School of Veterinary Medicine, Department of Veterinary Medicine
寺岡宏樹 テラオカ ヒロキ
E-Mail:hteraoka@rakuno.ac.jp
Website:

Last Update :2020/01/10

Researcher Profile and Settings

Name

TERAOKA Hiroki

Affiliation (Master)

School of Veterinary Medicine, Department of Veterinary Medicine

Affiliation & Job

School of Veterinary Medicine Department of Veterinary Medicine
Professor

Degree

(BLANK), Hokkaido University

Research Activities

Research Areas

Environmental science, Environmental dynamic analysis
Environmental science, Environmental impact assessment/Environmental policy
Biological science, Developmental biology
Zootechnical science/Veterinary medical science, Basic veterinary science/Basic zootechnical science
Zootechnical science/Veterinary medical science, Applied veterinary science

Research Interests

Environmental Toxicology,
Developmental Toxicology,
Pharmacology,

Published Papers

Identification of pheasant ghrelin and motilin and their actions on contractility of the isolated gastrointestinal tract., Zhang S, Okuhara Y, Iijima M, Takemi S, 坂田一郎, Kaiya H, Teraoka H, Kitazawa T., General Comparative Endocrinology, 20200100, Refereed
Genetic diversity of cytochrome P450 1A2 with different metabolic activity in domestic cats., Sugiyama S, Uno Y, Amano T, Kitazawa T, Teraoka H., Journal of Veterinary Medical Science, 81, 980, 982, 20190700, Refereed
Genetic diversity of cytochrome P450 2A with different metabolic activity in domestic cats., Sugiyama S, Uno Y, Amano T, Kitazawa T, Teraoka H., Journal of Veterinary Medical Science, 81, 983, 985, 20190700, Refereed
Transcriptional profiling of cytochrome P450 genes in the liver of adult zebrafish, Danio rerio., Kubota A, Kawai YK, Yamashita N, Lee JS, Kondoh D, Zhang S, Nishi Y, Suzuki K, Kitazawa T, Teraoka H., Journal of Toxicological Sciences, 44, 347, 356, 20190500, Refereed
Genetic diversity of cytochrome P450 3A with different metabolic activity in domestic cats., Sugiyama S, Uno Y, Amano T, Kitazawa T, Teraoka H., Journal of Veterinary Medical Science, 81, 598, 600, 20190400, Refereed
Molecular Evolution of Tryptophan Hydroxylases in Vertebrates: A Comparative Genomic Survey., Xu J, Li Y, Lv Y, Bian C, You X, Endoh D, Teraoka H, Shi Q., Genes (Basel), 10, pii: E203.3, 20190300, Refereed
The case for thyroid disruption in early life stage exposures to thiram in zebrafish (Danio rerio)., Chen X, Fang M, Chernick M, Wang F, Yang J, Yu Y, Zheng N, Teraoka H, Nanba S, Hiraga T, Hinton DE, Dong W., Gen Comp Endocrinol., 271, 73, 81, 20190100, Refereed
Αlpha1B-adrenoceptor-mediated positive inotropic and positive chronotropic actions in the mouse atrium., Zhang S, Takahashi R, Yamashita N, Teraoka H, Kitazawa T., Eur J Pharmacol., 839, 82, 88, 20181100, Refereed
Contamination Status of Seven Elements in Hooded Cranes Wintering in South-West Kyushu, Japan: Comparison with Red-Crowned Cranes in Hokkaido, Japan., Teraoka H, Miyagi H, Haraguchi Y, Takase K, Kitazawa T, Noda J., Arch Environ Contam Toxicol., 75, 557, 565, 20181100, Refereed
Limited Expression of Functional Cytochrome P450 2C Subtypes in the Liver and Small Intestine of Domestic Cats., Ono Y, Sugiyama S, Matsushita M, Kitazawa T, Amano T, Uno Y, Ikushiro S, Teraoka H., Xenobiotica, 49, 6, 627, 635, 20190600, Refereed
Comparing time-series of chemical concentrations in zebrafish (Danio rerio) embryos/larvae exposed to teratogens with different hydrophobicity; caffeine, sodium valproate, and diethylstilbestrol., Nawaji T, Mizoguchi N, Ono M, Matuura T, Seki M, Teraoka H., J Toxicol Sci., 43, 4, 267, 273, 20180400, Refereed
Aroclor 1254 and BDE-47 inhibit dopaminergic function manifesting as changes in locomotion behaviors in zebrafish embryos, Tanaka Y, Fujiwara M, Shindo A, Yin G, Kitazawa T abd Teraoka H, Chemosphere, 193, 1207, 1215, 20180200, Refereed
Structural determination, distribution, and physiological actions of ghrelin in the gunea-pig, Okuhara Y, Kaiya H, Teraoka H and Kitazawa T, Peptides, 99, 70, 81, 20180100, Refereed
Protective effect of Ganoderma lucidum polysaccharide against carbon tetrachloride-induced hepatic damage in precision-cut carp liver slices., Liu Y, Zhang C, Du J, Jia R, Cao L, Jeney G, Teraoka H, Xu P, Yin G., Fish Physiol Biochem., 43, 1209, 1221, 20171000, Refereed
Neuropeptide Y (NPY) inhibits spontaneous contraction of the mouse atrium by possible activation of the NPY1 receptor, Oki Y, Teraoka H, Kitazawa T, Autonomic Autacoid Pharmacology, 37, 23, 28, 20170600, Refereed
Dexamethasone-induced hepatomegaly and steatosis in larval zebrafish., Yin G, Cao L, Du J, Jia R, Kitazawa T, Kubota A, Teraoka H., J Toxicol Sci., 42, 455, 459, 20170400, Refereed
Does motilin peptide regulate gastrointestinal motility of zebrafish? An in vitro study using isolated intestinal strips. , Oki Y, Teraoka H, Kitazawa T., Auton Autacoid Pharmacol., 37, 23, 28, 20170300, Refereed
Does motilin peptide regulate gastrointestinal motility of zebrafish? An in vitro study using isolated intestinal strips., Kitazawa T, Yoshida M, Teraoka H, Kaiya H, General and comparative endocrinology, 20170200, Refereed
Characterization of feline cytochrome P450 2B6., Okamatsu G, Komatsu T, Ono Y, Inoue H, Uchide T, Onaga T, Endoh D, Kitazawa T, Hiraga T, Uno Y, Teraoka H, Xenobiotica; the fate of foreign compounds in biological systems, 47, 2, 93, 102, 20170200, Refereed
Functional expression and comparative characterization of four feline P450 cytochromes using fluorescent substrates., Okamatsu G, Kawakami K, Komatsu T, Kitazawa T, Uno Y, Teraoka H, Xenobiotica; the fate of foreign compounds in biological systems, 30, 1, 11, 20161100, Refereed
Protective effect of prostacyclin against pre-cardiac edema caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin and a thromboxane receptor agonist in developing zebrafish., Nijoukubo D, Tanaka Y, Okuno Y, Yin G, Kitazawa T, Peterson RE, Kubota A, Teraoka H, Chemosphere, 156, 111, 117, 20160800, Refereed
Effects of ghrelin and motilin on smooth muscle contractility of the isolated gastrointestinal tract from the bullfrog and Japanese fire belly newt., Kitazawa T, Shimazaki M, Kikuta A, Yaosaka N, Teraoka H, Kaiya H, General and comparative endocrinology, 232, 51, 59, 20160600, Refereed
Accumulation properties of inorganic mercury and organic mercury in the red-crowned crane Grus japonensis in east Hokkaido, Japan., Teraoka H, Okamoto E, Kudo M, Nakayama SM, Ikenaka Y, Ishizuka M, Endo T, Kitazawa T, Hiraga T, Ecotoxicology and environmental safety, 122, 557, 564, 20151200, Refereed
Correlation of ghrelin concentration and ghrelin, ghrelin-O-acetyltransferase (GOAT) and growth hormone secretagogue receptor 1a mRNAs expression in the proventriculus and brain of the growing chicken., Kitazawa T, Hiraga T, Teraoka H, Yaosaka N, Kaiya H, Peptides, 63, 134, 142, 20150100, Refereed
Identification and functional characterization of novel feline cytochrome P450 2A., Okamatsu G, Komatsu T, Kubota A, Onaga T, Uchide T, Endo D, Kirisawa R, Yin G, Inoue H, Kitazawa T, Uno Y, Teraoka H, Xenobiotica; the fate of foreign compounds in biological systems, 45, 6, 503, 510, 20150000, Refereed
[Current understanding of differential sensitivity of animals to toxic substances: species, strain and individual differences]., Teraoka H, Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology, 27, 4, 314, 319, 20141200, Refereed
Involvement of COX2-thromboxane pathway in TCDD-induced precardiac edema in developing zebrafish., Teraoka H, Okuno Y, Nijoukubo D, Yamakoshi A, Peterson RE, Stegeman JJ, Kitazawa T, Hiraga T, Kubota A, Aquatic toxicology (Amsterdam, Netherlands), 154, 19, 26, 20140900, Refereed
Cyp1a reporter zebrafish reveals target tissues for dioxin, Kim KH, Park HJ, Kim JH, Kim S, Williams DR, Kim MK, Jung YD, Teraoka H, Park HC, Choy HE, Shin BA, Choi SY., Aquat Toxicol. 2013 Jun 15;134-135:57-65. , 134-135, 57, 65, 20130600, Refereed
Inhibitory effects of endogenous dopaminergic neurotoxin, norsalsolinol on dopamine secretion in PC12 rat pheochromocytoma cells, Maruyama Y, Teraoka H, Iwata H, Kazusaka A, Fujita S., Neurochem Int., 38, 7, 567, 572, 20010700, Refereed
2,3,7,8-tetrachlorodibenzo-p-dioxin induces apoptosis in the dorsal midbrain of zebrafish embryos by activation of arylhydrocarbon receptor., Neuroscience Letters, 303: 169-172, 169, 172, 20010000
Smooth muscle layer-specific variations in the autonomic innervation of bovine myometrium, Taneike T, Kitazawa T, Funakura H, Asanuma K, Tsuji S, Yamada M, Teraoka H, Ohga A., Gen Pharmacol. , 32, 1, 91, 100, 19990100, Refereed
Fc receptor-mediated phagocytosis, superoxide production and calcium signaling of beta 2 integrin-deficient bovine neutrophils, Nagahata H, Sawada C, Higuchi H, Teraoka H, Yamaguchi M., Microbiol Immunol., 41, 9, 747, 750, 19970900, Refereed
Relationship between the chemiluminescent response of bovine neutrophils and changes in intracellular free calcium concentration, Higuchi H, Nagahata H, Teraoka H, Noda H., Can J Vet Res., 61, 1, 57, 61, 19970100, Refereed
Nicotinic Receptor-mediated Ca2+ Mobilization and Catecholamine Secretion in Chick Adrenal Chromaffin Cells, Hiroki TERAOKA, Rumiko MATSUZAWA, Yutaka MARUYAMA, Takeo HIRAGA and Akira OHGA, Proceedings of the Japan Academy, Ser. B, Physical and Biological Sciences, 72, 3, 52, 55, 19960300, Refereed
Inhibitory effects of caffeine on secretagogue-induced catecholamine secretion from adrenal chromaffin cells of the guinea-pig, Nakazato Y, Tani Y, Teraoka H, Sugawara T, Asano T, Ohta T, Ito S., Br J Pharmacol. 1994 Mar;111(3):935-41., 111, 3, 935, 941, 19940300, Refereed
Difference in the effectiveness of Ca2+ to evoke catecholamine secretion between adrenaline- and noradrenaline-containing cells of bovine adrenal medulla, Teraoka H, Sugawara T, Nakazato Y., J Neurochem. 1993 May;60(5):1936-40., 60, 5, 1936, 1940, 19930500, Refereed
Comparisons of the effects of ryanodine on catecholamine secretion evoked by caffeine and acetylcholine in perfused adrenal glands of the guinea-pig, Nakazato Y, Hayashi H, Teraoka H., Br J Pharmacol. 1992 Mar;105(3):597-602., 105, 3, 597, 602, 19920300, Refereed
Ryanodine inhibits caffeine-evoked Ca2+ mobilization and catecholamine secretion from cultured bovine adrenal chromaffin cells, Teraoka H, Nakazato Y, Ohga A., J Neurochem. 1991 Dec;57(6):1884-90., 57, 6, 1884, 1890, 19911200, Refereed
The role of Na+ in muscarinic receptor-mediated catecholamine secretion in the absence of extracellular Ca2+ in cat perfused adrenal glands, Teraoka H, Yamada Y, Nakazato Y, Ohga A., Br J Pharmacol. 1990 Sep;101(1):67-72., 101, 1, 67, 72, 19900900, Refereed
Sodium ions inhibit the stimulant action of caffeine on catecholamine secretion from adrenal chromaffin cells of the guinea pig, Teraoka H, Nakazato Y, Ohga A., J Neurochem., 108, 1-2, 179, 182, 19900100, Refereed
Intracellular Ca2+ antagonist TMB-8 blocks catecholamine secretion evoked by caffeine and acetylcholine from perfused cat adrenal glands in the absence of extracellular Ca2+, Yamada Y, Teraoka H, Nakazato Y, Ohga A., Neuroscience Letters, 90, 3, 338, 342, 19880800, Refereed
Catecholamines and dopamine-beta-hydroxylase secretion from perfused goat adrenal glands., Yamada Y, Nakazato Y, Ito S, Teraoka H, Ohga A., Q J Exp Physiol. 1988 Jan;73(1):113-21., 73, 1, 113, 121, 19880100, Refereed
Usefulness of zebrafish in evaluating drug-induced teratogenicity in cardiovascular system., Watanabe R, Nakanishi Y, Nijoukubo D, Teraoka H, Ogasawara H, Mori K., Drug Chem Toxicol., in press, Refereed
Inhibitory effects of endogenous dopaminergic neurotoxin, norsal solinol on dopamine secretion in PC12 rat phechromocytoma cells., Neurochemistry International, 38, 567, 572, 20010000
Inositd 1,4,5-trisphosphate-and caffeine-sensitive Ca2+-storing organelle in bovine adrenal chromaffin cells., Hiroki Teraoka, Ryo Takai, Tetsuro Taneike, Takeo Hiraga, Akira Ohga, Japanese Journal of Pharmacology, 72, 4, 307, 315, 19960000
Nicotinic receptor-mediated Ca2+ mobilization and catecholamine secretion in chick adrenal chromaffin cells., Hiroki TERAOKA, Rumiko MATSUZAWA, Yutaka MARUYAMA, Takeo HIRAGA, Akira OHGA, Proceeding of Japan Academy, 72, 3, 52, 55, 19960000
Comparisons of the effects of ryanodine on catecholamine secretion evoked by caffeine and acetylcholine in perfused adrenal glands of guinea pig., British Journal of Pharmacology, 105, 594, 602, 19920000

Books etc

Muscarinic Receptor: From Structure to Animal Models Volume 107 of the series Neuromethods, TERAOKA Hiroki, Contributor, Regulation of heart contractility by M2 and M3 muscarinic receptors,   2015 09
Interdisciplinary Studies on Environmental Chemistry Vol.1 Biological Responses to Chemical Pollutants, TERAOKA Hiroki, Contributor, Prostanoid Signaling Mediates Circulation Failure Caused by TCDD in Developing Zebrafish , TERRAPUB,   2008
Toxicology-Life・Environment・Ecology-,   1999

Conference Activities & Talks

Transcriptional profiling of cytochrome P450 genes in adult liver and in whole embryo fry of zebrafish in some developmental stages, Hiroki Teraoka, Natsumi Yamashita, Yusuke K. Kawai, Shuangyi Zhang, Takio Kitazawa and Akira Kubota, 15th International Congress of Toxicology ,   2019 07 15
1) Developmental neurobehavioral toxicity by non-coplanar PCB and PBDE in zebrafish, 2) Cytochrome P450 in cat : structure, expression, enzymatic activity and polymorphism, TERAOKA Hiroki, 28th LaMer Special Seminar,   2019 05 31 , 招待有り
Mercury contamination in red-crowned crane (Tancho) in Hokkaido: Status, effects and sources, TERAOKA Hiroki, International CHEMICAL HAZARD Symposium in Hokkaido,   2019 03 20 , 招待有り
Αlpha1B-adrenoceptor-mediated positive inotropic and positive chronotropic actions in the mouse atrium, Shuangyi Zhang, Rena Takahashi, Natsumi Yamashita, Hiroki Teraoka, Kitazawa Takio,   2019 03 15
Chicken is a unique animal model for studying function of ghrelin in gastrointestinal motility, Takio Kitazawa, Hiroki Teraoka and Hiroyuki Kaiya, International Symposium on Ghrelin and Energy Metabolism Homeostasis,   2018 04 22
Potentiation of dioxin-induced edema by oxidative stress in developing zebrafish, Katsuki Tanaka, Daisuke Nijoukubo, Hikaru Adachi, Takio Kitazawa, Hiroki Teraoka, Society of Toxicology Annual Meeting 2018,   2018 03 14
Crosstalk between dioxin-induced toxicity and inflammatory response, Tanaka K, Nijoukubo D, Adachi H, Kitazawa T, Teraoka H., ConBio2017,   2017 12 06
Role of melanin synthetic pathway in locomotion behaviour in zebrafish embryos: the involvement in non-coplanar PCB- and PBDE-evoked hyperactivities., Tanaka Y, Fujiwara M, Kitazawa T, Teraoka H., International Symposium on Pollutant Responses in Marine Organisms (PRIMO 19),   2017 07 02
Interaction between thromboxane pathway and oxidative stress in dioxin-induced edema in developing zebrafish., Tanaka K, Nijoukubo D, Kitazawa T, Teraoka H., 19th International Symposium on Pollutant Responses in Marine Organisms (PRIMO 19),   2017 07 02
Chicken is an interesting animal for study of functional role of ghrelin in gastrointestinal tract., Kitazawa T, Teraoka H, Kaiya H., International Symposium on Ghrelin and Energy. Metabolism Homeostasis,   2017 04
Vascular Endothelium Is A Target Of 2,3,7,8-tetrachlorodibenzo-p-dioxin In Cardiac Edema In Early Zebrafish Larvae, Nijoukubo D, Tanaka K, Tanaka Y, Kitazawa T, Teraoka H., SOT2017,   2017 03 16
Evidence for Developmental versus Toxicological Roles for Zebrafish Ahr1b, S. Karchner, M. J. Jenny, N. Aluru, D. G. Franks1, L. B. Laub, E. Linney, L. M. Williams, H. Teraoka, M. E. Hahn, SOT2017,   2017 03 13 , Society of Toxicology
Use of zebrafish, TERAOKA Hiroki, SOT2016,   2016 11 16 , 招待有り
PCB- and PBDE-evoked locomotion behaviors in early developing zebrafish: Involvement of dopaminergic pathway and melanin synthesis, Hiroki Teraoka, Mari Fujiwara, Yasuaki Tanaka, Takio Kitazawa, SOT2016,   2016 10 06
Possible regulation of gastrointestinal motility by motilin in zebrafish -an in vitro study using isolated muscle strips. , Kitazawa T, Teraoka H, Kaiya H., Regulatory Peptide 2016,   2016 07 14
Dexamethasone-induced hepatomegaly and fatty liver in zebrafish, Guojun Yin, Daisuke Nijoukubo, Takio Kitazawaa, Liping Cao, Jinliang Dub, Hiroki Teraoka, SOT2016,   2016 06 30
PROSTACYCLIN INHIBITS PRECARDIAC EDEMA IN DEVELOPING ZEBRAFISH EXPOSED TO 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN, Teraoka H, Nijoukubo D, Yin G, Kitazawa T., SOT2016,   2016 03 16

Awards & Honors

  2007 04 , The Japanese Society of Veterinary Science, Veterinary Science Award

Research Grants & Projects

JSPS, KAKENHI, TERAOKA Hiroki
JSPS, KAKENHI, TERAOKA Hiroki
JSPS, KAKENHI, TERAOKA Hiroki
JSPS, KAKENHI, TERAOKA Hiroki
Development of serotonergic neurons
Developmental Toxicology of Environmental Chemicals
Mechanisms of dioxin-induced Toxicity


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