School of Veterinary Medicine, Department of Veterinary Science
北澤多喜雄 キタザワ タキオ
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Last Update :2018/12/11

Researcher Profile and Settings

Name

KITAZAWA Takio

Affiliation (Master)

School of Veterinary Medicine, Department of Veterinary Science

Education

  1979 04  - 1981 03 , Hokakido University Graduate School
  1975 04  - 1979 03 , Hokkaido University, Veterinary Medicine

Association Memberships

The Japanese Society of Veterinary Nursing
JAPAN SOCIETY OF SMOOTH MUSCLE RESEARCH
THE JAPANESE PHARMACOLOGICAL SOCIETY
THE JAPANESE SOCIETY OF VETERINARY SCIENCE

Academic & Professional Experience

  1992 07  - Today, Rakuno Gakuen University
  2002 10  - 2003 10 , Visiting Professor, Leuven University (Belgium)
  1990 04  - 1992 06 , Kyowa Hakko Co.Ltd
  1981 04  - 1990 03 , Kitasato University

Research Activities

Research Areas

Basic biology, Morphology/Structure
Animal life science, Veterinary medical science, Comparative Animal Pharmacology

Research Interests

musucarinic receptor,
motilin, ghrelin,
Comparative Biology,
Gut hormone,
Autonomic nerve,
Gastrointestinal motility,
Pharmacology ,

Published Papers

Limited expression of functional cytochrome p450 2c subtypes in the liver and small intestine of domestic cats., Ono Y, Sugiyama S, Matsushita M, Kitazawa T, Amano T, Uno Y, Ikushiro S, Teraoka H., Xenobiotica. , doi: 10.1080/00498254.2018.148, 1, 9, 20180600, Refereed
Contamination Status of Seven Elements in Hooded Cranes Wintering in South-West Kyushu, Japan: Comparison with Red-Crowned Cranes in Hokkaido, Japan., Teraoka H, Miyagi H, Haraguchi Y, Takase K, Kitazawa T, Noda J., Arch Environ Contam Toxicol., doi: 10.1007/s00244-018-0541-y, 1, 8, 20180500, Refereed
Post-operative rehabilitation of a dog with tetraparesis resulting from cervical intervertebral disc herniation., Kitazawa Takio, Veterinary Nursing, 22, 2, 35, 40, 20180300, Refereed
Aroclor 1254 and BDE-47 inhibit dopaminergic function manifesting as changes in locomotion behaviors in zebrafish embryos, Tanaka Y, Fujiwara M, Shindo A, Yin G, Kitazawa T abd Teraoka H, Chemosphere, 193, 1207, 1215, 20180100, Refereed
Structural determination, distribution, and physiological actions of ghrelin in the gunea-pig, Okuhara Y, Kaiya H, Teraoka H and Kitazawa T, Peptides, 99, 70, 81, 20180100, Refereed
The chicken is an interesting animal for study of the functional role of ghrelin in the gastrointestinal tract, Kitazawa Takio, Teraoka Hiroki, Kaiya Hiroyuki, Endocrine Journal, 64, S5, S9, 20170700
Neuropeptide Y (NPY) inhibits spontaneous contraction of the mouse atrium by possible activation of the NPY1 receptor, Oki Y, Teraoka H, Kitazawa T, 37, 23, 28, 20170600, Refereed
Does motilin peptide regulate gastrointestinal motility of zebrafish? An in vitro study using isolated intestinal strips., Kitazawa T, Yoshida M, Teraoka H, Kaiya H, General and comparative endocrinology, 249, 15, 23, 20170800, Refereed
Characterization of feline cytochrome P450 2B6., Okamatsu G, Komatsu T, Ono Y, Inoue H, Uchide T, Onaga T, Endoh D, Kitazawa T, Hiraga T, Uno Y, Teraoka H, Xenobiotica; the fate of foreign compounds in biological systems, 47, 2, 93, 102, 20170200, Refereed
Dexamethasone-induced hepatomegaly and steatosis in larval zenrafish, Guojun Yin, Liping Cao, Rui Jia, Kitazawa Takio, Akira Kubota and Hiroki Teraoka, J. Toxicol Sci, 42, 4, 455, 459, 20170000, Refereed
Functional expression and comparative characterization of four feline P450 cytochromes using fluorescent substrates., Okamatsu G, Kawakami K, Komatsu T, Kitazawa T, Uno Y, Teraoka H, Xenobiotica; the fate of foreign compounds in biological systems, 1, 11, 20161100, Refereed
Pharmacological characterization of muscarinic receptor subtypes involved in carbachol-induced contraction of the chicken proventriculus, Kitazawa Takio、Nahoko Kondo, Tetsuro Taneike, SM. J. Gastroenterol. , 2, 1, 1003, 1012, 20161000, Refereed
Protective effect of prostacyclin against pre-cardiac edema caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin and a thromboxane receptor agonist in developing zebrafish., Nijoukubo D, Tanaka Y, Okuno Y, Yin G, Kitazawa T, Peterson RE, Kubota A, Teraoka H, Chemosphere, 156, 111, 117, 20160800, Refereed
Molecular cloning of motilin and mechanism of motilin-induced gastrointestinal motility in Japanese quail., Apu AS, Mondal A, Kitazawa T, Takemi S, Sakai T, Sakata I, General and comparative endocrinology, 233, 53, 62, 20160700, Refereed
Effects of ghrelin and motilin on smooth muscle contractility of the isolated gastrointestinal tract from the bullfrog and Japanese fire belly newt., Kitazawa T, Shimazaki M, Kikuta A, Yaosaka N, Teraoka H, Kaiya H, General and comparative endocrinology, 232, 51, 59, 20160600, Refereed
Accumulation properties of inorganic mercury and organic mercury in the red-crowned crane Grus japonensis in east Hokkaido, Japan., Teraoka H, Okamoto E, Kudo M, Nakayama SM, Ikenaka Y, Ishizuka M, Endo T, Kitazawa T, Hiraga T, Ecotoxicology and environmental safety, 122, 557, 564, 20151200, Refereed
Correlation of ghrelin concentration and ghrelin, ghrelin-O-acetyltransferase (GOAT) and growth hormone secretagogue receptor 1a mRNAs expression in the proventriculus and brain of the growing chicken., Kitazawa T, Hiraga T, Teraoka H, Yaosaka N, Kaiya H, Peptides, 63, 134, 142, 20150100, Refereed
Identification and functional characterization of novel feline cytochrome P450 2A., Okamatsu G, Komatsu T, Kubota A, Onaga T, Uchide T, Endo D, Kirisawa R, Yin G, Inoue H, Kitazawa T, Uno Y, Teraoka H, Xenobiotica; the fate of foreign compounds in biological systems, 45, 6, 503, 510, 20150000, Refereed
Involvement of COX2-thromboxane pathway in TCDD-induced precardiac edema in developing zebrafish., Teraoka H, Okuno Y, Nijoukubo D, Yamakoshi A, Peterson RE, Stegeman JJ, Kitazawa T, Hiraga T, Kubota A, Aquatic toxicology (Amsterdam, Netherlands), 154, 19, 26, 20140900, Refereed
Age-dependent reduction of ghrelin- and motilin-induced contractile activity in the chicken gastrointestinal tract., Kitazawa T, Yoshida A, Tamano T, Teraoka H, Kaiya H, Peptides, 43, 88, 95, 20130500, Refereed
A ganglionic stimulant, 1,1-dimethyl-4-phenylpiperazinium, caused both cholinergic and adrenergic responses in the isolated mouse atrium., Ochi K, Teraoka H, Unno T, Komori S, Yamada M, Kitazawa T, European journal of pharmacology, 704, 1-3, 7, 14, 20130300, Refereed
Large-scale survey of mitochondrial D-loop of the red-crowned crane Grus japonensis in Hokkaido, Japan by convenient genotyping method., Miura Y, Shiomi A, Shiraishi J, Makita K, Asakawa M, Kitazawa T, Hiraga T, Momose Y, Momose K, Masatomi H, Teraoka H, The Journal of veterinary medical science, 75, 1, 43, 47, 20130100, Refereed
Origin of three Red-crowned Cranes Grus japonensis found in northeast Honshu and west Hokkaido, Japan, from 2008 to 2012., Miura Y, Shiraishi J, Shiomi A, Kitazawa T, Hiraga T, Matsumoto F, Teraoka H, Masatomi H, The Journal of veterinary medical science, 75, 9, 1241, 1244, 20130000, Refereed
Evidence for M2 and M3 muscarinic receptor involvement in cholinergic excitatory junction potentials through synergistic activation of cation channels in the longitudinal muscle of mouse ileum., Matsuyama H, Tanahashi Y, Kitazawa T, Yamada M, Komori S, Unno T, Journal of pharmacological sciences, 121, 3, 227, 236, 20130000, Refereed
Ghrelin does not affect gastrointestinal contractility in rainbow trout and goldfish in vitro., Kitazawa T, Itoh K, Yaosaka N, Maruyama K, Matsuda K, Teraoka H, Kaiya H, General and comparative endocrinology, 178, 3, 539, 545, 20120900, Refereed
Changes of mercury contamination in red-crowned cranes, Grus japonensis, in East Hokkaido, Japan., Teraoka H, Tagami Y, Kudo M, Miura Y, Okamoto E, Matsumoto F, Koga K, Uebayashi A, Shimura R, Inoue M, Momose K, Masatomi H, Kitazawa T, Hiraga T, Subramanian A, Archives of environmental contamination and toxicology, 63, 1, 153, 160, 20120700, Refereed
Differential display system with vertebrate-common degenerate oligonucleotide primers: uncovering genes responsive to dioxin in avian embryonic liver., Teraoka H, Ito S, Ikeda H, Kubota A, Abou Elmagd MM, Kitazawa T, Kim EY, Iwata H, Endoh D, Environmental science & technology, 46, 1, 27, 33, 20120100, Refereed
Muscarinic receptor subtypes involved in regulation of colonic motility in mice: functional studies using muscarinic receptor-deficient mice., Kondo T, Nakajima M, Teraoka H, Unno T, Komori S, Yamada M, Kitazawa T, European journal of pharmacology, 670, 1, 236, 243, 20111100, Refereed
Expression of two novel cytochrome P450 3A131 and 3A132 in liver and small intestine of domestic cats., Honda K, Komatsu T, Koyama F, Kubota A, Kawakami K, Asakura H, Uno Y, Kitazawa T, Hiraga T, Teraoka H, The Journal of veterinary medical science, 73, 11, 1489, 1492, 20111100, Refereed
Molecular identification of ghrelin receptor (GHS-R1a) and its functional role in the gastrointestinal tract of the guinea-pig., Kitazawa T, Nakamura T, Saeki A, Teraoka H, Hiraga T, Kaiya H, Peptides, 32, 9, 1876, 1886, 20110900, Refereed
Molecular cloning and expression of cytochrome P450 2D6 in the livers of domestic cats., Komatsu T, Honda K, Kubota A, Kitazawa T, Hiraga T, Teraoka H, The Journal of veterinary medical science, 72, 12, 1633, 1636, 20101200, Refereed
Muscarinic receptor subtypes mediating Ca2+ sensitization of intestinal smooth muscle contraction: studies with receptor knockout mice., Suguro M, Matsuyama H, Tanahashi Y, Unno T, Kitazawa T, Yamada M, Komori S, The Journal of veterinary medical science, 72, 4, 443, 451, 20100400, Refereed
Molecular cloning of growth hormone secretagogue-receptor and effect of quail ghrelin on gastrointestinal motility in Japanese quail., Kitazawa T, Maeda Y, Kaiya H, Regulatory peptides, 158, 1-3, 132, 142, 20091100, Refereed
M3 muscarinic receptors mediate positive inotropic responses in mouse atria: a study with muscarinic receptor knockout mice., Kitazawa T, Asakawa K, Nakamura T, Teraoka H, Unno T, Komori S, Yamada M, Wess J, The Journal of pharmacology and experimental therapeutics, 330, 2, 487, 493, 20090800, Refereed
Excitatory and inhibitory 5-hydroxytryptamine (5-HT) receptors expressed in the isolated porcine uterine muscles., Nakamura T, Kitazawa T, Cao J, Iwamoto T, Teraoka H, Kadota K, Taneike T, European journal of pharmacology, 600, 1-3, 123, 129, 20081200, Refereed
A non-selective cationic channel activated by diacylglycerol in mouse intestinal myocytes., Sakamoto T, Matsuyama H, Yamamoto M, Tanahashi Y, Kitazawa T, Taneike T, Komori S, Unno T, European journal of pharmacology, 599, 1-3, 54, 57, 20081200, Refereed
Characterization of prostanoid receptors present on adrenergic neurons innervating the porcine uterine longitudinal muscle., Cao J, Nakamura T, Kitazawa T, Yamashiki N, Yamamoto T, Taneike T, Prostaglandins & other lipid mediators, 86, 1-4, 26, 34, 20080600, Refereed
Muscarinic receptor subtypes involved in carbachol-induced contraction of mouse uterine smooth muscle., Kitazawa T, Hirama R, Masunaga K, Nakamura T, Asakawa K, Cao J, Teraoka H, Unno T, Komori S, Yamada M, Wess J, Taneike T, Naunyn-Schmiedeberg's archives of pharmacology, 377, 4-6, 503, 513, 20080600, Refereed
Three distinct muscarinic signalling pathways for cationic channel activation in mouse gut smooth muscle cells., Sakamoto T, Unno T, Kitazawa T, Taneike T, Yamada M, Wess J, Nishimura M, Komori S, The Journal of physiology, 582, Pt 1, 41, 61, 20070700, Refereed
Contractile effects of ghrelin-related peptides on the chicken gastrointestinal tract in vitro., Kitazawa T, Kaiya H, Taneike T, Peptides, 28, 3, 617, 624, 20070300, Refereed
Functional roles of muscarinic M2 and M3 receptors in mouse stomach motility: studies with muscarinic receptor knockout mice., Kitazawa T, Hashiba K, Cao J, Unno T, Komori S, Yamada M, Wess J, Taneike T, European journal of pharmacology, 554, 2-3, 212, 222, 20070100, Refereed
Endogenous prostaglandins regulate spontaneous contractile activity of uterine strips isolated from non-pregnant pigs., Cao J, Kitazawa T, Takehana K, Taneike T, Prostaglandins & other lipid mediators, 81, 3-4, 93, 105, 20061200, Refereed
Uterine region-dependent differences in responsiveness to prostaglandins in the non-pregnant porcine myometrium., Cao J, Yosida M, Kitazawa T, Taneike T, Prostaglandins & other lipid mediators, 75, 1-4, 105, 122, 20050100, Refereed
Gastric motor effects of peptide and non-peptide ghrelin agonists in mice in vivo and in vitro., 44. Kitazawa T, De Smet B, Verbeke, K., Depoortere I. and Peeters T., Gut, 54, 8, 1078, 1084, 20050000, Refereed
Intracerebroventricular administration of chicken motilin does not induce hyperphagia in meat-type chicks., Bungo T, Ueda H, Kitazawa T, Taneike T, Furuse M, Physiology & behavior, 82, 2-3, 199, 203, 20040900, Refereed
Thromboxane A2 (TP) receptor in the non-pregnant porcine myometrium and its role in regulation of spontaneous contractile activity., Cao J, Wakatsuki A, Yoshida M, Kitazawa T, Taneike T, European journal of pharmacology, 485, 1-3, 317, 327, 20040200, Refereed
Pregnancy-associated changes in responsiveness of the porcine myometrium to bioactive substances., Kitazawa T, Hatakeyama H, Cao J, Taneike T, European journal of pharmacology, 469, 1-3, 135, 144, 20030500, Refereed
5-HT7 receptor-mediated relaxation of the oviduct in nonpregnant proestrus pigs., Inoue M, Kitazawa T, Cao J, Taneike T, European journal of pharmacology, 461, 2-3, 207, 218, 20030200, Refereed
In vitro pharmacological characterization of the prostanoid receptor population in the non-pregnant porcine myometrium., Cao J, Shayibuzhati M, Tajima T, Kitazawa T, Taneike T, European journal of pharmacology, 442, 1-2, 115, 123, 20020500, Refereed
Muscle layer- and region-dependent distributions of oxytocin receptors in the porcine myometrium., 55. Kitazawa T, Kajiwara T, Kiuchi A, Hatakeyama H. and Taneike T., Peptides, 22, 963, 974, 20010000, Refereed
The mechanisms of α2-adrenoceptor agonist-induced contraction in longitudinal muscle of the porcine uterus., Kitazawa, T., Maezono, Y. and Taneike, T., Eur J Pharmacol, 390, 185, 195, 20000000, Refereed
Characterization of functional endothelin receptors in the porcine myometrium. , Isaka M., Takaoka K., Yamada Y., Abe Y., Kitazawa T. and Taneike T., Peptides, 21, 543, 551, 20000000, Refereed
Change of the involvement of 5-HT3 receptor in the gastric motor stimulating actions of KW-5139 (Leu13-motilin acetate) in the recovered and post-operative periods in dogs., Yokoyama T, Takasaki K, Kitazawa T, Karasawa A and Kusaka H., Life Sciences, 67, 19, 2281, 2292, 20000000, Refereed
Smooth muscle layer-dependent distribution of 5-HT7 receptor in the porcine myometrium., Kitazawa T, Yamada Y, Iwano H, Yokota H, Yuasa A. and Taneike T., Brit. J. Pharmacol, 133, 79, 89, 20000000, Refereed
Smooth musle layer-specific variations in the autonomic innervation of bovine myometrium., Taneike, T., Kitazawa,T., Funakura,H., Asanuma, K., Tsuji, S., Yamada, M., Teraoka, H. and Ohga,, General Pharmacology, 32, 91, 100, 19990000, Refereed
Characterization of the muscarinic receptor subtype that mediates the contractile response of acetylcholine in the swine myometrium., Kitazawa, T., Uchiyama, F., Hirose, K. and Taneike, T., European Journal Pharmacology, 367, 325, 334, 19990000, Refereed
Mechanisms of 5-hydroxytryptamine-induced inhibition in the porcine myometrium., Kitazawa, T., Takaoka, K. and Taneike, T., J Autonomic Pharmacol, 19, 65, 75, 19990000, Refereed
Involvement of 5-hydroxytryptamine7 receptors in inhibition of porcine myometrial contractility by 5-hydroxytryptamine., Kitazawa T, Kubo O., Satoh M. and Taneike T., British Journal Pharmacology, 123, 172, 182, 19980000, Refereed
Functional characterization of neural and smooth muscle motilin receptors in the chicken proventriculus and ileum., Kitazawa T, Taneike T. and Ohga A., Regulatory Peptides, 71, 2, 87, 95, 19970000, Refereed
Alpha1B-adrenoceptor-mediated positive inotropic and positive chronotropic actions in the mouse atrium, Shuangyi Zhang1 Reia Takahashi, Natsumi Yamashita, Hiroki Teraoka and Takio Kitazawa, European J Pharmacology, 839, 82, 88, 20180000, Refereed

Books etc

Regulation of heart contractility by M2 and M3 muscarinic receptors: functional studies using muscarinic receptor knockout mouse., Kitazawa T, Teraoka H, Harada N, Ochi K, Nakamura T, Asakawa K, Kanegae S, Yaosaka N, Unno T, Komori S and Yamada M, Joint Work, Chapter 13, Muscarinic receptor. From Structure to Animal Models. Neuromethods Vol. 107. DOI 10.1007/978-1-4939-2858-3_13@Springer Science+Business Media New York. 2015. 235-259,   2015 08

Conference Activities & Talks

A review of the motilin system in guinea-pig: Re-examination of gastrointestinal motility-stimulating action of guinea-pig motilin candidate in vitro, Kitazawa Takio and Hiroyuki Kaiya, 3rd meeting of the federation of neurogastroenterology and motility,   2018 08 30
Guinea-pig ghrelin, its structure, distribution and function in gastrointestinal trac, Takio Kitazawa, Yuji Okuhara, Hiroyuki Kaiya, Hiroki Teraoka, World Clinical Pharmacology 2018 Kyoto,   2018 07 03
Effects of prostaglandin E2 and F2 α on expression of growth factors and pro-, Shuangyi Zhang, Kitazawa Takio, Jinshan Cao, World Clinical Pharmacology 2018 Kyoto,   2018 07 02
Chicken is a unique animal model for studying function of ghrelin in gastrointestinal motility, Kitazawa Takio, International Symposium on Ghrelin and Energy metabolism Homeostasis,   2017 04 22
Possible regulation of gastrointestinal motility of zebrafish by motilin: An invitro study using isolated muscle strips, Kitazawa Takio, RegPep2016,   2016 07 13
What is the general action of ghrelin invertebrates? Study focused on gastrointestinal motor stimulating action, Kitazawa Takio,   2016 03 24


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