School of Veterinary Medicine, Department of Veterinary Medicine
大杉剛生 オオスギ タケオ
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Last Update :2020/03/30

Researcher Profile and Settings

Name

OHSUGI Takeo

Affiliation (Master)

School of Veterinary Medicine, Department of Veterinary Medicine

Affiliation & Job

Department of Laboratory Animal Sciences, School of Veterinary Medicine
Professor

Education

  1980 04  - 1982 03 , Hokkaido University, School of Veterinary Medicine
 - 1982 , Hokkaido University
  1976 04  - 1980 03 , Rakuno Gakuen University, Faculty of Dairy Science
 - 1980 , Rakuno Gakuen University, Faculty of Veterinary Medicine

Degree

Ph.D.

Academic & Professional Experience

  2014  - Today, Professor, Department of Laboratory Animal Science, School of Veterinary Medicine, Rakuno-Gakuen University
  2001  - 2014 , Associate Professor, Institute of Resource Development and Analysis, Kumamoto University
  1998  - 2000 , Senior Lecturer, School of Medicine, Juntendo University
  1992  - 1997 , Assistant Professor, Department of Virology, School of Medicine, Kurume University
  1988  - 1991 , Research Associate, Medical School, Osaka University
  1986  - 1987 , postdoctoral fellow, Department of Microbiology and Immunology, Lousiana State University medical school in Shreveport

Research Activities

Research Areas

Life sciences, Virology
Life sciences, Molecular biology
Life sciences, Laboratory animal science

Published Papers

High expression of NAMPT in adult T-cell leukemia/lymphoma and anti-tumor activity of a NAMPT inhibitor., Kozako T, Aikawa A, Ohsugi T, Uchida YI, Kato N, Sato K, Ishitsuka K, Yoshimitsu M, Honda SI, European journal of pharmacology, European journal of pharmacology, 865, 172738, 20191200, Refereed
Anti-cancer activity of the cell membrane-permeable phytic acid prodrug., Masunaga T, Murao N, Tateishi H, Koga R, Ohsugi T, Otsuka M, Fujita M, Bioorganic chemistry, Bioorganic chemistry, 92, 103240, 20191100, Refereed
Anesthetic effect of a mixture of alfaxalone, medetomidine, and butorphanol for inducing surgical anesthesia in ICR, BALB/c, and C57BL/6 mouse strains., Tsukamoto Y, Yamada N, Miyoshi K, Yamashita K, Ohsugi T, The Journal of veterinary medical science, The Journal of veterinary medical science, 81, 6, 937, 945, 20190600, Refereed
A novel mouse model of adult T‐cell leukemia cell invasion into the spinal cord, Takeo Ohsugi, Shuhei Tanaka, Keigo Iwasaki, Yusuke Nagano, Tomohiro Kozako, Kazuya Matsuda, Takuya Hirose, Kazushige Takehana, Animal Models and Experimental Medicine, Animal Models and Experimental Medicine, 2, 1, 64, 67, 20190100, Refereed
Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines., Kozako T, Mellini P, Ohsugi T, Aikawa A, Uchida YI, Honda SI, Suzuki T, BMC cancer, BMC cancer, 18, 1, 791, 20180800, Refereed
Development and Molecular Analysis of Synthetic Lethality By Targeting EZH1 and EZH2 in Non-Hodgkin Lymphomas, Blood, Blood, 128, 462, 20161200, Refereed
Expression of DOK1, 2, and 3 genes in HTLV-1-infected T cells, T. Ohsugi, M. Wakamiya, S. Morikawa, M. Fujita, Acta virologica, Acta virologica, 60, 211, 213, 20160600, Refereed
Evaluation of a combination of alfaxalone with medetomidine and butorphanol for inducing surgical anesthesia in laboratory mice., Higuchi S, Yamada R, Hashimoto A, Miyoshi K, Yamashita K, Ohsugi T, The Japanese journal of veterinary research, The Japanese journal of veterinary research, 64, 2, 131, 139, 20160500, Refereed
Stevens-Johnson syndrome/toxic epidermal necrolysis-like disease in human T-cell leukemia virus type 1 Tax transgenic mice, Takeo Ohsugi, Current Trends in Immunology, Current Trends in Immunology, 15, 43, 46, 20140100, Refereed
p53 dysfunction precedes the activation of nuclear factor-κB during disease progression in mice expressing Tax, a human T-cell leukemia virus type 1 oncoprotein., Ohsugi T, Ishida T, Shimasaki T, Okada S, Umezawa K, Carcinogenesis, Carcinogenesis, 34, 9, 2129, 2136, 20130900, Refereed
Viral interference with host mRNA surveillance, the nonsense-mediated mRNA decay (NMD) pathway, through a new function of HTLV-1 Rex: implications for retroviral replication., Nakano K, Ando T, Yamagishi M, Yokoyama K, Ishida T, Ohsugi T, Tanaka Y, Brighty DW, Watanabe T, Microbes and infection, Microbes and infection, 15, 6-7, 491, 505, 20130600, Refereed
Natural infection of murine norovirus in conventional and specific pathogen-free laboratory mice., Ohsugi T, Matsuura K, Kawabe S, Nakamura N, Kumar JM, Wakamiya M, Morikawa S, Urano T, Frontiers in microbiology, Frontiers in microbiology, 4, 12, 20130000, Refereed
A transgenic mouse model of human T cell leukemia virus type 1-associated diseases., Ohsugi T, Frontiers in microbiology, Frontiers in microbiology, 4, 49, 20130000, Refereed
Invasion of histiocytic sarcoma into the spinal cord of HTLV-1 tax transgenic mice with HTLV-1-associated myelopathy/tropical spastic paraparesis-like disease., Ohsugi T, Wakamiya M, Morikawa S, Matsuura K, Kumar JM, Kumasaka T, Yamaguchi K, Oncology research, Oncology research, 20, 9, 403, 410, 20130000, Refereed
Tamoxifen-resistant, ER-positive MAC 51 cell line with a high metastatic potential developed from a spontaneous breast cancer mouse model., Kumar JM, Kombairaju P, Nagarajan P, Subramanian T, Jose J, Ganapathy HS, Ohsugi T, Cell and tissue research, Cell and tissue research, 350, 2, 347, 360, 20121100, Refereed
Low CD4/CD8 T-cell ratio associated with inflammatory arthropathy in human T-cell leukemia virus type I Tax transgenic mice., Ohsugi T, Kumasaka T, PloS one, PloS one, 6, 4, e18518, 20110400, Refereed
Increased production of viral proteins by a 3'-LTR-deleted infectious clone of human T-cell leukemia virus type 1., Ohsugi T, Virology journal, Virology journal, 6, 229, 20091200, Refereed
Biscoclaurine alkaloid cepharanthine inhibits the growth of primary effusion lymphoma in vitro and in vivo and induces apoptosis via suppression of the NF-kappaB pathway., Takahashi-Makise N, Suzu S, Hiyoshi M, Ohsugi T, Katano H, Umezawa K, Okada S, International journal of cancer, International journal of cancer, 125, 6, 1464, 1472, 20090900, Refereed
A novel mouse model of adult T-cell leukemia cell invasion into the spinal cord, Ohsugi T, Tanaka S, Iwasaki K, Nagano Y, Kozako T, Matsuda K, Hirose T, Takehana K, Animal Model Exp Me, Animal Model Exp Me, 2, 1, 67, 69, 20090100, Refereed
The Tax protein of HTLV-1 promotes oncogenesis in not only immature T cells but also mature T cells., Ohsugi T, Kumasaka T, Okada S, Urano T, Nature medicine, Nature medicine, 13, 5, 527, 528, 20070500, Refereed

Books etc

Encyclopedia of Virology Research, Ohsugi,T, Koito, A, 分担執筆, Human T-cell Leukemia Virus Type 1 (HTLV-1) and Antiviral Enzyme APOBEC3, NOVA Scientific publishers,   2012
JSPS RONPAKU (Dissertation Ph.D.) program abstracts of dissertation for FY 2009, OHSUGI Takeo, 分担執筆, Molecular analysis of estrogen dependent breast cancer in animal model and cell lines.,   2011

Conference Activities & Talks

Development and molecular analysis of synthetic lethality by targeting EZH1/2 in ATL and HTLV-1-infected cells, Yamagishi, M, Hori, M, Fujiwara, D, Honma, D, Adachi, N, Ohsugi, T, Nakano, K, Nakashima, M, Kobayashi, S, Iwanaga, M, Utsunomiya, A, Tanaka, Y, Okada, S, Tsukasaki, K, Toninai, K, Araki, K, Watanabe, T, Uchimaru, K, 18th International Conference on Human Retrovirology HTLV and Related Viruses,   2017 03 07
Tamoxifen inhibits the infiltration of human T-cell leukemia virus type 1-infected cells into organs in a mouse model of adult T-cell leukemia., Tanaka, Y, Kozuka, T, Yamagishi, M, Hirose, T, Nagano, Y, Nishii, R, Kitamura, H, Takehana, K, Watanabe, T, Ohsugi, T, 18th International Conference on Human Retrovirology HTLV and Related Viruses,   2017 03 07
Development and Molecular Analysis of Synthetic Lethality By Targeting EZH1 and EZH2 in Non-Hodgkin Lymphomas, Makoto Yamagishi, Makoto Hori, Dai Fujikawa, Daisuke Honma, Nobuaki Adachi, Takeo Ohsugi, Kazumi Nakano, Makoto Nakashima, Seiichiro Kobayashi, Masako Iwanaga, Atae Utsunomiya, Seiji Okada, Kunihiro Tsukasaki, Kensei Tobinai, Kazushi Araki, Toshiki Watanabe, Kaoru Uchimaru, ASH 58th annual meeting & exposition,   2016 12 04


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