獣医学群・獣医保健看護学類
教員 北澤多喜雄 キタザワ タキオ
メールアドレス:
ホームページ:

更新日 :2017/08/22

研究者基本情報

氏名

北澤多喜雄
キタザワ タキオ

所属(マスタ)

獣医学群・獣医保健看護学類, 教員

所属・職名

獣医学群
教授

学歴

1979年04月 - 1981年03月, 北海道大学大学院, 獣医学研究科, 形態機能学専攻修士課程
1975年04月 - 1979年03月, 北海道大学, 獣医学部
1972年04月 - 1975年03月, 長野県立上田高等学校

学位

獣医学博士, 北海道大学

所属学協会

日本動物看護学会
日本平滑筋学会
日本薬理学会
日本獣医学会

研究活動情報

研究分野

基礎生物学, 形態・構造
動物生命科学, 獣医学, 比較動物薬理学

研究キーワード

ムスカリン受容体,
モチリン、グレリン,
比較生物学,
消化管ホルモン,
自律神経,
消化管運動,
薬理学,

論文

The chicken is an interesting animal for study of the functional role of ghrelin in the gastrointestinal tract, 北澤多喜雄, Endocrine Journal, 64, S5 - S9,   2017年07月
Neuropeptide Y (NPY) inhibits spontaneous contraction of the mouse atrium by possible activation of the NPY1 receptor, Oki Y, Teraoka H, Kitazawa T, Autonomic Autacoid Pharmacology, 37, 23 - 28,   2017年06月, 査読有り
Does motilin peptide regulate gastrointestinal motility of zebrafish? An in vitro study using isolated intestinal strips., Kitazawa T, Yoshida M, Teraoka H, Kaiya H, General and comparative endocrinology, 249, 15 - 23,   2017年08月, 査読有り
Characterization of feline cytochrome P450 2B6., Okamatsu G, Komatsu T, Ono Y, Inoue H, Uchide T, Onaga T, Endoh D, Kitazawa T, Hiraga T, Uno Y, Teraoka H, Xenobiotica; the fate of foreign compounds in biological systems, 47, (2) 93 - 102,   2017年02月, 査読有り
Functional expression and comparative characterization of four feline P450 cytochromes using fluorescent substrates., Okamatsu G, Kawakami K, Komatsu T, Kitazawa T, Uno Y, Teraoka H, Xenobiotica; the fate of foreign compounds in biological systems, 1 - 11,   2016年11月, 査読有り
Pharmacological characterization of muscarinic receptor subtypes involved in carbachol-induced contraction of the chicken proventriculus, Kitazawa Takio、Nahoko Kondo, Tetsuro Taneike, 2, (1) 1003 - 1012,   2016年10月, 査読有り
Protective effect of prostacyclin against pre-cardiac edema caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin and a thromboxane receptor agonist in developing zebrafish., Nijoukubo D, Tanaka Y, Okuno Y, Yin G, Kitazawa T, Peterson RE, Kubota A, Teraoka H, Chemosphere, 156, 111 - 117,   2016年08月, 査読有り
Molecular cloning of motilin and mechanism of motilin-induced gastrointestinal motility in Japanese quail., Apu AS, Mondal A, Kitazawa T, Takemi S, Sakai T, Sakata I, General and comparative endocrinology, 233, 53 - 62,   2016年07月, 査読有り
Effects of ghrelin and motilin on smooth muscle contractility of the isolated gastrointestinal tract from the bullfrog and Japanese fire belly newt., Kitazawa T, Shimazaki M, Kikuta A, Yaosaka N, Teraoka H, Kaiya H, General and comparative endocrinology, 232, 51 - 59,   2016年06月, 査読有り
Accumulation properties of inorganic mercury and organic mercury in the red-crowned crane Grus japonensis in east Hokkaido, Japan., Teraoka H, Okamoto E, Kudo M, Nakayama SM, Ikenaka Y, Ishizuka M, Endo T, Kitazawa T, Hiraga T, Ecotoxicology and environmental safety, 122, 557 - 564,   2015年12月, 査読有り
Correlation of ghrelin concentration and ghrelin, ghrelin-O-acetyltransferase (GOAT) and growth hormone secretagogue receptor 1a mRNAs expression in the proventriculus and brain of the growing chicken., Kitazawa T, Hiraga T, Teraoka H, Yaosaka N, Kaiya H, Peptides, 63, 134 - 142,   2015年01月, 査読有り
Identification and functional characterization of novel feline cytochrome P450 2A., Okamatsu G, Komatsu T, Kubota A, Onaga T, Uchide T, Endo D, Kirisawa R, Yin G, Inoue H, Kitazawa T, Uno Y, Teraoka H, Xenobiotica; the fate of foreign compounds in biological systems, 45, (6) 503 - 510,   2015年, 査読有り
Involvement of COX2-thromboxane pathway in TCDD-induced precardiac edema in developing zebrafish., Teraoka H, Okuno Y, Nijoukubo D, Yamakoshi A, Peterson RE, Stegeman JJ, Kitazawa T, Hiraga T, Kubota A, Aquatic toxicology (Amsterdam, Netherlands), 154, 19 - 26,   2014年09月, 査読有り
Age-dependent reduction of ghrelin- and motilin-induced contractile activity in the chicken gastrointestinal tract., Kitazawa T, Yoshida A, Tamano T, Teraoka H, Kaiya H, Peptides, 43, 88 - 95,   2013年05月, 査読有り
A ganglionic stimulant, 1,1-dimethyl-4-phenylpiperazinium, caused both cholinergic and adrenergic responses in the isolated mouse atrium., Ochi K, Teraoka H, Unno T, Komori S, Yamada M, Kitazawa T, European journal of pharmacology, 704, (1-3) 7 - 14,   2013年03月, 査読有り
Large-scale survey of mitochondrial D-loop of the red-crowned crane Grus japonensis in Hokkaido, Japan by convenient genotyping method., Miura Y, Shiomi A, Shiraishi J, Makita K, Asakawa M, Kitazawa T, Hiraga T, Momose Y, Momose K, Masatomi H, Teraoka H, The Journal of veterinary medical science, 75, (1) 43 - 47,   2013年01月, 査読有り
Origin of three Red-crowned Cranes Grus japonensis found in northeast Honshu and west Hokkaido, Japan, from 2008 to 2012., Miura Y, Shiraishi J, Shiomi A, Kitazawa T, Hiraga T, Matsumoto F, Teraoka H, Masatomi H, The Journal of veterinary medical science, 75, (9) 1241 - 1244,   2013年, 査読有り
Evidence for M2 and M3 muscarinic receptor involvement in cholinergic excitatory junction potentials through synergistic activation of cation channels in the longitudinal muscle of mouse ileum., Matsuyama H, Tanahashi Y, Kitazawa T, Yamada M, Komori S, Unno T, Journal of pharmacological sciences, 121, (3) 227 - 236,   2013年, 査読有り
Ghrelin does not affect gastrointestinal contractility in rainbow trout and goldfish in vitro., Kitazawa T, Itoh K, Yaosaka N, Maruyama K, Matsuda K, Teraoka H, Kaiya H, General and comparative endocrinology, 178, (3) 539 - 545,   2012年09月, 査読有り
Changes of mercury contamination in red-crowned cranes, Grus japonensis, in East Hokkaido, Japan., Teraoka H, Tagami Y, Kudo M, Miura Y, Okamoto E, Matsumoto F, Koga K, Uebayashi A, Shimura R, Inoue M, Momose K, Masatomi H, Kitazawa T, Hiraga T, Subramanian A, Archives of environmental contamination and toxicology, 63, (1) 153 - 160,   2012年07月, 査読有り
Differential display system with vertebrate-common degenerate oligonucleotide primers: uncovering genes responsive to dioxin in avian embryonic liver., Teraoka H, Ito S, Ikeda H, Kubota A, Abou Elmagd MM, Kitazawa T, Kim EY, Iwata H, Endoh D, Environmental science & technology, 46, (1) 27 - 33,   2012年01月, 査読有り
Muscarinic receptor subtypes involved in regulation of colonic motility in mice: functional studies using muscarinic receptor-deficient mice., Kondo T, Nakajima M, Teraoka H, Unno T, Komori S, Yamada M, Kitazawa T, European journal of pharmacology, 670, (1) 236 - 243,   2011年11月, 査読有り
Expression of two novel cytochrome P450 3A131 and 3A132 in liver and small intestine of domestic cats., Honda K, Komatsu T, Koyama F, Kubota A, Kawakami K, Asakura H, Uno Y, Kitazawa T, Hiraga T, Teraoka H, The Journal of veterinary medical science, 73, (11) 1489 - 1492,   2011年11月, 査読有り
Molecular identification of ghrelin receptor (GHS-R1a) and its functional role in the gastrointestinal tract of the guinea-pig., Kitazawa T, Nakamura T, Saeki A, Teraoka H, Hiraga T, Kaiya H, Peptides, 32, (9) 1876 - 1886,   2011年09月, 査読有り
Molecular cloning and expression of cytochrome P450 2D6 in the livers of domestic cats., Komatsu T, Honda K, Kubota A, Kitazawa T, Hiraga T, Teraoka H, The Journal of veterinary medical science, 72, (12) 1633 - 1636,   2010年12月, 査読有り
Muscarinic receptor subtypes mediating Ca2+ sensitization of intestinal smooth muscle contraction: studies with receptor knockout mice., Suguro M, Matsuyama H, Tanahashi Y, Unno T, Kitazawa T, Yamada M, Komori S, The Journal of veterinary medical science, 72, (4) 443 - 451,   2010年04月, 査読有り
Molecular cloning of growth hormone secretagogue-receptor and effect of quail ghrelin on gastrointestinal motility in Japanese quail., Kitazawa T, Maeda Y, Kaiya H, Regulatory peptides, 158, (1-3) 132 - 142,   2009年11月, 査読有り
M3 muscarinic receptors mediate positive inotropic responses in mouse atria: a study with muscarinic receptor knockout mice., Kitazawa T, Asakawa K, Nakamura T, Teraoka H, Unno T, Komori S, Yamada M, Wess J, The Journal of pharmacology and experimental therapeutics, 330, (2) 487 - 493,   2009年08月, 査読有り
Excitatory and inhibitory 5-hydroxytryptamine (5-HT) receptors expressed in the isolated porcine uterine muscles., Nakamura T, Kitazawa T, Cao J, Iwamoto T, Teraoka H, Kadota K, Taneike T, European journal of pharmacology, 600, (1-3) 123 - 129,   2008年12月, 査読有り
A non-selective cationic channel activated by diacylglycerol in mouse intestinal myocytes., Sakamoto T, Matsuyama H, Yamamoto M, Tanahashi Y, Kitazawa T, Taneike T, Komori S, Unno T, European journal of pharmacology, 599, (1-3) 54 - 57,   2008年12月, 査読有り
Characterization of prostanoid receptors present on adrenergic neurons innervating the porcine uterine longitudinal muscle., Cao J, Nakamura T, Kitazawa T, Yamashiki N, Yamamoto T, Taneike T, Prostaglandins & other lipid mediators, 86, (1-4) 26 - 34,   2008年06月, 査読有り
Muscarinic receptor subtypes involved in carbachol-induced contraction of mouse uterine smooth muscle., Kitazawa T, Hirama R, Masunaga K, Nakamura T, Asakawa K, Cao J, Teraoka H, Unno T, Komori S, Yamada M, Wess J, Taneike T, Naunyn-Schmiedeberg's archives of pharmacology, 377, (4-6) 503 - 513,   2008年06月, 査読有り
Three distinct muscarinic signalling pathways for cationic channel activation in mouse gut smooth muscle cells., Sakamoto T, Unno T, Kitazawa T, Taneike T, Yamada M, Wess J, Nishimura M, Komori S, The Journal of physiology, 582, (Pt 1) 41 - 61,   2007年07月, 査読有り
Contractile effects of ghrelin-related peptides on the chicken gastrointestinal tract in vitro., Kitazawa T, Kaiya H, Taneike T, Peptides, 28, (3) 617 - 624,   2007年03月, 査読有り
Functional roles of muscarinic M2 and M3 receptors in mouse stomach motility: studies with muscarinic receptor knockout mice., Kitazawa T, Hashiba K, Cao J, Unno T, Komori S, Yamada M, Wess J, Taneike T, European journal of pharmacology, 554, (2-3) 212 - 222,   2007年01月, 査読有り
Endogenous prostaglandins regulate spontaneous contractile activity of uterine strips isolated from non-pregnant pigs., Cao J, Kitazawa T, Takehana K, Taneike T, Prostaglandins & other lipid mediators, 81, (3-4) 93 - 105,   2006年12月, 査読有り
Uterine region-dependent differences in responsiveness to prostaglandins in the non-pregnant porcine myometrium., Cao J, Yosida M, Kitazawa T, Taneike T, Prostaglandins & other lipid mediators, 75, (1-4) 105 - 122,   2005年01月, 査読有り
Gastric motor effects of peptide and non-peptide ghrelin agonists in mice in vivo and in vitro., Kitazawa T, De Smet B, Verbeke, K., Depoortere I. and Peeters T., Gut, 54, (8) 1078 - 1084,   2005年, 査読有り
Intracerebroventricular administration of chicken motilin does not induce hyperphagia in meat-type chicks., Bungo T, Ueda H, Kitazawa T, Taneike T, Furuse M, Physiology & behavior, 82, (2-3) 199 - 203,   2004年09月, 査読有り
Thromboxane A2 (TP) receptor in the non-pregnant porcine myometrium and its role in regulation of spontaneous contractile activity., Cao J, Wakatsuki A, Yoshida M, Kitazawa T, Taneike T, European journal of pharmacology, 485, (1-3) 317 - 327,   2004年02月, 査読有り
Pregnancy-associated changes in responsiveness of the porcine myometrium to bioactive substances., Kitazawa T, Hatakeyama H, Cao J, Taneike T, European journal of pharmacology, 469, (1-3) 135 - 144,   2003年05月, 査読有り
5-HT7 receptor-mediated relaxation of the oviduct in nonpregnant proestrus pigs., Inoue M, Kitazawa T, Cao J, Taneike T, European journal of pharmacology, 461, (2-3) 207 - 218,   2003年02月, 査読有り
In vitro pharmacological characterization of the prostanoid receptor population in the non-pregnant porcine myometrium., Cao J, Shayibuzhati M, Tajima T, Kitazawa T, Taneike T, European journal of pharmacology, 442, (1-2) 115 - 123,   2002年05月, 査読有り
Muscle layer- and region-dependent distributions of oxytocin receptors in the porcine myometrium., Peptides, 22, 963 - 974,   2001年, 査読有り
The mechanisms of α2-adrenoceptor agonist-induced contraction in longitudinal muscle of the porcine uterus., Kitazawa, T., Maezono, Y. and Taneike, T., European Journal Pharmacology, 390, 185 - 195,   2000年, 査読有り
Characterization of functional endothelin receptors in the porcine myometrium. , Isaka M., Takaoka K., Yamada Y., Abe Y., Kitazawa T. and Taneike T., Peptides, 21, 543 - 551,   2000年, 査読有り
Change of the involvement of 5-HT3 receptor in the gastric motor stimulating actions of KW-5139 (Leu13-motilin acetate) in the recovered and post-operative periods in dogs., Life Sciences, 67, (19) 2281 - 2292,   2000年, 査読有り
Smooth muscle layer-dependent distribution of 5-HT7 receptor in the porcine myometrium., Kitazawa T, Yamada Y, Iwano H, Yokota H, Yuasa A. and Taneike T., British Journal Pharmacology, 133, 79 - 89,   2000年, 査読有り
Smooth musle layer-specific variations in the autonomic innervation of bovine myometrium., Taneike, T., Kitazawa,T., Funakura,H., Asanuma, K., Tsuji, S., Yamada, M., Teraoka, H. and Ohga,, General Pharmacology, 32, 91 - 100,   1999年, 査読有り
Characterization of the muscarinic receptor subtype that mediates the contractile response of acetylcholine in the swine myometrium., Kitazawa, T., Uchiyama, F., Hirose, K. and Taneike, T., European Journal Pharmacology, 367, 325 - 334,   1999年, 査読有り
Mechanisms of 5-hydroxytryptamine-induced inhibition in the porcine myometrium., J Autonomic Pharmacol, 19, 65 - 75,   1999年, 査読有り
Involvement of 5-hydroxytryptamine7 receptors in inhibition of porcine myometrial contractility by 5-hydroxytryptamine., Kitazawa T, Kubo O., Satoh M. and Taneike T., British Journal Pharmacology, 123, 172 - 182,   1998年, 査読有り
Functional characterization of neural and smooth muscle motilin receptors in the chicken proventriculus and ileum., Kitazawa T, Taneike T. and Ohga A., Regulatory Peptides, 71, (2) 87 - 95,   1997年, 査読有り

書籍等出版物

Regulation of heart contractility by M2 and M3 muscarinic receptors: functional studies using muscarinic receptor knockout mouse., 共著, Chapter 13, Muscarinic receptor. From Structure to Animal Models. Neuromethods Vol. 107. DOI 10.1007/978-1-4939-2858-3_13@Springer Science+Business Media New York. 2015. 235-259,   2015年08月
動物薬理学, 北澤多喜雄, 分担執筆, 2,3,4,11章, Interzoo,   2014年10月
獣医薬理学, 北澤多喜雄, 分担執筆, 第13章 ホルモン, 近代出版,   2013年03月
薬理学・毒性学実験, 北澤多喜雄, 分担執筆, 25-29P, 117-118P, 文英堂,   2008年04月

講演・口頭発表等

Chicken is a unique animal model for studying function of ghrelin in gastrointestinal motility, 北澤多喜雄, International Symposium on Ghrelin and Energy metabolism Homeostasis,   2017年04月22日
ムスカリン受容体を介した胃粘膜細胞の分化・増殖制御, 松山勇人、内藤清惟、和田善明、永野宏、斉藤正一郎、酒井洋樹、棚橋靖行、北澤多喜雄、小森成一、海野年弘, 第159回日本獣医学会学術集会,   2016年09月07日
Possible regulation of gastrointestinal motility of zebrafish by motilin: An invitro study using isolated muscle strips, 北澤多喜雄, RegPep2016,   2016年07月13日
What is the general action of ghrelin invertebrates? Study focused on gastrointestinal motor stimulating action, 北澤多喜雄, 第93回日本生理学会,   2016年03月24日

作品

脊髄のカテコールアミン反応性, 北澤多喜雄, その他,   1979年04月 - 1981年03月, 北海道大学大学院修士課程での仕事 修士論文の内容は以下に公表した。 Effects of catecholamines on spinal motoneurones and spinal reflex discharges in the isolated spinal cord of the newborn rat. Kitazawa T, Saito K, Ohga A. Brain Res. 1985 Mar;351(1):31-6.

競争的資金

文部科学省, 科学研究費 基盤研究C, グレリン―モチリン系による消化管運動調節機構に関する比較生物学的研究, 北澤多喜雄
文部科学省, 科学研究費 基盤研究C, 成長に伴うグレリン受容体発現及び生理的役割の変化:ニワトリを用いての解析, 北澤多喜雄
文部科学省, 科学研究費 基盤研究B, 腸管の蠕動運動発現メカニズムの究明:各種ノックアウトマウスを武器とした新たな展開, 小森成一
文部科学省, 科学研究費 基盤研究C, ニワトリの成長及び消化管運動におよぼすグレリンの生理的役割に関する研究, 北澤多喜雄
文部科学省, 科学研究費 基盤研究C, ブタ子宮に存在するプロスタノイド受容体とその機能に関する研究, 種池哲朗
文部科学省, 科学研究費 基盤研究C, 発生、成長過程での消化管平滑筋モチリン受容体の変化とその調節因の解明, 北澤多喜雄
文部科学省, 科学研究費 基盤研究C, ブタ子宮筋における5-HT7受容体の機能発現に関する研究, 種池哲朗

教育活動情報

担当経験のある科目

動物形態機能学A, 酪農学園大学
基礎演習1, 酪農学園大学
動物看護関連法規, 酪農学園大学
基礎動物看護学, 酪農学園大学
獣医薬理学実習, 酪農学園大学
動物形態機能学実習, 酪農学園大学
獣医薬理学, 酪農学園大学
動物薬理学, 酪農学園大学


教員総覧