERACTIONS, 193, (1) 79 - 87, 2011 08 |
| Chemoprevention of Azoxymethane/Dextran Sodium Sulfate-Induced Mouse Colon Carcinogenesis by Freeze-Dried Yam Sanyaku and Its Constituent Diosgenin, Noriyuki Miyoshi; Tomoki Nagasawa; Ryota Mabuchi; Yumiko Yasui; Keiji Wakabayashi; Takuji Tanaka; Hiroshi Ohshima, CANCER PREVENTION RESEARCH, 4, (6) 924 - 934, 2011 06 |
| Modulatory effects of capsaicin on n-diethylnitrosamine (DEN)-induced mutagenesis in salmonella typhimurium YG7108 and DEN-induced hepatocarcinogenesis in gpt delta transgenic rats, Naomi Toyoda-Hokaiwado; Yumiko Yasui; Makiko Takamune; Masami Yamada; Mina Muramatsu; Kenichi Masumura; Toshihiro Ohta; Takuji Tanaka; Takehiko Nohmi, Genes and Environment, 33, (4) 160 - 166, 2011 |
| Reply to letter to the editor "Comment on: Dietary flavonoids suppress azoxymethane-induced colonic preneoplastic lesions in male C57BL/Ksj-db/db mice", Shingo Miyamoto; Yumiko Yasui; Hajime Ohigashi; Takuji Tanaka; Akira Murakami, CHEMICO-BIOLOGICAL INTERACTIONS, 185, (1) 79 - 80, 2010 04 |
| Dietary flavonoids suppress azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice, Miyamoto Shingo; Yasui Yumiko; Ohigashi Hajime; Tanaka Takuji; Murakami Akira, Chemico-Biological Interactions, Elsevier, 183, (2) 276 - 283, 2010 01 |
| Preclinical assays for identifying cancer chemopreventive phytochemicals, Takuji Tanaka; Takeru Oyama; Yumiko Yasui; Shigeyuki Sugie, Scholarly Research Exchange, Syrexe, 2009 |
| Zerumbone, a tropical ginger sesquiterpene, inhibits colon and lung carcinogenesis in mice, Mihye Kim; Shingo Miyamoto; Yumiko Yasui; Takeru Oyama; Akira Murakami; Takuji Tanaka, INTERNATIONAL JOURNAL OF CANCER, 124, (2) 264 - 271, 2009 01 |
| A tobacco-specific carcinogen, NNK, enhances AOM/DSS-induced colon carcinogenesis in male A/J mice, Mihye Kim; Shingo Miyamoto; Shigeyuki Sugie; Yumiko Yasui; Rikako Ishigamori-Suzuki; Akira Murakami; Hitoshi Nakagama; Takuji Tanaka, IN VIVO, 22, (5) 557 - 563, 2008 09 |
| Suppressive effects of nobiletin on hyperleptinemia and colitis-related colon carcinogenesis in male ICR mice, Shingo Miyamoto; Yumiko Yasui; Takuji Tanaka; Hajime Ohigashi; Akira Murakami, CARCINOGENESIS, 29, (5) 1057 - 1063, 2008 05 |
| A novel rasH2 mouse carcinogenesis model that is highly susceptible to 4-NQO-induced tongue and esophageal carcinogenesis is useful for preclinical chemoprevention studies, Shingo Miyamoto; Yumiko Yasui; Mihye Kim; Shigeyuki Sugie; Akira Murakami; Rikako Ishigamori-Suzuki; Takuji Tanaka, CARCINOGENESIS, 29, (2) 418 - 426, 2008 02 |
| Tumor-initiating potency of a novel heterocyclic amine, aminophenylnorharman in mouse colonic carcinogenesis model, Hiroyuki Kohno; Yukari Totsuka; Yumiko Yasui; Rikako Suzuki; Shigeyuki Sugie; Keiji Wakabayashi; Takuji Tanaka, INTERNATIONAL JOURNAL OF CANCER, 121, (8) 1659 - 1664, 2007 10 |
| A specific inducible nitric oxide synthase inhibitor, ONO-1714 attenuates inflammation-related large bowel carcinogenesis in male Apc(Min/+) mice, Hiroyuki Kohno; Mami Takahashi; Yumiko Yasui; Rikako Suzuki; Shingo Miyamoto; Yoshihisa Kamanaka; Masao Naka; Takayuki Maruyama; Keiji Wakabayashi; Takuji Tanaka, INTERNATIONAL JOURNAL OF CANCER, 121, (3) 506 - 513, 2007 08 |
| Lack of enhancing effect of lauric acid on the development of aberrant crypt foci in male ICR mice treated with azoxymethane and dextran sodium sulfate, Shingo Miyamoto; Rikako Suzuki; Yumiko Yasui; Hiroyuki Kohno; Shigeyuki Sugie; Akira Murakami; Hajime Ohigashi; Takuji Tanaka, Journal of Toxicologic Pathology, 20, (2) 93 - 100, 2007 07 02 |
| Ursodeoxycholic acid versus sulfasalazine in colitis-related colon carcinogenesis in mice, Hiroyuki Kohno; Rikako Suzuki; Yumiko Yasui; Shingo Miyamoto; Keiji Wakabayashi; Takuji Tanaka, CLINICAL CANCER RESEARCH, 13, (8) 2519 - 2525, 2007 04 |
| A prostaglandin E-2 receptor subtype EP1-selective antagonist, ONO-8711, suppresses 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis, Hiroki Makita; Michihiro Mutoh; Takayuki Maruyama; Kazuhiro Yonemoto; Atsushi Kobayashi; Hideki Fujitsuka; Makoto Toida; Toshiyuki Shibata; Shingo Miyamoto; Yumiko Yasui; Rikako Suzuki; Keiji Wakabayashi; Takuji Tanaka, CARCINOGENESIS, 28, (3) 677 - 684, 2007 03 |
| Dietary β-cryptoxanthin inhibits N-butyl-N-(4-hydroxybutyl) nitrosamine-induced urinary bladder carcinogenesis in male ICR mice, Katsuhito Miyazawa; Shingo Miyamoto; Rikako Suzuki; Yumiko Yasui; Ryosuke Ikeda; Hiroyuki Kohno; Masamichi Yano; Takuji Tanaka; Kazuya Hata; Koji Suzuki, Oncology Reports, Spandidos Publications, 17, (2) 297 - 304, 2007 |
| 9trans,11trans conjugated linoleic acid inhibits the development of azoxymethane-induced colonic aberrant crypt foci in rats, Yumiko Yasui; Rikako Suzuki; Hiroyuki Kohno; Shingo Miyamoto; Fumiaki Beppu; Masashi Hosokawa; Kazuo Miyashita; Takuji Tanaka, NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 59, (1) 82 - 91, 2007 |
| Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats, H Kohno; R Suzuki; Y Yasui; M Hosokawa; K Miyashita; T Tanaka, CANCER SCIENCE, 95, (6) 481 - 486, 2004 06 |
| Dietary effects of bitter gourd oil on blood and liver lipids of rats, R Noguchi; Y Yasui; R Suzuki; M Hosokawa; K Fukunaga; K Miyashita, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 396, (2) 207 - 212, 2001 12 |
Books etc
| デュークス獣医生理学, Dukes, Henry Hugh; 鈴木, 浩悦; 澁谷, 泉; 翁長, 武紀; 田谷, 一善, 42-46章, 学窓社, 2020 03 , 9784873627724 |
Conference Activities & Talks
| 精油による痒み抑制効果の検討, 安井由美子, 第10回アカエゾマツサミット |
Works
| 共役ﾘﾉｰﾙ酸異性体によるﾗｯﾄ大腸発がん抑制効果とその機構解析 |
Misc
| フコキサンチンの大腸発がん予防 (特集 食品と疾病 : フコキサンチン), 安井 由美子; 田中 卓二, Functional food : 機能性食品の基礎から臨床へ, 6, (4) 239 - 243, 2013 |
| Cancer Chemopreventive Ability of Conjugated Linolenic Acids, Takuji Tanaka; Masashi Hosokawa; Yumiko Yasui; Rikako Ishigamori; Kazuo Miyashita, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 12, (11) 7495 - 7509, 2011 11 , 10.3390/ijms12117495 |
| Chemoprevention of colorectal carcinogenesis by natural anti-inflammatory agents, Yumiko Yasui; Takuji Tanaka, American Journal of Community Psychology, 48, (1-2) 150 - 157, 2011 09 |
| P-105 Chemopreventive effects of silymarin and capsaicin on mutagenesis and carcinogenesis using gpt delta transgenic rat(Poster Presentation), Muramatsu Mina; Toyoda-Hokaiwado Naomi; Yasui Yumiko; Masumura Kenichi; Takamune Makiko; Yamada Masami; Tanaka Takuji; Ohta Toshihiro; Nohmi Takehiko, 日本環境変異原学会大会プログラム・要旨集, (39) 145 - 145, 2010 |
| Dietary Tricin Suppresses Inflammation-Related Colon Carcinogenesis in Male Crj: CD-1 Mice, Takeru Oyama; Yumiko Yasui; Shigeyuki Sugie; Mamoru Koketsu; Kunitomo Watanabe; Takuji Tanaka, CANCER PREVENTION RESEARCH, 2, (12) 1031 - 1038, 2009 12 , 10.1158/1940-6207.CAPR-09-0061 |
| アスタキサンチンのデキストラン硫酸ナトリウム誘発マウス大腸炎に対する予防効果, 細川 雅史; 安井 由美子; 三瓶 雄司; 三上 奈々; 宮下 和夫; 田中 卓二, 日本栄養・食糧学会大会講演要旨集, 63回, 2009 05 |
| Aqueous and ethanolic extract fractions from the Brazilian propolis suppress azoxymethane-induced aberrant crypt foci in rats, Yumiko Yasui; Shingo Miyamoto; Mihye Kim; Hiroyuki Kohno; Shigeyuki Sugie; Takuji Tanaka, ONCOLOGY REPORTS, 20, (3) 493 - 499, 2008 09 , 10.3892/or_00000033 |
| A Novel Prodrug of 4 '-Geranyloxy-Ferulic Acid Suppresses Colitis-Related Colon Carcinogenesis in Mice, Shingo Miyamoto; Francesco Epifano; Massimo Curini; Salvatore Genovese; Mihye Kim; Rikako Ishigamori-Suzuki; Yumiko Yasui; Shigeyuki Sugie; Takuji Tanaka, NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 60, (5) 675 - 684, 2008 09 , 10.1080/01635580802008286 |
| AGFD 62-The suppression effects of conjugated linolenic acids on chemically induced colon carcinogenesis., Yumiko Yasui; Masashi Hosokawa; Kazuo Miyashita; Takuji Tanaka, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 236, 2008 08 |
| A lipophilic statin, pitavastatin, suppresses inflammation-associated mouse colon carcinogenesis, Yumiko Yasui; Rikako Suzuki; Shingo Miyamoto; Tetsuya Tsukamoto; Shigeyuki Sugie; Hiroyuki Kohno; Takuji Tanaka, INTERNATIONAL JOURNAL OF CANCER, 121, (10) 2331 - 2339, 2007 11 , 10.1002/ije.22976 |
| Global gene expression analysis of the mouse colonic mucosa treated with azoxymethane and dextran sodium sulfate, Rikako Suzuki; Shingo Miyamoto; Yumiko Yasui; Shigeyuki Sugie; Takuji Tanaka, BMC CANCER, 7, 2007 05 , 10.1186/1471-2407-7-84 |
| Chemopreventive effects of conjugated linolenic acids (CLN) occurring in plant seed oils, Bhaskar Narayan; Masashi Hosokawa; Yumiko Yasui; Rikako Suzuki; Hiroyuki Kohno; Takuji Tanaka; Kazuo Miyashita, Current Nutrition and Food Science, 3, (4) 309 - 318, 2007 , 10.2174/1573401310703040309 |
| Bitter gourd seed fatty acid rich in 9c,11t,13t-conjugated linolenic acid induces apoptosis and up-regulates the GADD45, p53 and PPARgamma in human colon cancer Caco-2 cells, YASUI Y, Prostaglandins Leukot Essent Fatty Acids, 73, 2005 |
| Dietary seed oil rich in conjugated linolenic acid from bitter melon inhibits azoxymethane-induced rat colon carcinogenesis through elevation of colonic PPAR gamma expression and alteration of lipid composition, H Kohno; Y Yasui; R Suzuki; M Hosokawa; K Miyashita; T Tanaka, INTERNATIONAL JOURNAL OF CANCER, 110, (6) 896 - 901, 2004 07 , 10.1002/ijc.20179 |
Research Grants & Projects
| Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Suppressing itching and extinguishing dermatitis with Pinaceae essential oil, 202404, 202703, 安井 由美子 |
| 日本学術振興会, 科学研究費助成事業, アカエゾマツの香りが妊娠・出産・成長に与える効果, 20220401, 20250331, 宮庄 拓; 前田 尚之; 安井 由美子 |
| Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Preventive effects of marine carotenoids on chronic inflammation-related diseases through regulation of cell and tissue communication, 20110401, 20140331, HOSOKAWA Masashi; YASUI Yumiko, Fucoxanthin (Fx) suppressed chronic inflammation in white adipose tissue by the inhibition of macrophage and T cell infiltration. Further, Fx down-regulated mRNA expression of chemokines and adipokines, which recruit immune cells and induce insulin resistance. In diabetic/obese mice fed Fx, GLUT4 activation was observed in skeletal muscle through the improvement of hyperglycemia. On the other hand, Fx and astaxanthin (Asx) extracted from H. pluvialis prevent DSS-induced colitis and colon carcinogenesis in mice. In colon of the mice fed Asx, mRNA expression levels of inflammatory cytokines tended to decrease compared to control mice. In addition, Asx down-regulated mRNA expression of inflammatory cytokines in macrophage-like cells and colon cells stimulated by the culture medium of activated macrophages. These results suggest that marine carotenoids prevent chronic inflammation and its-related diseases by the regulation of cell and tissue communication via chemokines and cytokines. |
| Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Analysis of the relation between prostate carcinognenesis targeted stem cells and inflammation, 2009, 2011, SUGIE Shigeyuki; TANAKA Takuji; YASUI Yumiko; OYAMA Takeru, In this study, the relation between prostate carcinogenesis and stem cell or inflammation is analyse in animal experimental carcinogenesis model targeted stem cells associated with prostatitis. Any prostate neoplasma were not found in any castrated rats, although prostate neoplasms was observed only in non-castration groups. From these results, the origin of cancer was assumed to be lost by castration. TP had a suppressive effect in PhIP prostate carcinogenesis. he hypothesis which Prostate cancer originated from stem cell. The lobes with inflammation were different the lobes with PIN. The modifying effect of inflammation for prostate carcinogenesis is not clear, yet. Further consideration will be necessary. |
| Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Involvement of obesity in oral carcinogenesis using animal models, 2008, 2010, TANAKA Takuji; SUGIE Shigeyuki; YASUI Yumiko, We investigated whether obesity influences oral (tongue) carcinogenesis using obese model animals, such as db/db and ob/ob mice. The results indicated that the obese mice were highly susceptible to 4-NQO-induced tongue and esophageal carcinogenesis when compared to their wild types (WT) of mice. In addition, the susceptibility was high in db/db mice in comparison with ob/ob mice. The immunohistochemical expression of pro-inflammatory cytokines (IL-1α, IL-1β, interleukin-4, interleukin-6, interleukin-8, and TNF-α) in the tongue squamous cell carcinomas which developed in the db/db mice were significantly greater than that developed in the WT mice (p<0.05-p<0.01). However, there were no significant differences in the expressions of NF-κB, Stat3, and Nrf2 between the obese and WT mice. Our results may suggest that overexpression of these pro-inflammatory cytokines plays an important role in highly susceptible to 4-NQO-induced tongue and esophageal carcinogenesis in obese mice. |
| Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Preventive effects of marine carotenoids on life-style-related diseases based on anti-inflammatory effects as molecular targets, 2008, 2010, HOSOKAWA Masashi; YASUI Yumiko, Astaxanthin exhibited inhibitory effects on dextran sodium sulfate-induced colitis and inflammatory-related colon carcinogenesis in mice. In colon of the mice fed astaxanthin, mRNA expression levels of inflammatory cytokines such as TNF-α and IL-1β were suppressed through inhibition of NF-κB activation. After feeding for 20 weeks, colonic mucosal ulcers, dysplastic crypts and colonic adenocarcinoma were inhibited by 200 ppm astaxanthin-containing diet. In addition, astaxanthin, pectenolone, alloxanthin and diatoxanthin isolated from marine organisms attenuated excessive mRNA expression of inflammatory cytokines and COX-2 and iNOS in macrophages activated by LPS. On the other hand, dietary 0.2% fucoxanthin markedly suppressed mRNA expression of inflammatory cytokines such as TNF-α and IL-6 to induce insulin resistance and inhibited macrophage infiltration in white adipose tissue through suppression of MCP-1 mRNA expression after 4 weeks feeding. Further, fucoxanthinol, which is one of fucoxanthin metabolites, also regulated cross talk of adipocytes and macrophages via palmitic acid and TNF-α. These results suggest that anti-inflammatory effects are molecular mechanism for anti-obesity and anti-diabetic effects of fucoxanthin. |
| 日本学術振興会, 科学研究費助成事業, 炎症性大腸発がんモデルマウスを用いた共役リノレン酸の発がん阻止効果に関する研究, 2006, 2007, 安井 由美子, 平成19年度は平成18年度に続き、20週目の剖検時における病理組織学的解析と、採取した大腸粘膜を用いて、発がんに関与する遺伝子の発現をリアルタイムPCRにて解析を行った。剖検時、いずれの実験群にも体重および肝重量に有意な差は見られなかった。一方、大腸の長さに関してはAOM+1.5% DSS+0.1% PGO群において、その他の群よりも、大腸が有意に短かった。大腸粘膜潰瘍と異型陰窩の発生に関して、AOM+1.5% DSS群と比較して、PGO処理によりいずれの濃度においても有意な(P<0.001)抑制が観察された。大腸腺腫の発生に関してはAOM+1.5% DSS群(0.9±1.10)で50%の発生が見られ、1% PGO処理(0.3±0.71)により抑制傾向が見られたものの有意な差は得られなかった。一方、腺がんの発生に関しては、AOM+1.5% DSS群(2.9±1.29)で90%の発生が見られ、いずれの濃度においても有意抑制効果が見られた(0.01% PGO:0.9±0.78,P<0.01,0.1% PGO:1.2±1.14,P<0.05,1%PGO:0.9±1.27,P<0.01)。さらに、大腸粘膜における発がん関連遺伝子(PPARγ、COX-2)の発現をリアルタイムPCRで解析した。その結果、20週時においてPGO処理によるPPARγの発現増加、COX-2の発現抑制の傾向が得られた。以上の結果から、CLNを高濃度含有するPGOは、炎症を背景とする大腸がんの発生を抑制することが明らかとなった。また、腺腫の発生に有意な差は見られず、腺がんの発生において顕著な抑制が見られたことから、特に腺腫から腺がんに進行するプログレッションの段階にPGOが作用することが示唆された。 |
| 天然物による発がん阻止とその機構解析, 2006 |
教員総覧