School of Veterinary Medicine, Department of Veterinary Medicine
岩野英知 イワノ ヒデトモ
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Last Update :2018/09/26

Researcher Profile and Settings

Name

IWANO Hidetomo

Affiliation (Master)

School of Veterinary Medicine, Department of Veterinary Medicine

Affiliation & Job

School of Veterinary Medicine, Department of Veterinary Medicine
lecturer

Education

 - 1999 , Rakuno Gakuen University, Department of Veterinary Research, Doctoral Course Veterinary Medicine
 - 1999 , Rakuno Gakuen University, Department of Dairy Science, Department of Veterinary Medicine

Degree

Doctor (Veterinary Medicine), Rakuno Gakuen University

Association Memberships

Japan Society of Endocrine Disrupter Research
JAPANESE SOCIETY FOR BACTERIOLOGY
JAPAN VETERINARY MEDICAL ASSOCIATION
THE JAPANESE SOCIETY OF TOXICOLOGY
The Japanese Society of Veterinary Science
The Japanese Biochemical Society
The Molecular Biology Society of Japan

Academic & Professional Experience

  2000  - 2002 , Lecturer of COE Research Program,
Institute for Protein Research
  2002  - 2003 , Postdoctoral Fellowships for Research Abroad,
Japan Society for the Promotion of Science

Research Activities

Research Areas

Basic biology, Genetics/Genome dynamics
Biological science, Molecular biology
Zootechnical science/Veterinary medical science, Basic veterinary science/Basic zootechnical science

Research Interests

developmental genetics,
epigenetics,
Developmental Biology,

Published Papers

Identification of a novel mechanism of action of bovine IgG antibodies specific for Staphylococcus aureus., Furukawa M, Yoneyama H, Hata E, Iwano H, Higuchi H, Ando T, Sato M, Hayashi T, Kiku Y, Nagasawa Y, Niimi K, Usami K, Ito K, Watanabe K, Nochi T, Aso H, Veterinary research, 49, 1, 22, 20180200, Refereed
Characterization of the Lytic Capability of a LysK-Like Endolysin, Lys-phiSA012, Derived from a Polyvalent Staphylococcus aureus Bacteriophage., Fujiki J, Nakamura T, Furusawa T, Ohno H, Takahashi H, Kitana J, Usui M, Higuchi H, Tanji Y, Tamura Y, Iwano H, Pharmaceuticals (Basel, Switzerland), 11, 1, 20180200, Refereed
Late pregnancy is vulnerable period for exposure to BPA., Ohtani N, Suda K, Tsuji E, Tanemura K, Yokota H, Inoue H, Iwano H, The Journal of veterinary medical science, 20180100, Refereed
Bacteriophage ΦSA012 Has a Broad Host Range against Staphylococcus aureus and Effective Lytic Capacity in a Mouse Mastitis Model., Iwano H, Inoue Y, Takasago T, Kobayashi H, Furusawa T, Taniguchi K, Fujiki J, Yokota H, Usui M, Tanji Y, Hagiwara K, Higuchi H, Tamura Y, Biology, 7, 1, 20180100, Refereed
Innate immune response of bovine mammary epithelial cells to Mycoplasma bovis., Gondaira S, Higuchi H, Iwano H, Nishi K, Nebu T, Nakajima K, Nagahata H, Journal of veterinary science, 19, 1, 79, 87, 20180100, Refereed
Blood biochemistry and hematological changes in rats after administration of a mixture of three anesthetic agents., Ochiai Y, Baba A, Hiramatsu M, Toyota N, Watanabe T, Yamashita K, Yokota H, Iwano H, The Journal of veterinary medical science, 80, 2, 387, 394, 20171200, Refereed
Adverse effects of maternal exposure to bisphenol F on the anxiety- and depression-like behavior of offspring., Ohtani N, Iwano H, Suda K, Tsuji E, Tanemura K, Inoue H, Yokota H, The Journal of veterinary medical science, 79, 2, 432, 439, 20170200, Refereed
Mycoplasma bovis escapes bovine neutrophil extracellular traps., Gondaira S, Higuchi H, Nishi K, Iwano H, Nagahata H, Veterinary microbiology, 199, 68, 73, 20170200, Refereed
Phage Therapy Is Effective in a Mouse Model of Bacterial Equine Keratitis., Furusawa T, Iwano H, Hiyashimizu Y, Matsubara K, Higuchi H, Nagahata H, Niwa H, Katayama Y, Kinoshita Y, Hagiwara K, Iwasaki T, Tanji Y, Yokota H, Tamura Y, Applied and environmental microbiology, 82, 17, 5332, 5339, 20160900, Refereed
Suppression of liver Apo E secretion leads to HDL/cholesterol immaturity in rats administered ethinylestradiol., Yamaguchi K, Ishii M, Maeda N, Iwano H, Yokota H, FEBS open bio, 6, 9, 928, 936, 20160900, Refereed
Therapeutic potential of endothelin inhibitors in canine hemangiosarcoma., Fukumoto S, Saida K, Sakai H, Ueno H, Iwano H, Uchide T, Life sciences, 159, 55, 60, 20160800, Refereed
Bacteriophage can lyse antibiotic-resistant Pseudomonas aeruginosa isolated from canine diseases., Furusawa T, Iwano H, Higuchi H, Yokota H, Usui M, Iwasaki T, Tamura Y, The Journal of veterinary medical science, 78, 6, 1038, 1038, 20160700, Refereed
Blood biochemical changes in mice after administration of a mixture of three anesthetic agents., Ochiai Y, Iwano H, Sakamoto T, Hirabayashi M, Kaneko E, Watanabe T, Yamashita K, Yokota H, The Journal of veterinary medical science, 78, 6, 956, 956, 20160700, Refereed
Bisphenol A glucuronide/sulfate diconjugate in perfused liver of rats., Inoue H, Kemanai S, Sano C, Kato S, Yokota H, Iwano H, The Journal of veterinary medical science, 78, 5, 737, 737, 20160600, Refereed
Complete Genome Sequences of Broad-Host-Range Pseudomonas aeruginosa Bacteriophages ΦR18 and ΦS12-1., Furusawa T, Iwano H, Higuchi H, Usui M, Maruyama F, Nakagawa I, Yokota H, Tamura Y, Genome announcements, 4, 3, 20160500, Refereed
Weak activity of UDP-glucuronosyltransferase toward Bisphenol analogs in mouse perinatal development., Yabusaki R, Iwano H, Tsushima S, Koike N, Ohtani N, Tanemura K, Inoue H, Yokota H, The Journal of veterinary medical science, 77, 11, 1479, 1484, 20151100, Refereed
Pathological classification of canine mammary tumor based on quantifying mRNA levels of hormonal receptors, SATB1, and Snail in tissue and fine needle biopsy samples., Komatsu T, Iwano H, Ebisawa M, Watabe A, Endo Y, Hirayama K, Taniyama H, Kadosawa T, The Journal of veterinary medical science, 74, 6, 719, 726, 20120600, Refereed
Big endothelin-1 as a tumour marker for canine haemangiosarcoma., Fukumoto S, Miyasho T, Hanazono K, Saida K, Kadosawa T, Iwano H, Uchide T, Veterinary journal (London, England : 1997), 204, 3, 269, 274, 20150600, Refereed
Analysis of trace and major elements in bronchoalveolar lavage fluid of Mycoplasma bronchopneumonia in calves., Suzuki K, Higuchi H, Iwano H, Lakritz J, Sera K, Koiwa M, Taguchi K, Biological trace element research, 145, 2, 166, 171, 20120200, Refereed
Cytokine mRNA profiling and the proliferative response of bovine peripheral blood mononuclear cells to Mycoplasma bovis., Gondaira S, Higuchi H, Iwano H, Nakajima K, Kawai K, Hashiguchi S, Konnai S, Nagahata H, Veterinary immunology and immunopathology, 165, 1-2, 45, 53, 20150500, Refereed
A simplified PCR assay for fast and easy mycoplasma mastitis screening in dairy cattle., Higuchi H, Iwano H, Kawai K, Ohta T, Obayashi T, Hirose K, Ito N, Yokota H, Tamura Y, Nagahata H, Journal of veterinary science, 12, 2, 191, 193, 20110600, Refereed
Epidermal growth factor receptor expression in canine transitional cell carcinoma., Hanazono K, Fukumoto S, Kawamura Y, Endo Y, Kadosawa T, Iwano H, Uchide T, The Journal of veterinary medical science, 77, 1, 1, 6, 20150100, Refereed
Placental transfer of conjugated bisphenol A and subsequent reactivation in the rat fetus., Nishikawa M, Iwano H, Yanagisawa R, Koike N, Inoue H, Yokota H, Environmental health perspectives, 118, 9, 1196, 1203, 20100900, Refereed
Serum big endothelin-1 as a clinical marker for cardiopulmonary and neoplastic diseases in dogs., Fukumoto S, Hanazono K, Miyasho T, Endo Y, Kadosawa T, Iwano H, Uchide T, Life sciences, 118, 2, 329, 332, 20141100, Refereed
Histone H1 null vertebrate cells exhibit altered nucleosome architecture., Hashimoto H, Takami Y, Sonoda E, Iwasaki T, Iwano H, Tachibana M, Takeda S, Nakayama T, Kimura H, Shinkai Y, Nucleic acids research, 38, 11, 3533, 3545, 20100600, Refereed
Effect of dietary eugenol on xenobiotic metabolism and mediation of UDP-glucuronosyltransferase and cytochrome P450 1A1 expression in rat liver., Iwano H, Ujita W, Nishikawa M, Ishii S, Inoue H, Yokota H, International journal of food sciences and nutrition, 65, 2, 241, 244, 20140300, Refereed
Isolation from sewage influent and characterization of novel Staphylococcus aureus bacteriophages with wide host ranges and potent lytic capabilities., Synnott AJ, Kuang Y, Kurimoto M, Yamamichi K, Iwano H, Tanji Y, Applied and environmental microbiology, 75, 13, 4483, 4490, 20090700, Refereed
Antimicrobial susceptibilities of Mycoplasma isolated from bovine mastitis in Japan., Kawai K, Higuchi H, Iwano H, Iwakuma A, Onda K, Sato R, Hayashi T, Nagahata H, Oshida T, Animal science journal = Nihon chikusan Gakkaiho, 85, 1, 96, 99, 20140100, Refereed
Metabolic barrier against bisphenol A in rat uterine endometrium., Matsumoto J, Iwano H, Inoue H, Iwano N, Yamashiki N, Yokota H, Toxicological sciences : an official journal of the Society of Toxicology, 99, 1, 118, 125, 20070900, Refereed
L-type amino acid transporter 1 (LAT1): a new therapeutic target for canine mammary gland tumour., Fukumoto S, Hanazono K, Komatsu T, Ueno H, Kadosawa T, Iwano H, Uchide T, Veterinary journal (London, England : 1997), 198, 1, 164, 169, 20131000, Refereed
Expression of monocarboxylate transporter 1 (MCT1) in the dog intestine., Shimoyama Y, Kirat D, Akihara Y, Kawasako K, Komine M, Hirayama K, Matsuda K, Okamoto M, Iwano H, Kato S, Taniyama H, The Journal of veterinary medical science, 69, 6, 599, 604, 20070600, Refereed
A new treatment for human malignant melanoma targeting L-type amino acid transporter 1 (LAT1): a pilot study in a canine model., Fukumoto S, Hanazono K, Fu DR, Endo Y, Kadosawa T, Iwano H, Uchide T, Biochemical and biophysical research communications, 439, 1, 103, 108, 20130900, Refereed
Monocarboxylate transporter 1 (MCT1) plays a direct role in short-chain fatty acids absorption in caprine rumen., Kirat D, Masuoka J, Hayashi H, Iwano H, Yokota H, Taniyama H, Kato S, The Journal of physiology, 576, 2, 635, 647, 20061000, Refereed
Relationship between concentration of lingual antimicrobial peptide and somatic cell count in milk of dairy cows., Kawai K, Akamatsu H, Obayashi T, Nagahata H, Higuchi H, Iwano H, Oshida T, Yoshimura Y, Isobe N, Veterinary immunology and immunopathology, 153, 3-4, 298, 301, 20130600, Refereed
Down regulation of bisphenol A glucuronidation in carp during the winter pre-breeding season., Daidoji T, Kaino T, Iwano H, Inoue H, Kurihara R, Hashimoto S, Yokota H, Aquatic toxicology (Amsterdam, Netherlands), 77, 4, 386, 392, 20060500, Refereed
L-type amino acid transporter 1 (LAT1) expression in canine mammary gland tumors., Fukumoto S, Hanazono K, Komatsu T, Iwano H, Kadosawa T, Uchide T, The Journal of veterinary medical science, 75, 4, 431, 437, 20130500, Refereed
UDP-glucuronosyltransferase isoforms catalyzing glucuronidation of hydroxy-polychlorinated biphenyls in rat., Daidoji T, Gozu K, Iwano H, Inoue H, Yokota H, Drug metabolism and disposition: the biological fate of chemicals, 33, 10, 1466, 1476, 20051000, Refereed
Bisphenol a glucuronidation and excretion in liver of pregnant and nonpregnant female rats., Inoue H, Tsuruta A, Kudo S, Ishii T, Fukushima Y, Iwano H, Yokota H, Kato S, Drug metabolism and disposition: the biological fate of chemicals, 33, 1, 55, 59, 20050100, Refereed

Books etc

The Japanese Society for Animal Vavvine and Biomedical Research NEWS letter, IWANO Hidetomo,   2012 06

Conference Activities & Talks

Characterization of novel Staphylococcus aureus bacteriophages with wide host ranges and their potential as therapeutic agents for bovine mastitis., Iwano, H., Higuchi, H., Inoue, H., Kobayashi, H., Nagahata, H., Yokota, H., Tanji, Y., Tamura, Y., World buiatrics congress 2012,   2012 06
Bisphenol A was transferred across placenta into the fetus as an inactivated metabolite and subsequently reactivated in hte fetus., IWANO Hidetomo,   2009 12
Bisphenol A was transported across the placenta to fetus as an inactivated metabolite and subsequently reactivated in the fetus., ○M. Nishikawa, H. Iwano, N. Koike, R. Yanagisawa, H. Inoue and H. Yokota,   2009 08
Monocarboxylate transpo-ter 1 (MCT1) in liver of pre-ruminant and adult bovines, IWANO Hidetomo,   2005 09
Expression and Distribution of Monocarboxylate Transporter1 (MCT1) in Gastrointestinal Tract of Calves, IWANO Hidetomo,   2004 04
Expression of methyl-CpG binding proteins in Xenopus early embryos., IWANO Hidetomo,   2001 10
Expression of methyl-CpG binding proteins in Xenopus early embryos., IWANO Hidetomo,   2001 03
Glucuronidation of the environmental estrogens bisphenol A and diethylstilbestrol by an isoform of UDP-glucuronosyltr ansferase, UGT2B1, in the rat liver., IWANO Hidetomo,   1998 10
A Critical Amino Acid Residue, Asp446,forEnzymatic Stability of UDP-glucuronosyltransferase, IWANO Hidetomo,   1998 10

Misc

A critical amino acid residue, Asp446, in UDP-glucuronosyltransferase(共著), Biochemical Journal, 325,   1997
High induction of phenol UDP-glucuronosyltransferase in the kidney medulla of β-naphthoflavone-treated rats., Biochimica Biophysica Acta, 1336,   1997 , 10.1016/S0304-4165(97)00022-6
Inhibitory effects of uridine diphosphate on UDP-glucuronosyltransferase, Life Science, 63, (19) 1693 - 1699,   1998 , 10.1016/S0024-3205(98)00441-X
UDP-glucuronosyltransferase UGTlA7 induced in rat small intestinal mucosa by oral administration of 2-naphthoflavone, European Journal of Biochemistry, 258, (3) 948 - 955,   1998 , 10.1046/j.1432-1327.1998.2580948.x
The significance of aminoacid residue Asp446 for enzymatic stability of rat UDP-glucuronosyltransferase UGTlA6(共著), Archives of Biochemistry and Biophysics, 363,   1999
Glucuronidation of environmental oestrogen bisphenol A by an isoform of UDP-glucuronosyltransferase, UGT2B1, in the rat liver(共著), Biochemical Journal, 340, (2) 405 - 409,   1999 , 10.1042/0264-6021:3400405
Smooth muscle layer-dependent distribution of 5-hydroxy tryptamine 7 receptor in the porcine myometrium, British Journal of Pharmacology, 130, (1) 79 - 89,   2000 , 10.1038/sj.bjp.0703290
cDNA cloning and expression of a bovine phenol UDP-glucuronosyl transferase, Bov UGT1A6., Life Science, (68) 2131 - 2139,   2001 , 10.1016/S0024-3205(01)00992-4
Iwano H, Nakamura M and Tajima S Xenopus MBD3 plays a crucial role in early stage of development, Dev boil., 268 : 416-428,   2004 , 10.1016/j.ydbio.2003.12.032
Inoue, H., Tsuruta, A., Kudo, S., Ishii, T., Fukushima, Y., Iwano, H., Yokota, H., Kato, S.Bisphenol A glucuronidation and excretion in liver of Pregnant and Nonpregnant Female Rats, Drug Metab. Dispos, in press,   2004

Awards & Honors

  1999 , Best Paper Award, Japan Veterinary Council
  1999 , Young Investigator Award, Japan Veterinary Council

Research Grants & Projects

The role of methyl-CpG binding proteins in early development
The role of DNA methylation


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