獣医学群・獣医保健看護学類
教員 及川伸 オイカワ シン
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更新日 :2020/09/01

研究者基本情報

氏名

及川伸
オイカワ シン

所属(マスタ)

獣医学群・獣医保健看護学類, 教員

所属・職名

獣医学群 獣医学類
教授

学位

博士(獣医学), 酪農学園大学
(BLANK), Rakuno Gakuen University

所属学協会

日本家畜衛生学会
日本産業動物獣医学会
獣医疫学会
日本獣医学会

研究活動情報

研究分野

ライフサイエンス, 獣医学
ライフサイエンス, 獣医学
ライフサイエンス, 獣医学
ライフサイエンス, 動物生産科学
ライフサイエンス, 動物生産科学

研究キーワード

飼養環境,
周産期疾患,
制御,
予防,
牛,
Veterinary Preventive Medicine,
Veterinary Internal Medicine,

論文

Effect of butyrate supplementation on the productivity of lactating dairy cows fed diets fiffering in starch content, Izumi, K, Fukumori, R, Oikawa, S, Oba, M, J. Dairy Sci., J. Dairy Sci., 102, 11051 - 11056,   2019年08月, 査読有り
血液中や乳汁中から容易に測定できるβ- ヒドロキシ酪酸濃度 〜潜在性ケトーシス対策にはモニタリングが重要, 及川 伸, Dairyman, Dairyman, 69, (8) 36 - 37,   2019年08月
Association of postpartum diseases occurring within 60 days after calving with productivity and reproductive performance in dairy cows in Fukuoka: A cow-level, retrospective cohort study., Goto, A, Takahara, K, Sugiura, T, Oikawa, S, Katamoto. H, Nakada, K, J. Vet. Med. Sci., J. Vet. Med. Sci., 81, (7) 1055 - 1062,   2019年07月, 査読有り
Increased serum malondialdehyde concentration in cows with subclinical ketosis, Senoh, R, Oikawa, S, Nakada, K, Tagami, T, Iwasaki, T, 日本獣医学会誌, 日本獣医学会誌, 81, (6) 817 - 820,   2019年06月, 査読有り
子牛の健康問題解決へのアプローチ, 及川 伸,   2019年02月
Peripartum metabolic profiles in a Holstein dairy herd with alarm level prevalence of subclinical ketosis detected in early lactation., Oikawa, S, 83, 50 - 56,   2019年01月, 査読有り
乳牛群の損害防止への新たなアプローチ, 及川 伸, 家畜診療, 家畜診療, 65, (4) 235 - 242,   2018年04月, 査読有り
乳牛のケトーシスにおける血中のNEFA濃度とBHBA濃度との関係, 及川 伸, 家畜診療, 家畜診療, 65, (3) 175 - 177,   2018年03月
Relevance of serum concentrations of non-esterified fatty acids and very low-density lipoproteins in nulli/primiparous and multiparous cows in the close-up period, Shin Oikawa, Haruka Saitoh-Okumura, Masaki Tanji, Ken Nakada, JOURNAL OF VETERINARY MEDICAL SCIENCE, JOURNAL OF VETERINARY MEDICAL SCIENCE, 79, (10) 1656 - 1659,   2017年10月, 査読有り
泌乳初期の潜在性ケトーシス牛に対する塩酸ベタイン製剤の投与効果, 加藤葉月, 安岡竜太, 及川伸, 中田健, 産業動物臨床医学雑誌, 産業動物臨床医学雑誌, 8, 7 - 17,   2017年07月, 査読有り
移行期におけるエネルギーバランスの管理, 及川 伸, 臨床獣医, 臨床獣医, 34, (8) 51 - 53,   2016年08月
RS感染が疑われた育成乳牛における血清LCAT活性値の意義, 家畜衛生学雑誌, 家畜衛生学雑誌, 42, (1) 11 - 18,   2016年05月, 査読有り
乳牛の潜在性ケトーシスの早期発見とその対策, 及川 伸, 酪農ジャーナル, 酪農ジャーナル, 69, (4) 22 - 24,   2016年04月
飼養管理と乾物摂取量〜現場で注意したいポイント〜, 及川 伸, 臨床獣医, 臨床獣医, 34, (2) 38 - 41,   2016年02月
Diagnostic and prognostic significance of serum gastrin and pepsinogen in dairy cows with displaded abomasum, Arafat Khalphallah, Enas Elmeligy, Ahmad A. Aamer, Shin Oikawa, Ken Nakada,   2016年01月, 査読有り
Herd health monitoring of dairy cows with displaced abomasum, Arafat Khalphallah, Enas Elmeligy, Hanan K Elsayed, Shin Oikawa, 3, (6) 402 - 405,   2016年, 査読有り
Diagnostic and Prognostic Significance of Lipid Profiles in Holstein Dairy Cattle with Displaced abomasum: Before and After Surgical Operation, J Adv Vet Res, J Adv Vet Res, 6, (1) 7 - 17,   2016年, 査読有り
Nutritional Indicators in Holstein Dairy Heifers Infected with Respiratory Syncytial Virus with Referring to Changes in Lipid Profile, Tumor Necrosis Factor-a and Acute Phase Proteins, 3, (1) 2 - 28,   2016年, 査読有り
Changes in serum lecithin: cholesterol acyltransferase and apolipoprotein B-100 in dairy cattle either with 1-7 Days in milk displaced abomasum or with 8-21 Days in milk displaced abomasum, Res Opin Anim Vet. Sci, Res Opin Anim Vet. Sci, 6, (8) 224 - 228,   2016年, 査読有り
Assessment of insulin and insulin resistance in dairy cattle with displaced abomasum pre and post-surgery, Scholar’s Adv Anim Vet Res, Scholar’s Adv Anim Vet Res, 2, (3) 162 - 176,   2015年, 査読有り
乳牛の潜在性ケトーシスに関する最近の研究動向, 及川 伸, 日本獣医師会雑誌, 日本獣医師会雑誌, 68, (1) 33 - 42,   2015年01月, 査読有り
乳牛の分房乳およにバルク乳検査における簡易型エンドトキシン測定システムの応用に関する基礎的調査, 三木康平, 平塚太志, 鈴木隆秀, 土谷正和, 及川伸, 中田健, 田村豊, 家畜衛生学雑誌, 家畜衛生学雑誌, 40, 7 - 12,   2014年04月, 査読有り
乳牛のケトーシス, 及川 伸, 4, (3) 117 - 124,   2013年11月, 査読有り
Effectiveness of isoprothiolane in preventing fatty liver in dairy cows., Jun A. Minaguchi1, Michisaburo Miura, Shin Oikawa, Fumi Handa, Takuya Haraguchi, Kazuyoshi Miyamoto-Ohno, Yuta Ito, Yoshinao Z. Hosaka1, Hiromi Ueda and Kazushige Takehana., Jun A. Minaguchi1, Michisaburo Miura, Shin Oikawa, Fumi Handa, Takuya Haraguchi, Kazuyoshi Miyamoto-Ohno, Yuta Ito, Yoshinao Z. Hosaka1, Hiromi Ueda and Kazushige Takehana., 7, 7 - 11,   2013年, 査読有り
Hepatocyte apoptosis in dairy cows with fatty infiltration of the liver, Mohamed Tharwat, Daiji Endoh, Shin Oikawa, RESEARCH IN VETERINARY SCIENCE, RESEARCH IN VETERINARY SCIENCE, 93, (3) 1281 - 1286,   2012年12月, 査読有り
乳牛のにおける第四胃変位の予察指標と飼養管理上の予防対策, 及川 伸, 臨床獣医, 臨床獣医, 30, (12) 45 - 48,   2012年12月
Hepatocyte apoptosis in dairy cattle during the transition period, Mohamed Tharwat, Aya Takamizawa, Yoshinao Z. Hosaka, Daiji Endoh, Shin Oikawa, CANADIAN JOURNAL OF VETERINARY RESEARCH-REVUE CANADIENNE DE RECHERCHE VETERINAIRE, CANADIAN JOURNAL OF VETERINARY RESEARCH-REVUE CANADIENNE DE RECHERCHE VETERINAIRE, 76, (4) 241 - 247,   2012年10月, 査読有り
乳牛のケトーシスとその対策, 及川 伸, 臨床獣医, 臨床獣医, 30, 44 - 49,   2012年09月
DMIを十分に確保させ牛群の健康を保つ/発情、受胎向上とエネルギーバランスの関連性, 及川 伸, デーリィマン, デーリィマン, 62, 62 - 63,   2012年06月
DNA damage in peripheral blood mononuclear cells and neutrophils of dairy cows during the transition period, 2, 65 - 68,   2012年, 査読有り
Ultrasonographic prediction of hepatic fat content in dairy cows during the transition period, Mohamed Tharwat, Shin Oikawa, Sébastien Buczinski, Journal of Veterinary Science and Technology, Journal of Veterinary Science and Technology, 3, (1) 1 - 5,   2012年, 査読有り
牛の肝臓疾患・脂肪肝, 及川 伸, 臨床獣医, 臨床獣医, 29, 52 - 57,   2011年12月
Ultrasonographic evaluation of cattle and buffaloes with respiratory disorders, Mohamed Tharwat, Shin Oikawa, TROPICAL ANIMAL HEALTH AND PRODUCTION, TROPICAL ANIMAL HEALTH AND PRODUCTION, 43, (4) 803 - 810,   2011年04月, 査読有り
DNA damage of blood lymphocytes and neutrophils in cattle with lymphosarcoma, T. Mohamed, D. Endoh, S. Oikawa, VETERINARNI MEDICINA, VETERINARNI MEDICINA, 56, (10) 504 - 509,   2011年, 査読有り
ハードヘルスから見た牛舎消毒の意義, 及川 伸, 酪農ジャーナル, 酪農ジャーナル, (11月) 12 - 14,   2011年
Changes of very low-density lipoprotein concentration in hepatic blood from cows with fasting-induced hepatic lipidosis, Shin Oikawa, Yuko Mizunuma, Yukari Iwasaki, Mohamed Tharwat, CANADIAN JOURNAL OF VETERINARY RESEARCH-REVUE CANADIENNE DE RECHERCHE VETERINAIRE, CANADIAN JOURNAL OF VETERINARY RESEARCH-REVUE CANADIENNE DE RECHERCHE VETERINAIRE, 74, (4) 317 - 320,   2010年10月, 査読有り
酪農場の生産性の分析による適正牛群評価法の検討, 松岡みずほ, 中田健, 及川 伸, 酪農学園大学紀要, 酪農学園大学紀要, 34, 185 - 196,   2010年, 査読有り
Comparison of serum lipid compositions, lipid peroxide, alpha-tocopherol and lipoproteins in captive marine mammals (bottlenose dolphins, spotted seals and West Indian manatees) and terrestrial mammals, Masahiko Kasamatsu, Rieko Kawauchi, Masatoshi Tsunokawa, Keiichi Ueda, Eiji Uchida, Shin Oikawa, Hidetoshi Higuchi, Takaaki Kawajiri, Senzo Uchida, Hajime Nagahata, RESEARCH IN VETERINARY SCIENCE, RESEARCH IN VETERINARY SCIENCE, 86, (2) 216 - 222,   2009年04月, 査読有り
乳牛の乾乳期における消化管内寄生線虫駆虫が分娩後の生産性に及ぼす影響, 栗栖睦幸, 栗原照夫, 及川 伸, 獣医畜産新報, 獣医畜産新報, 62, 363 - 369,   2009年
獣医師が体験した牛舎管理の善しあしー疾病予防における飼養環境の重要性—, 及川 伸, 酪農ジャーナル, 酪農ジャーナル, (8月) 12 - 14,   2008年08月

書籍等出版物

牛と人に優しい牛舎作り, 及川伸, 分担執筆, 高橋圭二監, 共著, 第1章 p24~32, 第4章 p152-156, デーリィマン社,   2018年10月
乳牛の周産期管理, 及川 伸, 単訳, 全訳 (151頁),   2018年09月
これからの乳牛群管理のためのハードヘルス学(成牛編), 及川 伸, 編者(編著者), 本の企画、編著者, 緑書房,   2017年12月
テレビドクター4 よく分かる乳牛の病気, 及川 伸, 分担執筆, ケトーシス、脂肪肝, デーリィマン社,   2017年10月
牛の乳房炎, 及川 伸, 共著, 英語の翻訳, デーリィマン社,   2016年09月
カウシグナルズチェックブック, 及川 伸, 中田 健 監訳, 共著, デーリィマン社,   2013年10月
牛の呼吸器病(訳本), 及川伸, 中田健, 監修,   2013年02月
牛は訴えている〜カウコンフォートの重要性〜, 及川伸, 三好志朗, 監修,   2013年02月
5. 乳牛群の健康管理のための環境モニタリング, 及川 伸, 監修, 酪農学園大学エクステンションセンター,   2011年03月

講演・口頭発表等

令和元年北海道家畜保健衛生所業績発表会審査, 及川 伸,   2019年10月24日
乳牛の血中BHBAおよびグルコース濃度の測定におけるヒト用ポータブル測定器の有用性, 村野夏穂, 福森理加, 吉村昌也, 田口尊之, 及川伸, 第162回日本獣医学会,   2019年09月11日
乳牛における酪酸塩の補給がSARA誘導時の炎症反応に及ぼす影響, 勝田遥香, 福森理加, 泉賢一, 大場真人, 及川伸, 第162回日本獣医学会,   2019年09月11日
泌乳牛における飼料中デンプン含量の違いと酪酸サプリメント給与の有無が血中GLP-2濃度と全消化管消化率に及ぼす影響, 山口峻太郎, 福森理加, 泉賢一, 大場真人, 及川伸, 第162回日本獣医学会,   2019年09月11日
第四胃変位および消化管線虫感染牛における血清中ペプシノーゲン濃度, 坂本李奈, 小口綾香, 福森理加, 高橋俊彦, 工藤克典, 及川伸, 第162回日本獣医学会,   2019年09月10日
酪農学園大学における欧州獣医学教育認証(EAEVE)への取り組み 日本獣医学会企画・司宰機関共催シンポジウム(第15回獣医学教育改革シンポジウム), 鈴木一由, 津川祐一, 篠原朱輝子, 長谷川泰子, 長谷川みちる, 能田淳, 山下和人, 及川伸, 第162回日本獣医学会,   2019年09月10日
乳牛のハードヘルス」宮崎県経済農業協同組合連合会生乳担当者会議研修会, 及川 伸,   2019年05月13日
平成30年度 全国酪農ヘルパー協会 酪農ヘルパー専門技術養成研修 初任者研修, 及川 伸,   2019年02月19日
平成30年度 全国酪農ヘルパー協会 酪農ヘルパー専門技術養成研修 中級者研修, 及川 伸,   2019年01月29日
乳牛のハードヘルスと生産性〜環境といモニタリングの重要性, 及川 伸, 乳業酪農 分析技術シンポジウム(スウェーデン大使館),   2018年11月28日, 招待有り
酪農場における血中NEFAとBHBA濃度測定システムの開発, 福森理加, 及川伸, 田口, 第30回牛病学会,   2018年08月30日
乳牛群の潜在性ケトーシスとその対策, 及川 伸, 平成30年度家畜診療技術発表会及び研修会,   2018年07月31日, 招待有り
酪農場の問題点へのアプローチ 〜乳牛群管理のためのハードヘルス学〜, 及川 伸, 第21回近畿しゃくなげ会技術研修会,   2018年07月06日, 招待有り
乳牛群の潜在性ケトーシスとその対策, 及川 伸, 北海道酪農検定検査協会研修会,   2018年02月28日, 招待有り
乳牛の疾病予防と対策, 及川 伸, 平成29年度 全国酪農ヘルパー協会 酪農ヘルパー専門技術養成研修 初任者研修,   2018年02月22日
乳牛の疾病予防と対策, 及川 伸, 平成29年度 全国酪農ヘルパー協会 酪農ヘルパー専門技術養成研修 中級者研修,   2018年02月01日, 招待有り
離乳前後における中鎖脂肪酸カルシウムの給与が子牛のインスリン分泌・作用に及ぼす影響, 福森理加, 増田洋史, 杉野利久, 及川伸, 長尾慶和, 第160回日本獣医学会、鹿児島大学(鹿児島市),   2017年09月15日
乳用牛群の繁殖性評価項目の特徴と利用方法についてー北海道乳用牛群検定データ分析—, 中田健, 及川伸, 森好政晴, 第160回日本獣医学会、鹿児島大学(鹿児島市),   2017年09月13日
平成28年度 全国酪農ヘルパー協会 酪農ヘルパー中級者養成研修, 及川 伸,   2017年02月01日, 招待有り
乳牛群におけるケトーシス対策のポイント, 及川 伸, 明治飼糧(株)酪農セミナー,   2016年09月27日, 招待有り
連産する乳牛の初産時の繁殖および生産の特徴—浜中研究—, 中田健, 高崎裕一, 及川伸, 第158回日本獣医学会,   2016年09月
乳牛における胎盤停滞の予察マーカーとしての血清Lecithin:cholesterol acyltransferase活性値, 佐藤宏樹, 及川伸, 中田健, 畠悠起, 小野奨平, 第158回日本獣医学会,   2016年09月
泌乳初期の潜在性ケトーシス牛における分娩前後のインスリン抵抗性, 千里今日子, 柴田千穂子, 佐藤宏樹, 及川伸, 中田健, 第158回日本獣医学会,   2016年09月
子牛における体表温センサの臨床応用に関する基礎的調査, 前田みどり, 宮本亨, 高橋雄治, 茅先秀司, 竹内未来, 佐藤宏樹, 千里今日子, 中田健, 及川 伸, 第158回日本獣医学会,   2016年09月
乳牛の疾病予防と対策, 及川 伸, 平成27年度 全国酪農ヘルパー協会 酪農ヘルパー初任者養成研修,   2016年02月16日, 招待有り
乳牛の疾病予防と対策, 及川 伸, 平成27年度 全国酪農ヘルパー協会 酪農ヘルパー中級者養成研修,   2016年01月27日, 招待有り

作品

ウシの脂肪肝の脂肪肝におけるアポトーシスに関する基礎的研究,   2004年 - 2005年
A Study on Apoptosis of liver in cows with fatty liver,   2004年 - 2005年
家畜の感染症、生産病の分子・遺伝子レベルでの病態解析と診断・治療法の開発,   1998年 - 2002年
The Molecular Biological and Genetical Analyses of Infections Diseases and Production Diseases in Domestic Animals and the Developments of Their Diagnoses and Treatments,   1998年 - 2002年
ウシの脂肪肝の発生機序に関する基礎的研究,   2002年
A Basic Study on Meehanism of Occurence of Fatty Liver in Cattle,   2002年
ウシの脂肪肝におけるインスリン抵抗性とTNFαとの関連に関する基礎的研究,   2000年 - 2001年
A Basic Study on the Relevance between Insulin Resistance and Tumor Necrosis Factor-α in Cows with Fatty Liver,   2000年 - 2001年
ウシの脂肪肝における熱ショックタンパク質の発現に関する基礎的研究,   1999年 - 2000年
A Basic Approach to Heat Shock Protein in Bovine Fatty Liver,   1999年 - 2000年

MISC

乳牛の生産病予防と飼養環境, 及川伸, 獣医畜産新報, 61,   2008年
酪農学園大学におけるプロダクションメディスン教育, 及川伸, 家畜診療, 55,   2008年
Assessment of serum pepsinogen and other biochemical parameters in dairy cows with displaced abomasums or abomasal volvulus before and after operation., J. Rakyno, Gakuen. Uni, Abouzeid, N, Z., Sakuta, E., Kawai, T., Takahashi, T., Gotoh, A., Takehana, K. and Oikawa, S., 32,   2008年
Efficacy and safety of ultrasound-guided percutaneous biopsy of the right kidney in cattle, Mohamed, T, Oikawa, S, J. Vet. Med. Sci., 70, (2) 175 - 179,   2008年, 10.1292/jvms.70.175
Assessment of serum pepsinogen and other biochemical parameters in dairy cows with displaced abomasums or abomasal volvulus before and after operation., Abouzeid, N, Z, Sakuta, E, Kawai, T, Takahashi, T, Gotoh, A, Takehana, K, Oikawa, S, J. Rakyno. Gakuen. Uni., 32,   2008年
Efficacy and safety of ultrasound-guided percutaneous biopsy of the right kidney in cattle., Mohamed, T, Oikawa, S, J. Vet. Med. Sci., 70, (2) 175 - 179,   2008年, 10.1292/jvms.70.175
教育現場におけるプロダクションメディスンのこれからム米国ウイスコンシン州立大学の実践例, 及川伸, 家畜診療, 54,   2007年
Ultrasonographic Characteristics of Abdominal and Thoracic Abscesses in Cattle and Buffaloes., Mohamed, T, Oikawa, S, J. Vet. Med. A, 54,   2007年, 10.1111/j.1439-0442.2007.00989.x
Ultrasonographic Characteristics of Abdominal and Thoracic Abscesses in Cattle and Buffaloes., Mohamed, T, Oikawa, J. Vet. Med. A, 54,   2007年, 10.1111/j.1439-0442.2007.00989.x
Decreased insulin response in dairy cows following a four-day fast to induce hepatic lipidosis, S. Oikawa, G. R. Oetzel, JOURNAL OF DAIRY SCIENCE, 89, (8) 2999 - 3005,   2006年08月, Negative energy balance has been implicated in the development of fatty liver, insulin resistance, and impaired health in dairy cows. A 4-d fasting model previously was reported to increase liver triglycerides more than 2.5-fold. The purpose of the present study was to evaluate insulin response in this fasting model. Nonlactating, nonpregnant Holstein cows were fasted for 4 d ( 6 cows) or fed continuously as control cows ( 4 cows). Samples were collected 5 d before fasting, during fasting, and immediately after the 4-d fast, 8 d after the fast, and 16 d after the fast. Fasted cows had greater liver triglyceride content ( 49.4 vs. 16.2 mg/g, wet-weight basis) at the end of the fasting period compared with control cows. Fasted cows also had increased plasma nonesterified fatty acid ( NEFA) concentrations ( 1.24 vs. 0.21 mmol/L) and increased plasma beta-hydroxybutyrate ( BHBA) concentrations at the end of the fasting period. Liver triglyceride, plasma NEFA, and plasma BHBA in fasted cows returned to prefasting concentrations by the end of the experiment. Plasma glucose concentrations were not affected by fasting. Plasma insulin concentrations were decreased ( 6.3 vs. 14.1 mu U/mL) and insulin-stimulated blood glucose reduction was decreased ( 24.9 vs. 48.6%) in the fasted cows compared with control cows at the end of the fast, indicating reduced insulin response. Insulin response was negatively correlated with plasma NEFA and liver triglycerides. Decreased insulin response may be an important complication of negative energy balance and hepatic lipidosis.
Decreased insulin response in dairy cows following a four-day fast to induce hepatic lipidosis, S. Oikawa, G. R. Oetzel, JOURNAL OF DAIRY SCIENCE, 89, (8) 2999 - 3005,   2006年08月, Negative energy balance has been implicated in the development of fatty liver, insulin resistance, and impaired health in dairy cows. A 4-d fasting model previously was reported to increase liver triglycerides more than 2.5-fold. The purpose of the present study was to evaluate insulin response in this fasting model. Nonlactating, nonpregnant Holstein cows were fasted for 4 d ( 6 cows) or fed continuously as control cows ( 4 cows). Samples were collected 5 d before fasting, during fasting, and immediately after the 4-d fast, 8 d after the fast, and 16 d after the fast. Fasted cows had greater liver triglyceride content ( 49.4 vs. 16.2 mg/g, wet-weight basis) at the end of the fasting period compared with control cows. Fasted cows also had increased plasma nonesterified fatty acid ( NEFA) concentrations ( 1.24 vs. 0.21 mmol/L) and increased plasma beta-hydroxybutyrate ( BHBA) concentrations at the end of the fasting period. Liver triglyceride, plasma NEFA, and plasma BHBA in fasted cows returned to prefasting concentrations by the end of the experiment. Plasma glucose concentrations were not affected by fasting. Plasma insulin concentrations were decreased ( 6.3 vs. 14.1 mu U/mL) and insulin-stimulated blood glucose reduction was decreased ( 24.9 vs. 48.6%) in the fasted cows compared with control cows at the end of the fast, indicating reduced insulin response. Insulin response was negatively correlated with plasma NEFA and liver triglycerides. Decreased insulin response may be an important complication of negative energy balance and hepatic lipidosis.
牛群検定(乳検)グラフ作成ソフトの構築., 遠藤大二, 及川伸, 泉賢一, 香山成哲, 後藤文, 酪農学園大学紀要, 31,   2006年
Changes of blood biochemical values in ponies recovering from hyperlipemia in Japan., Oikawa, S, McGuirk, S, Nishibe, K, Higuchi, T, Kurosawa, T, Watanuki, M, Satoh, H, J. Vet. Med. Sci. 68:353-359., 68, (4) 353 - 359,   2006年, 10.1292/jvms.68.353
Changes of blood biochemical values in ponies recovering from hyperlipemia in Japan., Oikawa, S, McGuirk, S, Nishibe, K, Higuchi, T, Kurosawa, T, Watanuki, M, Satoh, H, J. Vet. Med. Sci., 68, (4) 353 - 359,   2006年, 10.1292/jvms.68.353
本学附属農場牛群データを共有するためのWebデータベースシステムの構築., 遠藤大ニ, 泉賢一, 及川伸, 酪農学園大学紀要, 29,   2005年
北海道の放牧育成牛における血清ペプシノーゲン値と糞便中の消化管内寄生線虫卵数の調査., 及川伸, 昆野雄介, 高橋俊彦, 太田浩運, 望月理衣子, 黒澤隆, 福本真一郎, 佐藤博, 日本獣医師会雑誌. 58: 387-390., 58,   2005年, 10.12935/jvma1951.58.387
Bovine paraoxonase 1 activities in serum and distribution in lipoproteins., Miyamoto, T, Takahashi, Y, Oohashi, T, Sato, K, Oikawa, S, J. Vet. Med. Sci., 67, (3) 243 - 248,   2005年, 10.1292/jvms.67.243
Bovine paraoxonase 1 activities in serum and distribution in lipoproteins., Miyamoto, T, Takahashi, Y, Oohashi, T, Sato, K, Oikawa, J. Vet. Med. Sci., 67, (3) 243 - 248,   2005年, 10.1292/jvms.67.243
Ultrasonographic diagnosis of omasal leiomyoma in a cow, T Mohamed, S Oikawa, M Koiwa, H Sato, T Kurosawa, VETERINARY RECORD, 155, (17) 530 - 531,   2004年10月
Ultrasonographic diagnosis of omasal leiomyoma in a cow, T Mohamed, S Oikawa, M Koiwa, H Sato, T Kurosawa, VETERINARY RECORD, 155, (17) 530 - 531,   2004年10月
Ultrasonographic localisation of thrombi in the caudal vena cava and hepatic veins in a heifer, T Mohamed, H Sato, T Kurosawa, S Kawa, VETERINARY JOURNAL, 168, (1) 103 - 106,   2004年07月, 10.1016/S1090-0233(03)00076-5
Ultrasonographic localisation of thrombi in the caudal vena cava and hepatic veins in a heifer, T Mohamed, H Sato, T Kurosawa, S Kawa, VETERINARY JOURNAL, 168, (1) 103 - 106,   2004年07月, 10.1016/S1090-0233(03)00076-5
Focal fatty liver in a heifer: Utility of ultrasonography in diagnosis, Tharwat Mohamed, Shin Oikawa, Takashi Kurosawa, Kazushige Takehana, Yoshinao Hosaka, Hiroyuki Okada, Masateru Koiwa, Hiroshi Sato, Journal of Veterinary Medical Science, 66, (3) 341 - 344,   2004年03月, 10.1292/jvms.66.341, A 30-month-old Holstein heifer presented with a history of decreased appetite and respiratory signs. Sonographic examination of the liver incidentally revealed an area of increased echogenicity between the portal vein and the gallbladder. The lesion was non-spherical and had no mass effect or displacement of the adjacent vessels. Its boundaries, to the liver, were geographic. The liver specimen was histologically compatible with a diagnosis of focal fatty liver change (FFLC). The sonographic features of focal fatty infiltration of the liver are characteristic. Recognition of the ultrasonographic data is important to differentiate FFLC from other lesions.
脂肪肝牛における血清中ビタミンA濃度と肝臓星細胞の関連性., 小川美希, 今井克幸, 及川伸, 保坂善真, 植田弘美, 竹花一成, 日本獣医師会雑誌, 57,   2004年, 10.12935/jvma1951.57.639
Anticoccidal efficacy of medium-chain triglycerides (MCT) in calves., Sato, H, Nitanai, A, Kurosawa, T, Oikawa, S, J. Vet. Med. Sci., 66, (12) 1583 - 1585,   2004年, 10.1292/jvms.66.1583
酪農学園大学附属農場における疾病発生に関する疫学的調査., 嶋拓也, 及川伸, 泉賢一, 遠藤大ニ, 寺脇良悟, 菊池直哉, 黒澤隆, 佐藤博, 中田健, 小岩政照, 田口清, 酪農学園大学紀要, 29,   2004年
Decreases in serum apolipoprotein C-III concentration in cows with ethionine-induced fatty liver., Nitanai, A, Katoh, N, Oikawa, S, Saitoh, M, Hamada, M, Kutsuzawa, A, Mohamed, T, Uchida, E, Endoh, D, Kurosawa, T, Sato, H, J. Vet. Med. Sci., 66, (9) 1113 - 1118,   2004年, 10.1292/jvms.66.1113
Metabolic profiles and bile acid extraction rate in the liver of cows with fasting-induced hepatic lipidosis., Mohamed, T, Oikawa, S, Iwasaki, Y, Mizunuma, Y, Takehana, K, Endoh, D, Kurosawa, T, Sato, H, J. Vet. Med. A, 55,   2004年, 10.1111/j.1439-0442.2004.00614.x
Focal fatty liver in a heifer: utility of ultrasonography in diagnosis., Mohamed, T, Oikawa, S, Kurosawa, T, Takehana, K, Hosaka, Y, Okada, H, Koiwa, M, Sato, H, J. Vet. Med. Sci., 66, (3) 341 - 344,   2004年, 10.1292/jvms.66.341
Tetralogy of fallot in a calf: clinical, ultrasonographic, laboratory and postmortem findings., Mohamed, T, Sato, H, Kurosawa, T, Oikawa, S, Nakade, T, Koiwa, M, J. Vet. Med. Sci., 66, (1) 73 - 76,   2004年, 10.1292/jvms.66.73
Fatty acid profiles in relation to triglyceride level in the liver of dairy cows., Sato, H, Mohamed, T, Goto, A, Oikawa, S, Kurosawa, T, J. Vet. Med. Sci., 66, (1) 85 - 87,   2004年, 10.1292/jvms.66.85
Anticoccidal efficacy of medium-chain triglycerides (MCT) in calves., Sato, H, Nitanai, A, Kurosawa, T, Oikawa, J. Vet. Med. Sci., 66, (12) 1583 - 1585,   2004年, 10.1292/jvms.66.1583
Decreases in serum apolipoprotein C-III concentration in cows with ethionine-induced fatty liver., J. Vet, Med. Sci, Nitanai, A., Katoh, N., Oikawa, S., Saitoh, M., Hamada, M., Kutsuzawa, A., Mohamed, T., Uchida, E., Endoh, D., Kurosawa, T. and Sato, H., 66, (9) 1113 - 1118,   2004年, 10.1292/jvms.66.1113
Metabolic profiles and bile acid extraction rate in the liver of cows with fasting-induced hepatic lipidosis., Mohamed, T, Oikawa, S, Iwasaki, Y, Mizunuma, Y, Takehana, K, Endoh, D, Kurosawa, T, Sato, H, J. Vet. Med. A, 55,   2004年, 10.1111/j.1439-0442.2004.00614.x
Tetralogy of fallot in a calf: clinical, ultrasonographic, laboratory and postmortem findings., Mohamed, T, Sato, H, Kurosawa, T, Oikawa, S, Nakade, T, Koiwa, M, J. Vet. Med. Sci., 66, (1) 73 - 76,   2004年, 10.1292/jvms.66.73
Fatty acid profiles in relation to triglyceride level in the liver of dairy cows., Sato, H, Mohamed, T, Goto, A, Oikawa, S, Kurosawa, T, J. Vet. Med. Sci., 66, (1) 85 - 87,   2004年, 10.1292/jvms.66.85
Transcutaneous ultrasound-guided pancreatic biopsy in cattle and its safety: a preliminary report, T Mohamed, H Sato, T Kurosawa, S Oikawa, VETERINARY JOURNAL, 166, (2) 188 - 193,   2003年09月, 10.1016/S1090-0233(03)00027-3, This study describes a free-hand technique for percutancous pancreatic biopsy in cattle with ultrasound-guidance using a 14G spinal biopsy needle. Its safety was evaluated based on 36 consecutive procedures. To assess the immediate effects of pancreatic biopsy, 31 cows were necropsied shortly after the procedure and examined. The remaining five cows were examined daily for eight days and then necropsied and examined. No life-threatening complications nor clinically detectable abnormalities were observed. Changes indicative of inflammation were not apparent in total and differential WBC counts or in total protein and fibrinogen concentrations. A small increase of amylase activity was detected in only one cow kept for the eight-day observation period. Serum lipase activity increased significantly on day four after biopsy. Urea nitrogen, creatinine, glucose and the activities of aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyltransferase remained within reference ranges. Changes in the peritoneum and pancreas observed at necropsy were negligible. We conclude that percutaneous ultrasound-guided pancreatic biopsy did not appear to influence the cow's condition adversely and the procedure provided an excellent method of obtaining a pancreatic specimen for histological examination. The procedure was considered safe, fast, cost-effective, and practical when performed properly. We believe that the technique can be used in cows with suspected pancreatic disease for making an ante mortern diagnosis. (C) 2003 Elsevier Science Ltd. All rights reserved.
Transcutaneous ultrasound-guided pancreatic biopsy in cattle and its safety: a preliminary report, T Mohamed, H Sato, T Kurosawa, S Oikawa, VETERINARY JOURNAL, 166, (2) 188 - 193,   2003年09月, 10.1016/S1090-0233(03)00027-3, This study describes a free-hand technique for percutancous pancreatic biopsy in cattle with ultrasound-guidance using a 14G spinal biopsy needle. Its safety was evaluated based on 36 consecutive procedures. To assess the immediate effects of pancreatic biopsy, 31 cows were necropsied shortly after the procedure and examined. The remaining five cows were examined daily for eight days and then necropsied and examined. No life-threatening complications nor clinically detectable abnormalities were observed. Changes indicative of inflammation were not apparent in total and differential WBC counts or in total protein and fibrinogen concentrations. A small increase of amylase activity was detected in only one cow kept for the eight-day observation period. Serum lipase activity increased significantly on day four after biopsy. Urea nitrogen, creatinine, glucose and the activities of aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyltransferase remained within reference ranges. Changes in the peritoneum and pancreas observed at necropsy were negligible. We conclude that percutaneous ultrasound-guided pancreatic biopsy did not appear to influence the cow's condition adversely and the procedure provided an excellent method of obtaining a pancreatic specimen for histological examination. The procedure was considered safe, fast, cost-effective, and practical when performed properly. We believe that the technique can be used in cows with suspected pancreatic disease for making an ante mortern diagnosis. (C) 2003 Elsevier Science Ltd. All rights reserved.
Ultrasonographic Imaging of experimentally induced pancreatitis in cattle, T Mohamed, H Sato, T Kurosawa, S Oikawa, A Nitanai, VETERINARY JOURNAL, 165, (3) 314 - 324,   2003年05月, 10.1016/S1090-0233(02)00179-X, This study was conducted to determine the ultrasonographic patterns of pancreatitis evoked in cattle, with reference to laboratory and pathological findings. Using ultrasonographic guidance, acute necrotizing pancreatitis was induced in six cows by injecting chloroform into the pancreatic tissue. Ultrasonographic examination was then performed once daily for nine days. Pancreatic lesions were visible 24 h after induction of pancreatitis, as represented by a uniform increase in echogenicity and by intralobular and subcapsular fluid accumulation. As the experiment progressed, patchy hypoechogenic foci appeared within the gland parenchyma. Amylase and lipase activities showed rapid increases. Post mortem examination revealed gross and microscopic necrotic and haemorrhagic lesions in the body and right lobe of the pancreas, accompanied by oedema and fibrosis. Ultrasonography was found to be extremely useful for the detection and characterization of experimentally induced pancreatitis and to monitor its progression in the cow. These findings are of potential value as a reference for the diagnostic workup of bovine pancreatitis, and ultrasonography is seen as a promising non-invasive technique for the diagnosis of suspected pancreatitis in cattle. (C) 2002 Elsevier Science Ltd. All rights reserved.
Ultrasonographic Imaging of experimentally induced pancreatitis in cattle, T Mohamed, H Sato, T Kurosawa, S Oikawa, A Nitanai, VETERINARY JOURNAL, 165, (3) 314 - 324,   2003年05月, 10.1016/S1090-0233(02)00179-X, This study was conducted to determine the ultrasonographic patterns of pancreatitis evoked in cattle, with reference to laboratory and pathological findings. Using ultrasonographic guidance, acute necrotizing pancreatitis was induced in six cows by injecting chloroform into the pancreatic tissue. Ultrasonographic examination was then performed once daily for nine days. Pancreatic lesions were visible 24 h after induction of pancreatitis, as represented by a uniform increase in echogenicity and by intralobular and subcapsular fluid accumulation. As the experiment progressed, patchy hypoechogenic foci appeared within the gland parenchyma. Amylase and lipase activities showed rapid increases. Post mortem examination revealed gross and microscopic necrotic and haemorrhagic lesions in the body and right lobe of the pancreas, accompanied by oedema and fibrosis. Ultrasonography was found to be extremely useful for the detection and characterization of experimentally induced pancreatitis and to monitor its progression in the cow. These findings are of potential value as a reference for the diagnostic workup of bovine pancreatitis, and ultrasonography is seen as a promising non-invasive technique for the diagnosis of suspected pancreatitis in cattle. (C) 2002 Elsevier Science Ltd. All rights reserved.
牛における潜在性ケトーシスと脂肪肝, 及川伸, 臨床獣医, 21,   2003年
乳用子牛の糞中アンモニア、尿素および有機酸濃度と下痢との関係., 佐藤博, 黒澤隆, 及川伸, 日獣会誌, 56,   2003年, 10.12935/jvma1951.56.517
Mohamed, T., Oikawa, S., Nakada, K., Kurosawa, T., Sawamukai, Y. Percutaneous ultrasound-guided over-the-wire catheterization of the portal and hepatic vessels in cattle., Mohamed, T, Oikawa, S, Nakada, K, Kurosawa, T, Sawamukai, Y, Sato, H, J. Vet. Med. Sci., 65, (7) 821 - 824,   2003年, 10.1292/jvms.65.821
Percutaneous ultrasound-guided over-the-wire catheterization of the portal and hepatic vessels in cattle., Mohamed, T, Oikawa, S, Nakada, K, Kurosawa, T, Sawamukai, Y, Sato, H, J. Vet. Med. Sci., 65, (7) 821 - 824,   2003年, 10.1292/jvms.65.821
Bile acid extraction rate in the liver of cows fed high-fat diet and lipid profiles in the portal and hepatic veins, T Mohamed, H Sato, T Kurosawa, S Oikawa, JOURNAL OF VETERINARY MEDICINE SERIES A-PHYSIOLOGY PATHOLOGY CLINICAL MEDICINE, 49, (3) 151 - 156,   2002年04月, The purposes of this study are to assess the responses of increased supplemental dietary fat in the cow, without upsetting rumen fermentation, on the bile acid (BA) extraction rate in the liver and to determine whether this diet would affect the postprandial lipid profiles in the portal and hepatic venous blood. Six Holstein cows were equipped with catheters fitted in the portal and hepatic veins. Two cows each were assigned randomly to a sequence of three dietary treatments of 21-day period. The methodology of this study was based on the supplementation of the basal concentrate diet with 0 (control), 5, or 10% calcium salts of fatty acids (CSFA), The total bile acids were significantly increased in the portal and hepatic veins with the 5% CSFA diet, whereas no increase occurred with the 10% CSFA diet. Data obtained in this study showed that 10% CSFA diet failed to stimulate BA secretion to exceed the values obtained with 5% CSFA-diet. Moreover, there was no change in the hepatic extraction rate of BA in animals fed either the 0 or 5% CSFA diets which ranged from 2.4 to 6.5-fold and 3.1 to 7.3-fold, respectively. However, the extraction rate increased sharply with the 10% CSFA diet (27-fold). The median portal and hepatic concentrations of total lipids, triglycerides, total cholesterol, phospholipids and non-esterified fatty acids did not show any significant increase during feeding of the control diet. Moreover, feeding either the 5 or 10% CSFA diet did not significantly increase these values in either vein.
Bile acid extraction rate in the liver of cows fed high-fat diet and lipid profiles in the portal and hepatic veins, T Mohamed, H Sato, T Kurosawa, S Oikawa, JOURNAL OF VETERINARY MEDICINE SERIES A-PHYSIOLOGY PATHOLOGY CLINICAL MEDICINE, 49, (3) 151 - 156,   2002年04月, The purposes of this study are to assess the responses of increased supplemental dietary fat in the cow, without upsetting rumen fermentation, on the bile acid (BA) extraction rate in the liver and to determine whether this diet would affect the postprandial lipid profiles in the portal and hepatic venous blood. Six Holstein cows were equipped with catheters fitted in the portal and hepatic veins. Two cows each were assigned randomly to a sequence of three dietary treatments of 21-day period. The methodology of this study was based on the supplementation of the basal concentrate diet with 0 (control), 5, or 10% calcium salts of fatty acids (CSFA), The total bile acids were significantly increased in the portal and hepatic veins with the 5% CSFA diet, whereas no increase occurred with the 10% CSFA diet. Data obtained in this study showed that 10% CSFA diet failed to stimulate BA secretion to exceed the values obtained with 5% CSFA-diet. Moreover, there was no change in the hepatic extraction rate of BA in animals fed either the 0 or 5% CSFA diets which ranged from 2.4 to 6.5-fold and 3.1 to 7.3-fold, respectively. However, the extraction rate increased sharply with the 10% CSFA diet (27-fold). The median portal and hepatic concentrations of total lipids, triglycerides, total cholesterol, phospholipids and non-esterified fatty acids did not show any significant increase during feeding of the control diet. Moreover, feeding either the 5 or 10% CSFA diet did not significantly increase these values in either vein.
Micromorphological characteristics of hepatic sinusoidal endothelial cells and their basal laminae in five different animal species, Nobuyo Higashi, Hiromi Ueda, Osamu Yamada, Shin Oikawa, Masateru Koiwa, Prasarn Tangkawattana, Kazushige Takehana, Okajimas Folia Anatomica Japonica, 79, (5) 135 - 142,   2002年, 10.2535/ofaj.79.135, The micromorphological characteristics of hepatic sinusoidal endothelial cells and their basal laminae in five different animal species (cow, sheep, guinea pig, pig, and dog) were studied by electron microscopy. Using transmission electron microscopy, a prominent basal lamina was seen only in cow and sheep. In pig and guinea pig, no prominent basal lamina was evident. Basal lamina-like material was occasionally found in dog. Immunohistochemically, basal lamina was found in cow, sheep, and dog. Using scanning electron microscopy, the size of endothelial fenestrae differed between species. These results may suggest that variation of endothelia and their basal laminae of different species is related to differences in nourishment.
ケトーシス発症乳牛における肝脂肪化と類洞内皮細胞下基底膜との関係, 岸基史, 東伸好, 保坂善真, 植田弘美, 及川伸, 小岩政照, 竹花一成, 家畜診療, 49,   2002年
Complex vertebral malformation in a stillborn Holstein calf in Japan. 64:1107-1112., Nagahata, H, Oota, H, Nitanai, A, Oikawa, S, Higuchi, H, Nakade, T, Kurosawa, T, Morita, M, Ogawa, H, J. Vet. Med. Sci., 64, (12) 1107 - 1112,   2002年, 10.1292/jvms.64.1107
Acetic acid and 3-hydroxybutyric acid levels in cerebrospinal fluid of cattle., SATO H, KUROSAWA T, OIKAWA S, Ani.Sci.J., 73, (2) 137 - 141,   2002年, 10.1046/j.1344-3941.2002.00020.x
新生子馬における糞中にVFA,乳酸濃度の推移, 日本獣医師会雑誌, 55,   2002年, 10.12935/jvma1951.55.417
公共育成牧場の評価と預託のメリット, Dairyman, 52,   2002年
Serum pepsinogen concentrations in healthy cows and their diagnostic significcance with abomasal diseases., J. Rakuno Gakuen Uni., 26,   2002年
超音波ガイド法によるウシの肝門脈、肝静脈血の採取とその成分の検討, 日畜会報, 73,   2002年, 10.2508/chikusan.73.33
Decreases in serum apolipoprotein B-100 and A-I concentrations in cows with milk fever and downer cows., Can.J.Vet.Res., 66,   2002年
Decreases of apolipoprotein B-100 and A-I concentrations and induction of haptoglogin and serum amyloid A in nonfed calves., KATOH N, OIKAWA S, OOHASHI T, TAKAHASHI Y, ITOH F, J.Vet.Med.Sci., 64, (1) 51 - 55,   2002年, 10.1292/jvms.64.51
Echo-guided studies on portal and hepatic blood in cattle., J.Vet.Med.Sci., 64, (1) 23 - 28,   2002年, 10.1292/jvms.64.23
一公共放牧地における過去6年間にわたる乳用牛育成の多角的評価(2), 畜産の研究, 56,   2002年
一公共放牧地における過去6年間にわたる乳用牛育成の多角的評価(1), 畜産の研究, 56,   2002年
Micromorphological characteristics of hepatic sinusoidal endothelial cells and their basal laminae in five different animal species, Nobuyo Higashi, Hiromi Ueda, Osamu Yamada, Shin Oikawa, Masateru Koiwa, Prasarn Tangkawattana, Kazushige Takehana, Okajimas Folia Anatomica Japonica, 79, (5) 135 - 142,   2002年, 10.2535/ofaj.79.135, The micromorphological characteristics of hepatic sinusoidal endothelial cells and their basal laminae in five different animal species (cow, sheep, guinea pig, pig, and dog) were studied by electron microscopy. Using transmission electron microscopy, a prominent basal lamina was seen only in cow and sheep. In pig and guinea pig, no prominent basal lamina was evident. Basal lamina-like material was occasionally found in dog. Immunohistochemically, basal lamina was found in cow, sheep, and dog. Using scanning electron microscopy, the size of endothelial fenestrae differed between species. These results may suggest that variation of endothelia and their basal laminae of different species is related to differences in nourishment.
Complex vertebral malformation in a stillborn Holstein calf in Japan., Nagahata, H, Oota, H, Nitanai, A, Oikawa, S, Higuchi, H, Nakade, T, Kurosawa, T, Morita, M, Ogawa, H, J. Vet. Med. Sci., 64, (12) 1107 - 1112,   2002年, 10.1292/jvms.64.1107
Acetic acid and 3-hydroxybutyric acid levels in cerebrospinal fluid of cattle., Ani.Sci.J., 73, (2) 137 - 141,   2002年, 10.1046/j.1344-3941.2002.00020.x
Serum pepsinogen concentrations in healthy cows and their diagnostic significcance with abomasal diseases., J. Rakuno Gakuen Uni., 26,   2002年
Decreases in serum apolipoprotein B-100 and A-I concentrations in cows with milk fever and downer cows., Can.J.Vet.Res., 66,   2002年
Decreases of apolipoprotein B-100 and A-I concentrations and induction of haptoglogin and serum amyloid A in nonfed calves., J.Vet.Med.Sci., 64, (1) 51 - 55,   2002年, 10.1292/jvms.64.51
Echo-guided studies on portal and hepatic blood in cattle., Tharwat MOHAMED, Hiroshi SATO, Takashi KUROSAWA, Shin OIKAWA, J.Vet.Med.Sci., 64, (1) 23 - 28,   2002年, 10.1292/jvms.64.23
Molecular cloning of bovine (Bos taurus) cDNA encoding a 94-kDa glucose-regulated protein and developmental changes in its mRNA and protein content in the mammary gland, A Watanabe, Uchida, I, K Nakata, Y Fujimoto, S Oikawa, COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 130, (4) 547 - 557,   2001年12月, 10.1016/S1096-4959(01)00464-X, We isolated and sequenced cDNA clones encoding a 94-kDa glucose-regulated protein (GRP94) from a cDNA library constructed using bovine (Bos taurus) mammary gland poly(A) I RNA. The coding nucleotide sequence and the deduced amino acid sequence of bovine GRP94 shared 94.2-88.4% and 98.1-96.5% identity with those of other mammalian species, respectively. The primary structure contained a carboxyl-terminal signal sequence for retention in the endoplasmic reticulum, six potential sites for N-linked glycosylation and two potential adenosine 5'-triphosphate binding sites, similar to other mammalian and avian GRP94 homologues. In Northern blot hybridization using a cDNA probe from the bovine GRP94 cDNA sequence, a transcript 3.0 kb in size was detected. We measured the amounts of GRP94 and its mRNA in mammary glands from cows at various developmental stages of hormonally induced lactation. The highest level of GRP94 mRNA, determined by dot blot analysis, was detected in the developing stage. In contrast to the mRNA level, the amount of protein, determined by immunoblot analysis using rabbit antiserum raised against GRP94 purified from bovine brain, was higher in lactating stages than in others. The increased level of GRP94 mRNA during the developing stage and the maintenance of GRP94 protein during lactation suggest that the synthesis of GRP94 is regulated during mammary development and differentiation, and also that the protein is involved in a function related to lactation. (C) 2001 Elsevier Science Inc. All rights reserved.
Molecular cloning of bovine (Bos taurus) cDNA encoding a 94-kDa glucose-regulated protein and developmental changes in its mRNA and protein content in the mammary gland, A Watanabe, Uchida, I, K Nakata, Y Fujimoto, S Oikawa, COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 130, (4) 547 - 557,   2001年12月, 10.1016/S1096-4959(01)00464-X, We isolated and sequenced cDNA clones encoding a 94-kDa glucose-regulated protein (GRP94) from a cDNA library constructed using bovine (Bos taurus) mammary gland poly(A) I RNA. The coding nucleotide sequence and the deduced amino acid sequence of bovine GRP94 shared 94.2-88.4% and 98.1-96.5% identity with those of other mammalian species, respectively. The primary structure contained a carboxyl-terminal signal sequence for retention in the endoplasmic reticulum, six potential sites for N-linked glycosylation and two potential adenosine 5'-triphosphate binding sites, similar to other mammalian and avian GRP94 homologues. In Northern blot hybridization using a cDNA probe from the bovine GRP94 cDNA sequence, a transcript 3.0 kb in size was detected. We measured the amounts of GRP94 and its mRNA in mammary glands from cows at various developmental stages of hormonally induced lactation. The highest level of GRP94 mRNA, determined by dot blot analysis, was detected in the developing stage. In contrast to the mRNA level, the amount of protein, determined by immunoblot analysis using rabbit antiserum raised against GRP94 purified from bovine brain, was higher in lactating stages than in others. The increased level of GRP94 mRNA during the developing stage and the maintenance of GRP94 protein during lactation suggest that the synthesis of GRP94 is regulated during mammary development and differentiation, and also that the protein is involved in a function related to lactation. (C) 2001 Elsevier Science Inc. All rights reserved.
牛の脂肪肝、ケトーシス、第四胃変位、乳熱そして胎盤停滞における血清アポ蛋白C-(]G0003[)濃度の低下, 日本獣医学会誌, 63, (3) 227 - 231,   2001年, 10.1292/jvms.63.227
疾病に罹患した乳牛における肝臓・筋肉のグリコーゲンおよびトリグリセリド量の検討, 北海道獣医師会雑誌, 45,   2001年
Decreased Concentration of Serum Apolipoprotein C-(]G0003[) in Cows with Fatty liver, Ketosis, Left Displacement of the Abomasum, Milk Fever and Retained Placenta, The Journal of Veterinary Medical Science, 63, (3) 227 - 231,   2001年, 10.1292/jvms.63.227
乳牛における乳汁アンモニアおよび他の窒素成分濃度, 日本獣医師会雑誌, 53,   2000年, 10.12935/jvma1951.53.806
絶食牛における肝の脂肪化と体重および各種血清成分値との関連, 獣医生化学, 37,   2000年
乳牛の周産期疾病と脂肪肝との関連性 ~リポタンパク質関連の新たな検査マーカー~, プロダクションメデイスン研究フォーラム2000,   2000年
Serum apolipoprotein A-I evaluated as a possible marker in cows with Johne's disease., J. Rakuno Gakuen Univ., 25,   2000年
Serum apolipoprotein B-100 and A-I assessed in healthy cattle according to growth, lactation and gender., J. Rakuno Gakuen Univ., 25,   2000年
Increased serum concentration of apolipoprotein C-III and its greater distrlbution to chylomicrons than to the high-density lipoprotein fraction in a calf with hyperlipidemia., YAMAMOTO M, OOHASHI T, KATOH N, OIKAWA S, J.Vet.Med.Sci., 62, (10) 1033 - 1039,   2000年, 10.1292/jvms.62.1033
牛における伝染性異常産とその予防, 酪農ジャーナル, 5月号 p32-35,   2000年
Serum apolipoprotein A-I evaluated as a possible marker in cows with Johne's disease., J. Rakuno Gakuen Univ., 25,   2000年
Serum apolipoprotein B-100 and A-I assessed in healthy cattle according to growth, lactation and gender., J. Rakuno Gakuen Univ., 25,   2000年
Increased serum concentration of apolipoprotein C-III and its greater distrlbution to chylomicrons than to the high-density lipoprotein fraction in a calf with hyperlipidemia., J.Vet.Med.Sci., 62, (10) 1033 - 1039,   2000年, 10.1292/jvms.62.1033
血清アポリポタンパク質B-100とA-I濃度のケトーシスおよび第四胃左方変位牛における診断的意義, 北海道獣医師会雑誌, 43,   1999年
放牧育成牛における消化管内線虫の駆虫効果, 酪農ジャーナル, 3月号 p-36-38,   1999年
Evaluation of serum apolipoprotein C-III concentration by enzyme-linked immunosorbent assay and its higher concentration in cows during micllactation than during the nonlactating satage., Am.J.Vet.Res, 59,   1998年
乳牛における牛乳クエン酸濃度および乳成分との関係, 日本畜産学会報, 69,   1998年, 10.2508/chikusan.69.381
Identification and purificatlon of apolipoprotein C-III from the serum of cows., Am.J.Vet.Res., 59,   1998年
放牧育成牛の消化管内線虫に対するイベルメクチン製剤の効果, 日本獣医師会雑誌, 51,   1998年, 10.12935/jvma1951.51.237
Evaluation of serum apolipoprotein C-III concentration by enzyme-linked immunosorbent assay and its higher concentration in cows during micllactation than during the nonlactating satage., Am.J.Vet.Res., 59,   1998年
Identification and purificatlon of apolipoprotein C-III from the serum of cows., Am.J.Vet.Res., 59,   1998年
Reduced concentrations of apolipoproteins B-100 and A-I in serum from cows with retained placenta, S Oikawa, N Katoh, CANADIAN JOURNAL OF VETERINARY RESEARCH-REVUE CANADIENNE DE RECHERCHE VETERINAIRE, 61, (4) 312 - 314,   1997年10月, The purpose of the present study was to evaluate apolipoprotein B-100 and A-I concentrations in cows with retained placenta. Animals used were cows with retained placenta alone (it 10), those with both retained placenta and ketosis (n = 7), and controls (n 10). Apolipoprotein B-100 concentrations at 2 to 4 d after parturition were significantly (P < 0.01) decreased in cows with retained placenta alone (mean +/- SD, 0.083 +/- 0.029 mg/mL of serum) when compared with those in control cows (0.154 +/- 0.022 mg/mL). Apolipoprotein A-I concentrations (0.713 +/- 0.177 mg/mL) were also significantly (P < 0.05) lower than those of controls (0.895 +/- 0.159 mg/mL). The decreases were more distinct for apolipoproteins B-100 (55% of controls) than A-I concentrations (80% of controls). Concentrations of apolipoprotein B-100 (0.071 +/- 0.032 mg/mL; P < 0.01) and A-I (0.708 +/- 0.189 mg/mL; P < 0.05) in the cows with both retained placenta and ketosis were also reduced, when compared with values in controls. Other than apolipoproteins, cows with retained placenta alone had significantly (P < 0.01) higher serum nonesterified fatty acids, and lower triglyceride concentrations. Significantly (P < 0.01) higher nonesterified fatty acids and lower triglyceride concentrations were similarly observed in cows with both retained placenta and ketosis.
Reduced concentrations of apolipoproteins B-100 and A-I in serum from cows with retained placenta, S Oikawa, N Katoh, CANADIAN JOURNAL OF VETERINARY RESEARCH-REVUE CANADIENNE DE RECHERCHE VETERINAIRE, 61, (4) 312 - 314,   1997年10月, The purpose of the present study was to evaluate apolipoprotein B-100 and A-I concentrations in cows with retained placenta. Animals used were cows with retained placenta alone (it 10), those with both retained placenta and ketosis (n = 7), and controls (n 10). Apolipoprotein B-100 concentrations at 2 to 4 d after parturition were significantly (P < 0.01) decreased in cows with retained placenta alone (mean +/- SD, 0.083 +/- 0.029 mg/mL of serum) when compared with those in control cows (0.154 +/- 0.022 mg/mL). Apolipoprotein A-I concentrations (0.713 +/- 0.177 mg/mL) were also significantly (P < 0.05) lower than those of controls (0.895 +/- 0.159 mg/mL). The decreases were more distinct for apolipoproteins B-100 (55% of controls) than A-I concentrations (80% of controls). Concentrations of apolipoprotein B-100 (0.071 +/- 0.032 mg/mL; P < 0.01) and A-I (0.708 +/- 0.189 mg/mL; P < 0.05) in the cows with both retained placenta and ketosis were also reduced, when compared with values in controls. Other than apolipoproteins, cows with retained placenta alone had significantly (P < 0.01) higher serum nonesterified fatty acids, and lower triglyceride concentrations. Significantly (P < 0.01) higher nonesterified fatty acids and lower triglyceride concentrations were similarly observed in cows with both retained placenta and ketosis.
Decreased serum apolipoprotein A-I concentrations in cows infected with Salmonella Typhimurium, S Oikawa, N Katoh, H Itoh, T Miyamoto, M Konno, T Kajita, CANADIAN JOURNAL OF VETERINARY RESEARCH-REVUE CANADIENNE DE RECHERCHE VETERINAIRE, 61, (3) 182 - 186,   1997年07月, Serum apolipoprotein A-I concentrations in cows infected with Salmonella Typhimurium were evaluated to assess its relevance in salmonellosis. Apolipoprotein A-I has been shown in rats to be secreted by the intestine as well as the liver. Clinical symptoms such as diarrhea revealed an outbreak of salmonellosis in 22 cows on a farm, and sera were obtained at 6 (acute phase), 16, 28 (convalescent period) and 42 d (postconvalescent period) after the outbreak. Apolipoprotein A-I concentrations (mean +/- SD, mg/mL), determined by ELISA, were 0.598 +/- 0.497 (day 6), 0.111 +/- 0.060 (day 16), 0.432 +/- 0.311 (day 28) and 0.727 +/- 0.516 (day 42), Compared with the concentration at day 42, those at 16 and 28 d were significantly (P < 0.01, P < 0.05) lower, but that at day 6 was not. The serum concentration of apolipoprotein B-100 (of liver origin in cattle) was unaltered during the course of salmonellosis. The concentration of apolipoprotein A-I was positively correlated with those of serum total cholesterol (r = 0.589, P < 0.01) and phospholipids (r = 0.590, P < 0.01). These results suggest that apolipoprotein A-I in cattle is in part of intestinal origin, and also that its decreased serum concentration in salmonellosis can be attributed to the reduced intestinal synthesis or secretion of this apolipoprotein. Moreover, as a potential carrier for dietary lipids such as cholesterol, determination of serum apolipoprotein A-I concentration is suggested to be useful when assessing the nutritional status of the affected cows.
Decreased serum apolipoprotein A-I concentrations in cows infected with Salmonella Typhimurium, S Oikawa, N Katoh, H Itoh, T Miyamoto, M Konno, T Kajita, CANADIAN JOURNAL OF VETERINARY RESEARCH-REVUE CANADIENNE DE RECHERCHE VETERINAIRE, 61, (3) 182 - 186,   1997年07月, Serum apolipoprotein A-I concentrations in cows infected with Salmonella Typhimurium were evaluated to assess its relevance in salmonellosis. Apolipoprotein A-I has been shown in rats to be secreted by the intestine as well as the liver. Clinical symptoms such as diarrhea revealed an outbreak of salmonellosis in 22 cows on a farm, and sera were obtained at 6 (acute phase), 16, 28 (convalescent period) and 42 d (postconvalescent period) after the outbreak. Apolipoprotein A-I concentrations (mean +/- SD, mg/mL), determined by ELISA, were 0.598 +/- 0.497 (day 6), 0.111 +/- 0.060 (day 16), 0.432 +/- 0.311 (day 28) and 0.727 +/- 0.516 (day 42), Compared with the concentration at day 42, those at 16 and 28 d were significantly (P < 0.01, P < 0.05) lower, but that at day 6 was not. The serum concentration of apolipoprotein B-100 (of liver origin in cattle) was unaltered during the course of salmonellosis. The concentration of apolipoprotein A-I was positively correlated with those of serum total cholesterol (r = 0.589, P < 0.01) and phospholipids (r = 0.590, P < 0.01). These results suggest that apolipoprotein A-I in cattle is in part of intestinal origin, and also that its decreased serum concentration in salmonellosis can be attributed to the reduced intestinal synthesis or secretion of this apolipoprotein. Moreover, as a potential carrier for dietary lipids such as cholesterol, determination of serum apolipoprotein A-I concentration is suggested to be useful when assessing the nutritional status of the affected cows.
Detection of serum haptoglobin by enzyme-linked immunosorbent assay in cows with fatty liver, H Nakagawa, O Yamamoto, S Oikawa, H Higuchi, A Watanabe, N Katoh, RESEARCH IN VETERINARY SCIENCE, 62, (2) 137 - 141,   1997年03月, Haptoglobin cannot be detected in the serum of healthy cattle by the haemoglobin-binding assay or single radial immunodiffusion. The present study was designed to examine whether an enzyme-linked immunosorbent assay could be applied to measure serum haptoglobin concentrations in healthy cows and in cows with fatty liver. When either purified cow haptoglobin or haptoglobin-positive serum were used as the antigen in the assay, the standard curves obtained were distinctly different, and haptoglobin in serum was detected more sensitively than the purified protein. The addition of bovine serum albumin to purified haptoglobin shifted the curve towards that obtained with haptoglobin-positive serum, suggesting that an interaction with serum albumin was partly responsible for the different standard curves. By use of the standard curve for haptoglobin in serum, the mean (SEM) concentration of haptoglobin in samples from four cows with fatty liver was 466 (147) mu g ml(-1), but the sera from four apparently healthy cows contained less than 0.01 mu g ml(-1) haptoglobin.
Detection of serum haptoglobin by enzyme-linked immunosorbent assay in cows with fatty liver, H Nakagawa, O Yamamoto, S Oikawa, H Higuchi, A Watanabe, N Katoh, RESEARCH IN VETERINARY SCIENCE, 62, (2) 137 - 141,   1997年03月, Haptoglobin cannot be detected in the serum of healthy cattle by the haemoglobin-binding assay or single radial immunodiffusion. The present study was designed to examine whether an enzyme-linked immunosorbent assay could be applied to measure serum haptoglobin concentrations in healthy cows and in cows with fatty liver. When either purified cow haptoglobin or haptoglobin-positive serum were used as the antigen in the assay, the standard curves obtained were distinctly different, and haptoglobin in serum was detected more sensitively than the purified protein. The addition of bovine serum albumin to purified haptoglobin shifted the curve towards that obtained with haptoglobin-positive serum, suggesting that an interaction with serum albumin was partly responsible for the different standard curves. By use of the standard curve for haptoglobin in serum, the mean (SEM) concentration of haptoglobin in samples from four cows with fatty liver was 466 (147) mu g ml(-1), but the sera from four apparently healthy cows contained less than 0.01 mu g ml(-1) haptoglobin.
Synthesis and messenger ribonucleic acid expression of apolipoproteins E and A-I by the bovine corpus luteum during the estrous cycle and pregnancy, FM NdikumMoffor, RCM Simmen, PA Fields, N Katoh, S Oikawa, WC Buhi, MK Rollyson, SMT Chang, MJ Fields, BIOLOGY OF REPRODUCTION, 56, (3) 745 - 756,   1997年03月, 10.1095/biolreprod56.3.745, In an attempt to characterize proteins secreted by the corpus luteum, explant cultures of luteal slices from cows taken on Days 3, 7, 11, 14, 17, and 19 of the estrous cycle, and Days 17, 88, 180, and > 240 of pregnancy were incubated with H-3-leucine for 24 h. Proteins in luteal-conditioned medium were separated by two-dimensional PAGE, transferred to polyvinylidene fluoride membrane, and subjected to N-terminal amino acid microsequencing. Microsequence analysis revealed that the bovine corpus luteum synthesized and released de novo synthesized apolipoproteins (Apo) E and A-I in culture during the estrous cycle and pregnancy. Release of Apo E was observed only on Day 3 of the estrous cycle. Release of Apo A-I was observed on Days 11, 14, 17, and 19 of the estrous cycle, and on all days of pregnancy examined. To demonstrate the presence of the appropriate mRNA and characterize the temporal relationship for these identified proteins, total RNA was isolated from corpora lutea on Days 2, 3, 7, 16, 17, and 20 of the estrous cycle, and on Days 17, 90, 170, 180, and 272 of pregnancy, and submitted to Northern and dot blot analysis. Apo E mRNA was expressed only on Days 2-3 of the estrous cycle and was not expressed on the other days of the cycle or during pregnancy. A single Apo E mRNA transcript about 1.0 kilobase (kb) in size was observed. Expression of Apo A-I mRNA was detected on all days of the estrous cycle and pregnancy examined. Apo A-I cDNA hybridized with a single mRNA transcript about 1.0 kb in size. Apo A-I mRNA levels did not differ among days of the estrous cycle, although higher levels of Apo A-I mRNA were observed during later stages of pregnancy. Serum concentrations of Apo A-I and progesterone were correlated across the estrous cycle but not during the prepartum period or after parturition. This study demonstrates for the first time that the corpus luteum synthesizes Apo E and Apo A-I and expresses their respective mRNAs. The pattern of expression of Apo E and Apo A-I mRNAs paralleled that of de novo synthesis of their respective proteins after incubation of luteal tissue with [H-3]leucine. The role of luteal apolipoproteins may involve an autocrine/paracrine function influencing luteal development, tissue remodeling, and steroidogenesis.
Decreased serum apolipoprotein B-100 and A-I concentrations in cows with ketosis and left displacement of the abomasum, S Oikawa, N Katoh, F Kawawa, Y Ono, AMERICAN JOURNAL OF VETERINARY RESEARCH, 58, (2) 121 - 125,   1997年02月, Objective-To assess the relevance of hepatic lipidosis (fatty liver) in the development of ketosis and left displacement of the abomasum (LDA). Sample Population-Sera from 22 healthy cows in early lactation, 21 cows with ketosis, and 19 cows with LDA, and serum and liver specimens from 35 slaughtered cows with or without fatty liver, ketosis, and/or LDA. Procedure-Apolipoprotein B-100 and A-l concentrations were measured in sera of healthy farm cows and of farm cows with ketosis and LDA. Serum apolipoprotein concentration, together with liver triglyceride content, also were surveyed in a subset of slaughtered cows. Results-Compared with those in healthy cows or controls, apolipoprotein B-100 and A-l concentrations were decreased in cows with ketosis and LDA. Conclusions-Decreases in apolipoprotein B-100 and A-l concentrations in cows with ketosis and LDA indicate that the 2 disorders may be intimately associated with fatty liver. Clinical Relevance-Monitoring of the apolipoprotein B-100 and A-l concentrations during the stages of nonlactation and early lactation is helpful for detecting cows susceptible to ketosis and IDA.
Immunohistochemical localization of α1-acld glvcoprotein in liver tissues of bovine fetuses, newborn calves, and sick or healthy adult cattle., Am.J.Vet.Res., 58,   1997年
オーサリングソフトを活用した家畜衛生情報のライブラリー化の検討, 岩手県獣医師会報, 23,   1997年
ウシ黄体での性周期と妊娠期間におけるアポ蛋白EとA-Iのm-RNAの発現と合成, 繁殖の生物学, 56,   1997年
ケトーシスおよび第四胃変位牛における血清アポ蛋白B-100とA-I濃度の低下, アメリカ獣医学会誌, 58, (2) 121 - 125,   1997年
Decreased serum lecithin:cholesterol acyltransferase activity in spontaneous cases of fatty liver in cows, H Nakagawa, S Oikawa, T Oohashi, N Katoh, VETERINARY RESEARCH COMMUNICATIONS, 21, (1) 1 - 8,   1997年01月, Lecithin:cholesterol acyltransferase (LCAT) activity in serum was evaluated in spontaneous cases of fatty liver in cows. The enzyme activity of 631 +/- 62 U (mean +/- SEM, decrease in nmol of free cholesterol per h per ml of serum) in cows with fatty liver (n = 16) was significantly (p<0.01) lower than that in cows without fatty liver (979 +/- 22 U; n = 16). In addition to the decrease in LCAT activity, the concentrations of phosphatidylcholine (a fatty aryl donor for esterification of free cholesterol) and of cholesteryl esters (products of the LCAT reaction) were reduced in the high-density lipoprotein fractions from cows with fatty livers. The concentration in the serum of apolipoprotein A-I, an activator of LCAT, was also reduced in cows with Fatty livers. These results suggest that the decreased LCAT activity, which may be attributable to impaired hepatic secretion or to the suppression of the activity in the plasma by reduced concentrations of phosphatidylcholine and apolipoprotein A-I, resulted in the lower concentrations of cholesteryl esters. Because cholesteryl esters are utilized in steroidogenic tissues for the synthesis of steroid hormones such as progesterone and glucocorticoids, an insufficient supply of the cholesterols may be of relevance to the reduced fertility and immune competence observed in cows with fatty livers.
Immunohistochemical localization of α1-acld glvcoprotein in liver tissues of bovine fetuses, newborn calves, and sick or healthy adult cattle., Am.J.Vet.Res., 58,   1997年
Decreased serum lecithin:cholesterol acyltransferase activity in spontaneous cases of fatty liver in cows, H Nakagawa, S Oikawa, T Oohashi, N Katoh, VETERINARY RESEARCH COMMUNICATIONS, 21, (1) 1 - 8,   1997年01月, Lecithin:cholesterol acyltransferase (LCAT) activity in serum was evaluated in spontaneous cases of fatty liver in cows. The enzyme activity of 631 +/- 62 U (mean +/- SEM, decrease in nmol of free cholesterol per h per ml of serum) in cows with fatty liver (n = 16) was significantly (p<0.01) lower than that in cows without fatty liver (979 +/- 22 U; n = 16). In addition to the decrease in LCAT activity, the concentrations of phosphatidylcholine (a fatty aryl donor for esterification of free cholesterol) and of cholesteryl esters (products of the LCAT reaction) were reduced in the high-density lipoprotein fractions from cows with fatty livers. The concentration in the serum of apolipoprotein A-I, an activator of LCAT, was also reduced in cows with Fatty livers. These results suggest that the decreased LCAT activity, which may be attributable to impaired hepatic secretion or to the suppression of the activity in the plasma by reduced concentrations of phosphatidylcholine and apolipoprotein A-I, resulted in the lower concentrations of cholesteryl esters. Because cholesteryl esters are utilized in steroidogenic tissues for the synthesis of steroid hormones such as progesterone and glucocorticoids, an insufficient supply of the cholesterols may be of relevance to the reduced fertility and immune competence observed in cows with fatty livers.
乳牛のケトーシスおよび第四胃変位における血清アポ蛋白質B-100とA-Iの低下の意義, 岩手県家畜衛生年報(平成7年度),   1996年
牛血清アポ蛋白A-Iの測定値とその臨床的意義, 岩手県家畜衛生年報(平成6年度),   1995年
虚弱子牛における血清生化学検査値とそのリンパ球幼弱化反応, 岩手県家畜衛生年報(平成6年度),   1995年
Enzyme-linked immunosorbent assay for serum apolipoprotein B-100,a major triglyceride-transport protein in dairy cows., Am.J.Vet.Res., 56,   1995年
Enzyme-linked immunosorbent assay for apolipoprotein A-I in the serum of cattle., Am.J.Vet.Res., 56,   1995年
Enzyme-linked immunosorbent assay for serum apolipoprotein B-100,a major triglyceride-transport protein in dairy cows., Am.J.Vet.Res., 56,   1995年
Enzyme-linked immunosorbent assay for apolipoprotein A-I in the serum of cattle., Am.J.Vet.Res., 56,   1995年
牛血清アポリポタンパク質A-IおよびB-100のELISAによる測定, 家畜生化学, 31,   1994年
乳牛の分娩前後における乳汁中の体細胞数と生菌数の動態, 岩手県獣医師会報, 20,   1994年
ブロイラーにおける胸部嚢疱の発生要因と防除対策, 鶏病研究会報, 29,   1993年
撹拌の違いによる成分的乳質について, 岩手県家畜衛生年報(平成元年度),   1990年
新しい細菌数格差制度に対応した乳質改善指導体制の確立-北生検式ブリード法の応用-, 岩手県家畜衛生年報(昭和63年度),   1989年
乳房炎防除対策とその改善効果, 岩手県家畜衛生年報(昭和62年度),   1988年
COMPOUND 48/80 ELICITS CHOLINERGIC CONTRACTION THROUGH HISTAMINE-RELEASE IN THE CHICK ESOPHAGUS, T TANEIKE, H MIYAZAKI, S OIKAWA, A OHGA, GENERAL PHARMACOLOGY, 19, (5) 689 - 695,   1988年, 10.1016/0306-3623(88)90130-9
COMPOUND 48/80 ELICITS CHOLINERGIC CONTRACTION THROUGH HISTAMINE-RELEASE IN THE CHICK ESOPHAGUS, T TANEIKE, H MIYAZAKI, S OIKAWA, A OHGA, GENERAL PHARMACOLOGY, 19, (5) 689 - 695,   1988年, 10.1016/0306-3623(88)90130-9

受賞

  2018年11月, 日本家畜臨床学会, 日本家畜臨床学会長賞, 泌乳初期の潜在性ケトーシス牛に対する塩酸ベタイン製剤の投与効果

競争的資金

文部省科学研究費, 乳牛群の潜在性2型ケトーシスに対する実践的早期対策と臨床獣医師の予防意識調査
文部省科学研究費, 乳牛群における潜在性2型ケトーシスの発生実態とリスク要因の解明
文部省科学研究費, ウシの脂肪肝の脂肪肝におけるアポトーシスに関する基礎的研究
文部省科学研究費, ウシの脂肪肝の発生機序に関する基礎的研究
伊藤記念財団, 放牧育成牛における胃腸障害の検査マーカーとしての血清ペプシノーゲンとアポリポタンパク質A-Iの評価
文部省科学研究費, ウシの脂肪肝におけるインスリン抵抗性とTNFαとの関連性に関する基礎的研究
フロンティア研究, 牛および馬の脂質代謝に関する研究
秋山記念生命科学振興財団研究助成, ウシの脂肪肝における熱ショックタンパク質の発現に関する基礎的研究
Prevention and Control of Metabolic Diseases in Dairy Cattle
The Epidemiological Evaluation of Periparturient Diseases in Cows and Their Preventions
Frontier Research, Study on Lipid Metabolism in Cows and Horses


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